Studies on Certain Hepatic Enzymes and Protein Biosynthesis in Pyridoxine Deficient Rats

The present study included 2 trials which were performed to investigate in which way graded vitamin B6 supplies or vitamin B6 deficiency would influence the chemical composition of the whole body, the liver, pectoral muscle or the eggs of hens and in which way it might change the pattern of amino acid composition in the proteins of the pectoral muscle. The following results were obtained: No direct changes in the protein and fat content of the birds (total body, liver, pectoral muscle) were noted in trial 1 when graded amounts of vitamin B6 were supplied, whereas in trial 2 signifikant increases in the fat content of the body and decrases in the protein levels were observed when vitamin B6 supplements were added to a vitamin-deficient diet (pair-fed group) or fed to animals receiving increased amounts of food (controls). Variations in dietary vitamin B6 concentrations did not produce statistically significant changes in the protein and fat content of eggs, and in the pattern of amino acid composition of proteins in the pectoral muscle. However, with increasing vitamin B6 uptake, the serine to glycine ratio was narrowed.

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Assessment of vitamin B6 status. Studies on pregnant women and oral contraceptive users

Shane¹,

Contractor²

1975

The American Journal of Clinical Nutrition

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The vitamin B6 status of 10 pregnant women (third trimester), 9 oral contraceptive agent users, and 12 notnpregnant women (controls) was investigated over a 10-week period by means of the erythrocyte glutamate-oxaloacetate transaminase (E-GOT) activation test and by measurements of whole blood pyridoxal phosphate levels. Blood pyridoxal phosphate levels in oral contraceptive agent users (7.6 plus or minus 1.1 ng/ml) were significantly lower than in the control group (9.6 plus or minus 1.7 mg/ml)indicating a relative vitamin B6 deficiency. Pyridoxal phosphate levels in pregnant women(5.1 plus or minus 1.3ng/ml) were even lower; in fact, no overlap was found in individual mean values between the pregnant and control groups. The E-GOT activation test did not indicate a vitamin deficiency in the pregnant women or in oral contraceptive agent users and the E-GOT activation factor did not correlate with blood pyridoxal phosphate levels unless results obtained after pyridoxine hydrochloride (20 mg/day) administration were included. The E-GOT activation test appears to be a poor indicator of vitamin B6 status, except in pronounced deficiency as it is less responsive to vitamin depletion than blood pyridoxal phosphate levels, and suffers from relatively large variations in individual control values. This may be a result of factors unrelated to vitamin B6 as blood pyridoxal phosphate levels remained fairly constant in the individuals investigated.

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Studies on Certain Hepatic Enzymes and Protein Biosynthesis in Pyridoxine Deficient Rats

Abstract: Protein biosynthesis, using 14C-serine and related aspects in pyridoxine deficient rats were studied. The following results were obtained.

Cited by 4 publications

References 11 publications

Effect of vitamin B6 deficiency on pancreatic acinar cell function

Effect of vitamin B6 deficiency on pancreatic acinar cell function

Untersuchungen zum Einfluß einer differenzierten Vitamin-B₆-Aufnahme der Henne auf den Nährstoffgehalt von Leber, Brustmuskel, Gesamtkürper und Ei

Assessment of vitamin B6 status. Studies on pregnant women and oral contraceptive users

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Studies on Certain Hepatic Enzymes and Protein Biosynthesis in Pyridoxine Deficient Rats

Abstract: Protein biosynthesis, using 14C-serine and related aspects in pyridoxine deficient rats were studied. The following results were obtained.

Cited by 4 publications

References 11 publications

Effect of vitamin B6 deficiency on pancreatic acinar cell function

Effect of vitamin B6 deficiency on pancreatic acinar cell function

Untersuchungen zum Einfluß einer differenzierten Vitamin-B6-Aufnahme der Henne auf den Nährstoffgehalt von Leber, Brustmuskel, Gesamtkürper und Ei

Assessment of vitamin B6 status. Studies on pregnant women and oral contraceptive users

Contact Info

Product

Resources

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Untersuchungen zum Einfluß einer differenzierten Vitamin-B₆-Aufnahme der Henne auf den Nährstoffgehalt von Leber, Brustmuskel, Gesamtkürper und Ei