2015
DOI: 10.1016/j.hlc.2014.12.163
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Transcatheter Aortic Valve Implantation (TAVI) in Patients With Bicuspid Aortic Valve Stenosis – Systematic Review and Meta-Analysis

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Cited by 52 publications
(40 citation statements)
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“…Moreover, no difference was found in post-TAVI mean peak gradients, grading of paravalvular leaks (moderate or severe) (25.7% vs. 19.9% respectively, P = 0.29), PMK implantations rate (18.5% vs. 27.9%, P = 0.52), life-threatening bleeding (8.2% vs. 13.9%, P = 0.33) and major bleeding (20% vs. 16.8%, P = 0.88). Furthermore, need for conventional open-heart surgery (1.9% for BAV group and 1.2% for TAV group, P = 0.18) and occurrence of vascular complications (8.6% and 10.1% respectively, P = 0.32) were also comparable between the two groups [39] . Confirming these findings, Sannino et al [40] investigated the efficacy and safety of TAVI in BAV population.…”
Section: Patients With Bicuspid Aortic Valvementioning
confidence: 73%
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“…Moreover, no difference was found in post-TAVI mean peak gradients, grading of paravalvular leaks (moderate or severe) (25.7% vs. 19.9% respectively, P = 0.29), PMK implantations rate (18.5% vs. 27.9%, P = 0.52), life-threatening bleeding (8.2% vs. 13.9%, P = 0.33) and major bleeding (20% vs. 16.8%, P = 0.88). Furthermore, need for conventional open-heart surgery (1.9% for BAV group and 1.2% for TAV group, P = 0.18) and occurrence of vascular complications (8.6% and 10.1% respectively, P = 0.32) were also comparable between the two groups [39] . Confirming these findings, Sannino et al [40] investigated the efficacy and safety of TAVI in BAV population.…”
Section: Patients With Bicuspid Aortic Valvementioning
confidence: 73%
“…Of note, despite the higher risk for relevant AR among patients with BAV compared with those with TAV, 30-day and 1-year mortality rates were similar in both subsets of patients [38] . A systematic review and meta-analysis conducted by Phan et al [39] analyzed seven studies including a total of 2245 patients (149 with BAV and 2096 with TAV) undergoing TAVI. According to their results, no difference was observed in 30-day mortality between BAV and TAV groups.…”
Section: Patients With Bicuspid Aortic Valvementioning
confidence: 99%
“…An analysis of 139 low‐ and intermediate‐risk patients (mean STS score 4.9±3.4%) in 12 European centers corroborated these findings with 1‐year mortality of 17.5% 36. Another multicenter observational study comparing TAVR in patients with bicuspid versus tricuspid aortic valves did not demonstrate any difference in 30‐day mortality 40. A comparison of outcomes in high‐risk patients with bicuspid versus tricuspid aortic valves from the German national TAVR registry also demonstrated no difference in 1‐year mortality 39.…”
Section: Do Clinical Trials Of Tavr In Low‐risk Patients Herald the Ementioning
confidence: 75%
“…[8] In registry reviews, patients with BAV who underwent TAVR had much higher risks of paravalvular leakage, malpositioning or migration, perhaps due to their elliptical annular anatomy, irregular (often severe) annular-leaflet calcifications, and possible less holding-wrapping resistance on the implanted valve than in tricuspid aortic valves. [9] Moderate-to-severe paravalvular leakage in BAV patients were more common than non-BAV patients. [9] Mylotte et al [10] found the moderate-to-severe aortic regurgitation incidence as high as 28.4% in BAV patients, while it was only 9% in CoreValve ® pivotal trial, and 12.2% in Partner 1A trial.…”
Section: Discussionmentioning
confidence: 90%
“…[9] Moderate-to-severe paravalvular leakage in BAV patients were more common than non-BAV patients. [9] Mylotte et al [10] found the moderate-to-severe aortic regurgitation incidence as high as 28.4% in BAV patients, while it was only 9% in CoreValve ® pivotal trial, and 12.2% in Partner 1A trial. The annular diameters or working mechanisms of the currently available catheter-based valves may not be always compatible with the calcified and deformed shape of the BAV.…”
Section: Discussionmentioning
confidence: 90%