2006
DOI: 10.1016/j.virusres.2005.10.023
|View full text |Cite
|
Sign up to set email alerts
|

Alternative peptide-fusion proteins generated by out-of-frame mutations, just upstream ORFs or elongations in mutants of Human Hepatitis B Viruses

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
9
0

Year Published

2006
2006
2023
2023

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 13 publications
(9 citation statements)
references
References 87 publications
0
9
0
Order By: Relevance
“…There are two principal types of overlap: (1) the same-strand type in which the two genes involved are transcribed from the same strand but in different reading frames and (2) the different-strand type in which the two genes are transcribed from different strands. Overlapping genes are known to be common in viruses, mitochondria, bacteria, plasmids and even in vertebrates (references in [50,51]). However, with the exception of viruses [52], it is widely assumed that only one strand can encode a protein and that the non-coding strands do not, although they can play a role in regulation [53].…”
Section: Discussionmentioning
confidence: 99%
“…There are two principal types of overlap: (1) the same-strand type in which the two genes involved are transcribed from the same strand but in different reading frames and (2) the different-strand type in which the two genes are transcribed from different strands. Overlapping genes are known to be common in viruses, mitochondria, bacteria, plasmids and even in vertebrates (references in [50,51]). However, with the exception of viruses [52], it is widely assumed that only one strand can encode a protein and that the non-coding strands do not, although they can play a role in regulation [53].…”
Section: Discussionmentioning
confidence: 99%
“…The global prevalence of chronic hepatitis B virus (HBV) infection is estimated at 240 million infections, and these infections contribute to ∼600,000 deaths annually due to complications such as liver failure, cirrhosis, and hepatocellular carcinorma [Ott et al, ]. HBV is an enveloped, 3.2 kb partially double‐stranded DNA virus, which belongs to the Hepadnaviridae family [Faure, ]. Like retroviruses, HBV also uses a reverse transcriptase enzyme during replication, resulting in high HBV diversity [Olinger et al, ].…”
Section: Introductionmentioning
confidence: 99%
“…In a subgroup of Theiler's murine encephalomyelitis virus, translation of an ARF produces a protein that appears to increase demyelinating activity (64) and may also play a role in cell tropism, thus restricting infection to cell populations that serve as reservoirs for the virus (65). Variations in the hepatitis B virus genome have revealed cryptic ORFs encoding long ARF sequences associated predominantly with patients demonstrating severe disease, suggesting a role of these sequences in viral pathogenesis (66).…”
Section: Impact Of Cryptic Epitopes On T Cell Selection and Immunitymentioning
confidence: 99%