Transcription analysis of genes involved in lipid metabolism reveals the role of chromium in reducing body fat in animal models

Sadeghi, Mostafa; Panah, Mohammad Javad Najaf; Bakhtiarizadeh, Mohammad Reza; Emami, Ali

doi:10.1016/j.jtemb.2015.05.004

Cited by 20 publications

(11 citation statements)

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“…Supplementing goats with Cr decreased the expression level of ACACA, FASN , and FABP4 (Sadeghi et al, 2015) as measured by RT-PCR. Furthermore, increased Longissimus muscle area and reduced fat thickness was associated with a downregulation of ACACA expression in Cr-supplemented goats (Najafpanah et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, increased Longissimus muscle area and reduced fat thickness was associated with a downregulation of ACACA expression in Cr-supplemented goats (Najafpanah et al, 2014). It seems to follow that Cr supplementation can improve meat quality by altering the direction of energy accumulation from fat deposition toward muscle growth in goats (Najafpanah et al, 2014; Sadeghi et al, 2015). Cr-supplemented Angus-cross steers were also found with increased Longissimus muscle area and decreased IMF without affecting growth performance (Kneeskern et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle

et al. 2019

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Meat quality is a complex trait that is influenced by genetic and environmental factors, which includes mineral concentration. However, the association between mineral concentration and meat quality, and the specific molecular pathways underlying this association, are not well explored. We therefore analyzed gene expression as measured with RNA-seq in Longissimus thoracis muscle of 194 Nelore steers for association with three meat quality traits (intramuscular fat, meat pH, and tenderness) and the concentration of 13 minerals (Ca, Cr, Co, Cu, Fe, K, Mg, Mn, Na, P, S, Se, and Zn). We identified seven sets of co-expressed genes (modules) associated with at least two traits, which indicates that common pathways influence these traits. From pathway analysis of module hub genes, we further found an over-representation for energy and protein metabolism (AMPK and mTOR signaling pathways) in addition to muscle growth, and protein turnover pathways. Among the identified hub genes FASN, ELOV5, and PDE3B are involved with lipid metabolism and were affected by previously identified eQTLs associated to fat deposition. The reported hub genes and over-represented pathways provide evidence of interplay among gene expression, mineral concentration, and meat quality traits. Future studies investigating the effect of different levels of mineral supplementation in the gene expression and meat quality traits could help us to elucidate the regulatory mechanism by which the genes/pathways are affected.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle

et al. 2019

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Section: Introductionmentioning

confidence: 99%

“…Previous studies indicated that organic Cr is absorbed more efficiently [ 12 ], and has a higher bioavailability than inorganic Cr [ 13 ]. Different organic forms of Cr would be expected to have different bioavailabilities [ 12 , 14 ]. Published studies describing the effects of organic Cr on broilers, including increasing immune response and alleviating the negative effects of heat stress [ 15 , 16 ], increasing the weight of pectoral muscles [ 17 ], decreasing body fat deposition in broilers [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers

Chen

Gao

Chu

et al. 2018

Asian-Australas J Anim Sci

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ObjectiveThis experiment was conducted to investigate the effects of chromium picolinate (CrP) on fat deposition, genetic expression and enzymatic activity of lipid metabolism-related enzymes.MethodsTwo hundred forty one-day-old Ross broilers were randomly divided into 5 groups with 4 replicates per group and 12 Ross broiler chicks per replicate. The normal control group was fed a basal diet, and the other groups fed the same basal diet supplemented with 0.1, 0.2, 0.4, and 0.8 mg/kg CrP respectively. The experiment lasted for 21 days.ResultsAdded CrP in the basal diet decreased the abdominal fat, had no effects on subcutaneous fat thickness and inter-muscular fat width; 0.2 mg/kg CrP significantly decreased the fatty acid synthase (FAS) enzymatic (p<0.05); acetyl-CoA carboxylase (ACC) enzymatic activity decreased in all CrP groups (p<0.05); hormone-sensitive lipase (HSL) enzymatic activity also decreased, but the change was not significant (p>0.05); 0.4 mg/kg CrP group significantly decreased the lipoprotein lipase (LPL) enzymatic activity. FAS mRNA expression increased in all experimental groups, and the LPL mRNA expression significantly increased in all experimental groups (p<0.05), but not 0.2 mg/kg CrP group.ConclusionThe results indicated that adding CrP in basal diet decreased the abdominal fat percentage, had no effects on subcutaneous fat thickness and inter-muscular fat width, decreased the enzymatic activity of FAS, ACC, LPL and HSL and increased the genetic expression levels of FAS and LPL.

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“…Considering that the effect of chromium on the fat reduction of the animal carcass is related, among other factors, to the activity of enzymes that synthesize fatty acids (Wang et al 2014, Sadeghi et al 2015, it is expected that their supply will affect the lipid profile of the fat depots.…”

Section: Introductionmentioning

confidence: 99%

Effect of chromium yeast supplementation on lipid profile of swine fat

Alencar

Kiefer

Nascimento

et al. 2021

An. Acad. Bras. Ciênc.

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This study was conducted to evaluate the period of chromium yeast supplementation on lipid profi le of backfat and Longissimus lumborum muscle of barrows. It was evaluated carcass samples from forty barrows, genetically similar. Pigs diets were supplemented with 0.4 mg kg -1 of chromium yeast in four periods (0, 38, 62 and 94 days before slaughter). The experimental design was completely randomized with four treatments, ten replicates, and each experimental unit consisting of one animal. Lipid profi les of backfat and Longissimus lumborum muscle were analyzed by gas chromatography. The increase in the period of chromium yeast use had a quadratic effect (P<0.05) for stearic and oleic fatty acids, and total saturated, monounsaturated and unsaturated fatty acids in backfat. DH-γ-linolenic and arachidonic fatty acids reduced when the period of chromium yeast use increased. In the meat, there was a quadratic effect (P<0.05) only in the γ-linoleic fatty acid. The use of chromium yeast for different periods infl uences the lipid profi le of the backfat and the Longissimus lumborum muscle, with less effect in the meat.

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Transcription analysis of genes involved in lipid metabolism reveals the role of chromium in reducing body fat in animal models

Cited by 20 publications

References 50 publications

Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle

Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle

Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers

Effect of chromium yeast supplementation on lipid profile of swine fat

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