Transdermal Drug Delivery: Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing (Adv. Healthcare Mater. 12/2021)

Yao, Shun; Chi, Junjie; Wang, Yuetong; Zhao, Yuanjin; Luo, Yuan; Wang, Yongan

doi:10.1002/adhm.202170056

Cited by 31 publications

(50 citation statements)

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“…The mechanical strength of the MNs was measured to be 0.9 N per needle when the displacement was 0.2 mm. Compared with previous reports, 35 the MNs had sufficient mechanical strength. To explore the penetration depth of the tips, MNs were puncturing into isolated rat skin.…”

Section: Mechanical Strength and Insertion Capability Of The Mnscontrasting

confidence: 59%

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Dissolving microneedles with a biphasic release of antibacterial agent and growth factor to promote wound healing

et al. 2022

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Section: Mechanical Strength and Insertion Capability Of The Mnscontrasting

confidence: 59%

“…[24][25][26][27][28][29][30][31] Since the contact area between the MNs and the wound is greatly increased, MNs loaded with active drugs have also been used to promote wound healing and have a significant therapeutic effect. [32][33][34][35] Based on these merits, MNs are considered a robust drug delivery system for wound healing.…”

Section: Introductionmentioning

confidence: 99%

Dissolving microneedles with a biphasic release of antibacterial agent and growth factor to promote wound healing

et al. 2022

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“…[ 37 ] The metal ions and the rough surface of these crystals, which can increase the contact area between MOFs and tissues, have been considered to enhance the biological effect of MOFs. [ 38 ] On the basis of the previous research, zinc and copper ions were the regenerative factors for the tendon‐to‐bone interface repair . [ 39 ] In this study, due to exceptional thermal and chemical resistance to water and organic solvents, the ZIF‐11 was selected as the regenerative factor rather than other ZIFs, which should be mixed in the organic solvent (hexafluoroisopropanol) during the electrospun fabrication.…”

Section: Resultsmentioning

confidence: 99%

Bipolar Metal Flexible Electrospun Fibrous Membrane Based on Metal–Organic Framework for Gradient Healing of Tendon‐to‐Bone Interface Regeneration

Yang

Zheng

Yin

et al. 2022

Adv Healthcare Materials

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Metal ions play a significant role in tissue repair, with widely application in clinical treatment. However, the therapeutic effect of metal ions is always limited due to metabolization and narrow repair capability. Here, a bipolar metal flexible electrospun fibrous membrane based on a metal–organic framework (MOF), which is bioinspired by the gradient structure of the tendon‐to‐bone interface, with a combination of regulating osteoblasts differentiation and angiogenesis properties, is constructed successfully by a continuous electrospinning technique and matching the longitudinal space morphology for synchronous regeneration. Furthermore, the MOF, acting as carriers, can not only achieve the sustainable release of metal ions, but promote the osteogenesis and tenogenesis on the scaffold. The in vitro data show that this novel hierarchical structure can accelerate the tenogenesis, the biomineralization, and angiogenesis. Moreover, in the in vivo experiment, the flexible fibrous membrane can promote tendon and bone tissue repair, and fibrocartilage reconstruction, to realize the multiple tissue synchronous regeneration at the damaged tendon‐to‐bone interface. Altogether, this newly developed bipolar metal flexible electrospun fibrous membrane based on a MOF, as a new biomimetic flexible scaffold, has great potential in reconstruct the tissue damage, especially gradient tissue damage.

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“…However, the toxin concentration detected by the NIH‐3T3 cytotoxicity assay is within 72 h, making it difficult to extrapolate the results to scenarios, where other, less‐sensitive tests are used. [ 29 ] Another previous study demonstrated that ZIF‐8 shows no significant cytotoxicity in various cell lines up to a threshold value of 30 µg mL −1 , showing cytotoxicity at higher concentrations. [ 30 ] Regarding the mechanism, cytotoxicity results from the effects of released Zn 2+ on mitochondrial production of reactive oxygen species and may cause irreversible DNA damage, ultimately initiating cellular apoptosis pathways.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Bone Regeneration Using a ZIF‐8‐Loaded Fibrin Composite Scaffold

Shi

Bian

et al. 2022

Macromolecular Bioscience

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In the present study, fibrin‐based biomaterials made of zeolite imidazole framework‐8 (ZIF‐8) and fibrin gel (Z‐FG) are fabricated with the aim of enhancing skull regeneration. X‐ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet (UV)–vis spectrophotometry, Fourier transform infrared spectroscopy, and rheometry are used to characterize ZIF‐8 and Z‐FG. The influences of ZIF‐8 on the physical properties of fibrin gel (e.g., porosity, modulus, and in vitro biodegradation) are investigated, and the effect of ZIF‐8 concentration on fibrin gel properties in vitro is determined by seeding ectomesenchymal stem cells (EMSCs) over Z‐FG. EMSC osteogenic differentiation reveals higher expression of bone‐related proteins and higher calcium deposition and alkaline phosphatase activity, indicating that Z‐FG may be a good osteoinductive biomaterial. Furthermore, these results show that the piezochannel and yes‐associated protein (YAP) signaling pathway are involved in the differentiation process. In addition, the in vivo results demonstrate that Z‐FG increases bone formation in critical‐sized calvarial defects in rats. Thus, the developed composite scaffold may be a suitable biomaterial for skull tissue‐engineering applications.

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Transdermal Drug Delivery: Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing (Adv. Healthcare Mater. 12/2021)

Cited by 31 publications

References 0 publications

Dissolving microneedles with a biphasic release of antibacterial agent and growth factor to promote wound healing

Dissolving microneedles with a biphasic release of antibacterial agent and growth factor to promote wound healing

Bipolar Metal Flexible Electrospun Fibrous Membrane Based on Metal–Organic Framework for Gradient Healing of Tendon‐to‐Bone Interface Regeneration

Enhanced Bone Regeneration Using a ZIF‐8‐Loaded Fibrin Composite Scaffold

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