Infected wound healing is a complex and dynamic process, which affects millions of people. Since wound healing contains multiple stages, it requires staged managements to realize early inhibit infection and...
This
work describes the synthesis, structure, and physical and
thermomechanical properties of fully biobased unsaturated copolyesters
via melt-polycondensation of renewable monomers trans-β-hydromuconic acid and fumaric acid with 1,4-butanediol conducted
by a two-step polymerization employing stannous octoate as a catalyst
and 4-methoxyphenol as a radical inhibitor. The polymerization conditions,
including catalyst amount, second-stage reaction temperature, and
time, were optimized to prepare high molecular mass unsaturated copolyesters
without isomerization and saturation reaction in the unsaturated double
bonds. Consequently, a series of poly(butylene hydromuconoate-co-butylene fumarate) (PBHBF) samples with weight-average
molecular weight over 80 kg/mol were obtained. The chemical structures
identified by 1H and 13C NMR indicated that
the notorious side reactions of isomerization and saturation of CC
bonds in unsaturated polyesters were eliminated in the obtained PBHBF
copolyesters. From the physical property analyses by wide-angle X-ray
diffraction (WAXD), polarized optical microscopy (POM), and differential
scanning calorimetry (DSC), semicrystalline nature was evidenced for
all the samples; furthermore, isodimorphic behavior was observed in
this copolyester system. The crystallinity degree and thermal properties
including glass transition, melting, and crystallization temperatures
could be effectively adjusted by controlling the comonomer composition.
The resulting copolyesters exhibited excellent tensile properties,
which were comparable or even superior to those of polyethylene and
most well-known saturated aliphatic polyesters. Overall, these biobased
unsaturated polyesters with superior thermomechanical properties and
potential biodegradation appear to be the promising materials for
practical applications.
Carbon monoxide (CO) is regarded as a promising therapeutic agent for chemotherapy sensitization. To simultaneously achieve controllable in-situ CO production and efficient chemotherapeutics delivery is of great significance. Here, a...
Melanoma is the most aggressive skin malignancy that continues to increase in worldwide. The transferability and multidrug resistance lead to high fatality rate. Synergistic administration of hydrophilic carboplatin (CBP) and...
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