Transabdominal chorionic villus sampling and amniocentesis for prenatal diagnosis: 5 years' experience at a University Centre

Abstract

The fetal loss rates and fetal congenital birth defects in 821 transabdominal (TA) chorionic villus sampling (CVS) and 771 amniocentesis (AC) cases were evaluated from a 5-year period (1987-1991) at the University Central Hospital of Turku. The parents were given the option of choosing between the two sampling procedures. CVS was performed, in most cases, at 11 weeks of gestation; and AC, at 15 weeks. The rate of total post-procedure loss was 6.7 per cent in the CVS group and 4.4 per cent in the AC group (p = 0.08). The rate of spontaneous abortions was 1.9 per cent in the CVS group and 1.0 per cent in the AC group (p = 0.10). The number of birth defects was low in both study groups. No limb reduction cases were observed. Mosaicism was noted in 14 CVS cases and in five AC cases. We conclude that TA-CVS is a safe and practical alternative to AC in prenatal fetal karyotyping.

Women's knowledge, concerns and psychological reactions before undergoing an invasive procedure for prenatal karyotyping

“…Therefore, we believe that our results reflect how women experience the situation prior to any kind of invasive procedure. For a majority of the women (75.5%), the reason for having an invasive procedure was advanced maternal age, a finding in accordance with previous studies presenting figures of 78 to 92% 1,10,11 . In the present study, anxiety was a major reason for a rather high proportion of women (38.3%) compared with 3.2% reported by Nevin and associates 11 , and 2.7% reported by Hanson and associates 10 .…”

“…Today, amniocentesis performed in the 16th week of pregnancy, chorionic villus sampling (CVS), or early amniocentesis performed in the late first or early second trimester are available. Traditionally, maternal age has been the dominant reason for having an invasive test 1 . Studies to evaluate the consequences of invasive procedures have concentrated mainly on diagnostic accuracy and the risk of fetal loss.…”

First 10 000 chorionic villus samplings performed on singleton pregnancies by a single operator

“…Clinicians can thus take advantage of the developments in recombinant DNA technology, broadening the range of gene defects that can be detected prenatally. Most large reports on CVS either represent collaborative efforts or are from centres in which at least two or more operators of different technical levels have contributed to the clinical experience (Canadian Collaborative CVS-Amniocentesis Clinical Trial Group, 1989;Jahoda et al, 1989;Rhoads et al, 1989;Hallak et al, 1992;Jackson et al, 1992; MRC Working Party on the Evaluation of Chorionic Villus Sampling, 1991;Smidt-Jensen et al, 1992;Williams et al, 1992;Ammala et al, 1993;Jackson and Wapner, 1993;Palo et al, 1994;Lunshof et al, 1995). Details of a large experience by a single operator should further delineate the potential of CVS.…”

Synthesis of Evidence from Epidemiological Studies with Interval-Censored Exposure Due to Grouping

“…The models defined by (3.2) and (3.4) or (3.2) and ( 3 6 ) were specified for a single study involving both diseased and disease-free subjects. The interpretations of the parameters differ in the various study designs, however, and any data synthesis must Mastroiacovo et al (1994) NA NA 6 9 10 10 11 16 Olney et al (1995) NA NA 8 9 10 10 11 12 Dolk et al (1992) NA NA 6 16 9 9 10 10 11 11 Nicolaides et al (1994) 8 13 Palo et al (1994) 10 14 recognize this. In the Appendix, we examine the impact of selection effects on the parameters under the various designs.…”