Transcutaneous systemic photobiomodulation reduced lung inflammation in experimental model of asthma by altering the mast cell degranulation and interleukin 10 level

Alonso, Paula Tatiane; Schapochnik, Adriana; Klein, Simone; Brochetti, Robson Alexandre; Damazo, Amílcar Sabino; Destro, Maria Fernanda de Souza Setúbal; Lino-dos-Santos-Franco, Adriana

doi:10.1007/s10103-021-03359-1

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…Other animal study using the same parameters mentioned above evaluated the effects of VPBM treatment in an animal model of asthma [ 17 ]. The authors again showed the beneficial effects of VPBM, with reduced cell migration into the lungs, and less mast cell degranulation.…”

Section: Resultsmentioning

confidence: 99%

“…Considering that asthma symptoms are dependent on mast cell degranulation, which causes lung inflammation, we suggest that VPBM could be useful in asthma treatment. Moreover, VPBM increased the levels of interleukin 10 (IL-10) [ 17 ] suggesting that inflammation was reduced since this cytokine has an anti-inflammatory function. However, it is important to mention that the tracheal hyperresponsiveness was not reversed by the VPBM treatment, and this symptom is very troublesome in asthmatic patients, frequently necessitating emergency room visits.…”

Section: Resultsmentioning

confidence: 99%

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Intravascular laser irradiation of blood (ILIB) used to treat lung diseases: a short critical review

et al. 2023

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Intravascular laser irradiation of blood (ILIB) was developed to treat cardiovascular diseases due to its rheological effects. In its original form, ILIB was applied by an intravenous optical fiber, restricting its application. However, this technique was modified to non-invasive irradiation through the radial artery, now called vascular photobiomodulation (VPBM). Many studies have used both, ILIB and VPBM, to treat lung diseases. It is well established that lung diseases affect more than 300 million people worldwide with high morbidity and mortality rates. In this short critical review, we discuss the potential benefits of photobiomodulation to treat lung diseases using these two approaches. The search was performed in the electronic database of MEDLINE (Medical Literature Analysis and Retrieval System Online) via PubMed. The data search was carried out from 1991 to 2017. We selected a total of 10 clinical studies using either ILIB or VPBM, in addition to 2 experimental studies in animals. The respiratory diseases treated in these studies included bronchitis, asthma, pneumonia, and tuberculosis. The results showed overall beneficial effects on lung diseases, characterized by a reduction in the inflammatory cascade and antioxidant effects, improvement of hemodynamic parameters, the efficiency of gas exchange, and reduction of hospitalization periods. In conclusion, all studies showed promising effects of ILIB in both animal and human studies. The studies did not discuss any disadvantages or contraindications. However, further studies are needed in order to understand the dosimetry, and the literature is lacking in randomized, controlled clinical trials. Thus, this review highlights the need for additional studies using this approach.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Intravascular laser irradiation of blood (ILIB) used to treat lung diseases: a short critical review

et al. 2023

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“…After analyzing these results, we propose that photobiomodulation holds the potential to reduce disease severity by upregulating IL-10 release. Several studies indicate a potential mechanism for the modulatory effects of PBM in the lungs through the release of IL-10 ( 34 – 36 ). Therefore, we urge other research groups to delve into the potential of laser therapy, given its promising outcomes in COPD.…”

Section: Discussionmentioning

confidence: 99%

Effect of photobiomodulation in the balance between effector and regulatory T cells in an experimental model of COPD

Brito,

Herculano,

de Alvarenga-Nascimento

et al. 2024

Front. Med.

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IntroductionCurrently, Chronic Obstructive Pulmonary Disease (COPD) has a high impact on morbidity and mortality worldwide. The increase of CD4+, CD8+ cells expressing NF-κB, STAT4, IFN-γ and perforin are related to smoking habit, smoking history, airflow rate, obstruction and pulmonary emphysema. Furthermore, a deficiency in CD4+CD25+Foxp3+ regulatory T cells (Tregs) may impair the normal function of the immune system and lead to respiratory immune disease. On the other hand, the anti-inflammatory cytokine IL-10, produced by Treg cells and macrophages, inhibits the synthesis of several pro-inflammatory cytokines that are expressed in COPD. Therefore, immunotherapeutic strategies, such as Photobiomodulation (PBM), aim to regulate the levels of cytokines, chemokines and transcription factors in COPD. Consequently, the objective of this study was to evaluate CD4+STAT4 and CD4+CD25+Foxp3+ cells as well as the production of CD4+IFN- γ and CD4+CD25+IL-10 in the lung after PBM therapy in a COPD mice model.MethodsWe induced COPD in C57BL/6 mice through an orotracheal application of cigarette smoke extract. PMB treatment was applied for the entire 7 weeks and Bronchoalveolar lavage (BAL) and lungs were collected to study production of IFN- γ and IL-10 in the lung. After the last administration with cigarette smoke extract (end of 7 weeks), 24 h later, the animals were euthanized. One-way ANOVA followed by NewmanKeuls test were used for statistical analysis with significance levels adjusted to 5% (p < 0.05).ResultsThis result showed that PBM improves COPD symptomatology, reducing the number of inflammatory cells (macrophages, neutrophils and lymphocytes), the levels of IFN-γ among others, and increased IL-10. We also observed a decrease of collagen, mucus, bronchoconstriction index, alveolar enlargement, CD4+, CD8+, CD4+STAT4+, and CD4+IFN-γ+ cells. In addition, in the treated group, we found an increase in CD4+CD25+Foxp3+ and CD4+IL-10+ T cells.ConclusionThis study suggests that PBM treatment could be applied as an immunotherapeutic strategy for COPD.

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“…Most applications of PBM focus on the local effects on tissue that is directly exposed to far-red or NIR light. However, indirect systemic effects of PBM on wound-healing, lung inflammation, and Parkinson's disease have been demonstrated [18,[26][27][28]. The deeper skin penetration of NIR compared to other visible light (red or blue) might contribute to the broader beneficial responses [29].…”

Section: Introductionmentioning

confidence: 99%

Effects of Near-Infrared Light on Well-Being and Health in Human Subjects with Mild Sleep-Related Complaints: A Double-Blind, Randomized, Placebo-Controlled Study

Giménez

Luxwolda

Stipriaan

et al. 2022

Biology

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Modern urban human activities are largely restricted to the indoors, deprived of direct sunlight containing visible and near-infrared (NIR) wavelengths at high irradiance levels. Therapeutic exposure to doses of red and NIR, known as photobiomodulation (PBM), has been effective for a broad range of conditions. In a double-blind, randomized, placebo-controlled study, we aimed to assess the effects of a PBM home set-up on various aspects of well-being, health, sleep, and circadian rhythms in healthy human subjects with mild sleep complaints. The effects of three NIR light (850 nm) doses (1, 4, or 6.5 J·cm−2) were examined against the placebo. Exposure was presented five days per week between 9:30 am and 12:30 pm for four consecutive weeks. The study was conducted in both summer and winter to include seasonal variation. The results showed PBM treatment only at 6.5 J·cm−2 to have consistent positive benefits on well-being and health, specifically improving mood, reducing drowsiness, reducing IFN-γ, and resting heart rate. This was only observed in winter. No significant effects on sleep or circadian rhythms were noted. This study provides further evidence that adequate exposure to NIR, especially during low sunlight conditions, such as in the winter, can be beneficial for human health and wellness.

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Transcutaneous systemic photobiomodulation reduced lung inflammation in experimental model of asthma by altering the mast cell degranulation and interleukin 10 level

Cited by 10 publications

References 32 publications

Intravascular laser irradiation of blood (ILIB) used to treat lung diseases: a short critical review

Intravascular laser irradiation of blood (ILIB) used to treat lung diseases: a short critical review

Effect of photobiomodulation in the balance between effector and regulatory T cells in an experimental model of COPD

Effects of Near-Infrared Light on Well-Being and Health in Human Subjects with Mild Sleep-Related Complaints: A Double-Blind, Randomized, Placebo-Controlled Study

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