Transamination Reaction in Normal and B6-Deficient Hamsters

Studies on Certain Hepatic Enzymes and Protein Biosynthesis in Pyridoxine Deficient Rats

“…The reduced activity of this enzyme as well as the observed decrease in activity of that succinate dehydrogenase might have been due to the observed derangement in protein biosynthesis caused by pyridoxine deficiency (18). The decrease in AlT activity in pyrido xine deficiency is in accordance with some of the earlier findings (8)(9)(10)(11)(12)(13)(14)(15).…”

“…A number of investigators (8)(9)(10)(11)(12)(13)(14)(15) have reported that the pyridoxine deficiency depresses transaminase activity in various species, since pyridoxal phos phate acts as a coenzyme in the transaminase system. Role of pyridoxine in protein biosyn thesis has been already reported by Orekhovich (16) and Trakatellis et al (17).…”

Influence of vitamin B6 deficiency on selected aspects of metabolism in the chick

“…The changes in transaminase activity were found to parallel the changes in growth when vitamin B^ was withheld or returned to the diet. Similar results were later observed by Schwartzman and Hift (1951) in studying transamination in normal and B^-deficient hamsters. These workers also pointed out that the transamination rate of heart muscle of B^-deficient hamsters was 30 to 40 percent lower than that of control ad libitum-fed or pair-fed animals.…”