Transcatheter intracavitary fibrinolysis of loculated pleural effusions: Experience in 102 patients

Gregorio, Miguel Ángel De; Ruiz, C.; Alfonso, E.R.; Fernández, José Antonio; Medrano, J.; Ariño, I.

doi:10.1007/s002709900345

Cited by 15 publications

(3 citation statements)

References 29 publications

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“…We have used repeat doses of 100,000 IU for the treatment of pleural empyema and abdominal abscess with satisfactory results [16,32], following the guidelines published by Moulton et al [33].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous treatment of intrabdominal abscess: urokinase versus saline serum in 100 cases using two surgical scoring systems in a randomized trial

et al. 2009

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The purpose of this study was to assess whether regular instillation of urokinase during abscess drainage leads to an improved outcome compared to saline irrigation alone. One hundred patients referred for image-guided abdominal abscess drainage were randomized between thrice daily urokinase instillation or saline irrigation alone. At the end of the study, patient medical records were reviewed to determine drainage, study group, Altona (PIA II) and Mannheim (MPI) scoring, duration of drainage, procedure-related complications, hospital stay duration, and clinical outcome. The technical success rate of the percutaneous abscess drainage was 100%. The success or failure of abscess remission did not differ significantly between groups (success rate of 91.5% in the urokinase group vs. 88.8% in the saline group; failure rate was of 8.5 vs. 21.2%, respectively); however, days of drainage, main hospital stay, and overall costs were significantly reduced in patients treated with urokinase compared to the control group (P < 0.05). No adverse effects from urokinase were observed. Surgical scores were a useful homogeneity factor, and MPI showed a good correlation with prognosis, while PIA results did not have a significant correlation. For drainage of complex abscesses (loculations, hemorrhage, viscous material), fibrinolytics safely accelerate drainage and recovery, reducing the length of the hospital stay and, therefore, the total cost.

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Section: Discussionmentioning

confidence: 99%

Percutaneous treatment of intrabdominal abscess: urokinase versus saline serum in 100 cases using two surgical scoring systems in a randomized trial

et al. 2009

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“…Streptokinase, urokinase and other thrombolytic agents have been used to improve pleural drainage in multi-loculated pleural effusions secondary to infection for some time and it appears a safe technique [95,96].…”

Section: Thrombolytic Therapymentioning

confidence: 99%

Chemotherapeutic management of malignant pleural effusion

Antunes

2004

Expert Opinion on Pharmacotherapy

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The management of malignant pleural effusions are a common, and sometimes difficult, therapeutic problem. This article reviews the currently available sclerosing agents and discusses novel agents that show promise for the future. Talc, tetracycline and bleomycin are currently the most widely used agents but none is an ideal sclerosant and certain adverse effects are of concern. Novel agents, particularly transforming growth factor (TGF)-beta(2) and metalloproteinase inhibitors, are being investigated, and the increase in knowledge into the mechanisms of pleural fluid formation and pleurodesis will hopefully lead to the development of targeted therapy in the future.

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“…Small (21 gauge) cutting needles that produce specimens for histologic analysis have been employed in children and have shown morbidity similar to that seen with fine-needle aspiration techniques. 40 Biopsies of larger masses in the mediastinum and chest wall can usually be performed safely with cutting needles (i.e., True Cut [Baxter] or Temno [Allegiance] instruments) because the lung and pleural surfaces can typically be avoided. Fine-needle aspirates are usually sufficient to obtain the diagnosis in inflammatory diseases.…”

Section: Biopsymentioning

confidence: 99%

Interventional Procedures in the Pediatric Chest: Biopsy and Drainage

Norman¹,

Donaldson²

2002

Semin intervent Radiol

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Interventional procedures in the adult chest are well described and practiced. Many of the same procedures, although somewhat less commonly employed, also apply in pediatric settings. In the realm of chest intervention, probably the biggest impact in pediatric disease has been the percutaneous drainage of empyema and parenchymal abscesses. In this article, techniques, with emphasis on special applications in regard to children, and sedations appropriate for various intrathoracic procedures, highlighting percutaneous drainage, are discussed.Objectives: On completion of this article, the reader will be able to (1) list some of the more common regimens used for sedating the child undergoing a procedure involving the thorax and (2) summarize the steps involved in performing drainages and biopsies within the chests of children. Accreditation: Tufts University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. TUSM takes full responsibility for the content, quality, and scientific integrity of this continuing education activity. Credit: Tufts University School of Medicine designates this education activity for a maximum of 1.0 hour credit toward the AMA Physicians Recognition Award in category one. Each physician should claim only those hours that he/she actually spent in the educational activity.with an emphasis on procedure and how they apply to the pediatric population.Downloaded by: University of Michigan. Copyrighted material.

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Transcatheter intracavitary fibrinolysis of loculated pleural effusions: Experience in 102 patients

Abstract: The use of intrapleural fibrinolytic agents delivered through small-caliber catheters for the treatment of loculate and/or septate pleural effusion is a simple, effective, minimally invasive and inexpensive procedure that can prevent sequelae and shorten drainage time.

Cited by 15 publications

References 29 publications

Percutaneous treatment of intrabdominal abscess: urokinase versus saline serum in 100 cases using two surgical scoring systems in a randomized trial

Percutaneous treatment of intrabdominal abscess: urokinase versus saline serum in 100 cases using two surgical scoring systems in a randomized trial

Chemotherapeutic management of malignant pleural effusion

Interventional Procedures in the Pediatric Chest: Biopsy and Drainage

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