2005
DOI: 10.3748/wjg.v11.i25.3893
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Transactivating effect of complete S protein of hepatitis B virus and cloning of genes transactivated by complete S protein using suppression subtractive hybridization technique

Abstract: Abstract Abstract Abstract AIM:To investigate the transactivating effect of complete S protein of hepatitis B virus (HBV) and to construct a subtractive cDNA library of genes transactivated by complete S protein of HBV by suppression subtractive hybridization (SSH) technique and to clone genes associated with its transactivation activity, and to pave the way for elucidating the pathogenesis of hepatitis B virus infection. METHODS:pcDNA3.1(-)-complete S containing full-length HBV S gene was constructed by inser… Show more

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Cited by 4 publications
(2 citation statements)
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References 25 publications
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“…CSTP1 gene was first identified by Bai GQ in 2005 [15], which was transactived by complete S protein of hepatitis B virus, and we supposed it may be associated with human cancers. We first examined CSTP1 mRNA expression level in several kinds of human cancers, including liver, pancreas, stomach, colon, bladder and renal cancers.…”
Section: Resultsmentioning
confidence: 91%
See 1 more Smart Citation
“…CSTP1 gene was first identified by Bai GQ in 2005 [15], which was transactived by complete S protein of hepatitis B virus, and we supposed it may be associated with human cancers. We first examined CSTP1 mRNA expression level in several kinds of human cancers, including liver, pancreas, stomach, colon, bladder and renal cancers.…”
Section: Resultsmentioning
confidence: 91%
“…Here, we reported a novel protein phosphatase, termed the complete s transactivated protein 1(CSTP1) [15], whose expression was selectively reduced in non-muscle invasive bladder cancers. To make a further understand of the significance of CSTP1 in bladder carcinogenesis, in this study, we will go deep insight into i. the effects of CSTP1 on bladder cancer cell cycle, apoptosis and tumor formation in vivo and the underlined molecular mechanisms; ii.…”
Section: Introductionmentioning
confidence: 99%