Solid‐in‐oil nanodispersions for transdermal drug delivery systems

Abstract

Transdermal administration of drugs has advantages over conventional oral administration or administration using injection equipment. The route of administration reduces the opportunity for drug evacuation before systemic circulation, and enables long‐lasting drug administration at a modest body concentration. In addition, the skin is an attractive route for vaccination, because there are many immune cells in the skin. Recently, solid‐in‐oil nanodisperison (S/O) technique has demonstrated to deliver cosmetic and pharmaceutical bioactives efficiently through the skin. S/O nanodispersions are nanosized drug carriers designed to overcome the skin barrier. This review discusses the rationale for preparation of efficient and stable S/O nanodispersions, as well as application examples in cosmetic and pharmaceutical materials including vaccines. Drug administration using a patch is user‐friendly, and may improve patient compliance. The technique is a potent transcutaneous immunization method without needles.

Solid-in-Oil Nanodispersions for Transcutaneous Immunotherapy of Japanese Cedar Pollinosis

“…S/O nanodispersions are oil-based nano-sized dispersions of an antigen formed by coating antigen molecules with hydrophobic surfactant molecules. The antigen-surfactant complex is derived from a water-in-oil (W/O) emulsion by lyophilization to remove the water and organic solvent followed by dispersion in an oil vehicle ( Figure 2) [60]. Compared with a W/O emulsion, S/O nanodispersions exhibit higher antigen-encapsulation efficiency up to 99.5% and better stability of more than 6 months [60,61].…”

“…The antigen-surfactant complex is derived from a water-in-oil (W/O) emulsion by lyophilization to remove the water and organic solvent followed by dispersion in an oil vehicle ( Figure 2) [60]. Compared with a W/O emulsion, S/O nanodispersions exhibit higher antigen-encapsulation efficiency up to 99.5% and better stability of more than 6 months [60,61]. Owing to the hydrophobic surfactant and the oil vehicle, S/O nanodispersions can overcome the barrier of the stratum corneum to deliver antigens into the skin.…”

“…Preparation and application of S/O nanodispersions. Reproduced from[60], which is licensed under a Creative Commons Attribution-(CC BY 4.0) International License.…”

A new strategy for the passive skin delivery of nanoparticulate, high molecular weight hyaluronic acid prepared by a polyion complex method

“…It has been reported the HA can be delivered into the skin by micro-needles and iontophoresis. Recently, the solid-in-oil (S/O) technique has been used to deliver high molecular weight compounds into the skin 11 . S/O nanodispersions are nanosized drug carriers designed to overcome the skin barrier.…”

Editorial: Asian Congress of Biotechnology 2015

“…The review by Prof. Masahiro Goto et al on solid‐in‐oil nanodispersions for transdermal drug delivery systems discusses the rationale for preparation of efficient and stable nanosized drug carriers with some application examples in delivery of cosmetic and pharmaceutical bioactives including vaccines. Transdermal administration of drugs has many advantages over conventional oral administration or administration using injection equipment.…”