Trajectories of the Hippocampal Subfields Atrophy in the Alzheimer’s Disease: A Structural Imaging Study

Zhao, Weina; Wang, Xuetong; Yin, Changhao; He, Mengfei; Li, Shuyu; Han, Ying

doi:10.3389/fninf.2019.00013

Cited by 105 publications

(100 citation statements)

References 45 publications

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“…Our results were supported by previous studies, which reported that the subiculum and CA1 related with cognition in T2DM rat and human [38,43,44]. A structural imaging study in patients with subjective cognitive decline found volume reductions in the presubiculum, molecular layer and fimbria [19]. Another study in a large population-based cohort reported smaller volumes of the hippocampal fimbria, presubiculum and subiculum that was related to a risk of dementia [45].…”

Section: Discussionsupporting

confidence: 91%

“…Free-Surfer is a freely available voxel-based software package that provides extensive and automated neuroimaging analysis [15]. Compared with manual segmentation, FreeSurfer is highly efficient, accurate [16,17], and has been successfully used to precisely segment the hippocampus [18][19][20][21]. A recent study in AD patients found that atrophy of the left subiculum correlated with cognitive disorders [19].…”

Section: Introductionmentioning

confidence: 99%

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Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Huang

Yang

et al. 2020

Endocrine

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Purpose To identify the volume changes of hippocampus subfields in T2DM patients with cognitive impairment and to determine how these atrophy patterns associate with impairments in different cognitive domain. Methods A total of 117 individuals were recruited, including T2DM patients with cognitive impairment (T2DM-CI) (n = 34), T2DM patients without cognitive impairment (T2DM-non-CI) (n = 36) and normal controls (NC) (n = 47). All subjects went through a 3.0 T magnetic resonance (MR) scan and a neuropsychological assessment. Hippocampal subfield volumes were processed using the FreeSurfer 6.0.0 and compared among the three groups. Partial correlation analyses were used to estimate the relationship between cognitive function and hippocampal subfield volume, with age, sex, education, and eTIV (estimated total intracranial volume) as covariants. Results The total hippocampal volume had a reduction trend among the three groups, and the significantly statistical difference only was found between T2DM-CI group and NC group. Regarding the hippocampal subfields, the volumes of left subiculum, left presubiculum, left fimbria, right CA1 and right molecular layer HP decreased significantly in the T2DM-CI group (P < 0.05/12). Partial correlation analyses showed that the volumes of the left subiculum, left fimbria, and left presubiculum were significantly related to executive function. The right hippocampal CA1 volume was significantly correlated with memory in the T2DM-CI group (P < 0.05). But in T2DM-non-CI group, the correlation between the left fimbria volume and the memory, the left subiculum volume and MoCA were different with the T2DM-CI group and NC group (P < 0.05). Conclusions The smaller the volume of left presubiculum, the worse the executive function, and the atrophy of the right CA1 was related to memory impairment in T2DM-CI group. However the result was the opposite in T2DM-non-CI group. There might be a compensation mechanism of hippocampus of T2DM patients before cognitive impairment.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Huang

Yang

et al. 2020

Endocrine

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“…These neurotoxicological data collectively suggest that some hippocampal subfields may be more sensitive than others to the adverse PM-effects. Additionally, human imaging studies (Zhao et al, 2019) have found that atrophy in hippocampal subfields imposed varying degrees of influences on different measures of episodic memory (immediate recalls; delayed-recalls; recognition). Previous research also suggests that the CA2, CA3, and dentate gyrus are responsible for encoding, while the CA1 and subiculum are responsible for retrieval (Zammit et al, 2017).…”

Section: Sensitivity Analysesmentioning

confidence: 99%

Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease

Younan

Petkus

Widaman

et al. 2019

Brain

149

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Evidence suggests exposure to particulate matter with aerodynamic diameter <2.5 μm (PM2.5) may increase the risk for Alzheimer’s disease and related dementias. Whether PM2.5 alters brain structure and accelerates the preclinical neuropsychological processes remains unknown. Early decline of episodic memory is detectable in preclinical Alzheimer’s disease. Therefore, we conducted a longitudinal study to examine whether PM2.5 affects the episodic memory decline, and also explored the potential mediating role of increased neuroanatomic risk of Alzheimer’s disease associated with exposure. Participants included older females (n = 998; aged 73–87) enrolled in both the Women’s Health Initiative Study of Cognitive Aging and the Women’s Health Initiative Memory Study of Magnetic Resonance Imaging, with annual (1999–2010) episodic memory assessment by the California Verbal Learning Test, including measures of immediate free recall/new learning (List A Trials 1–3; List B) and delayed free recall (short- and long-delay), and up to two brain scans (MRI-1: 2005–06; MRI-2: 2009–10). Subjects were assigned Alzheimer’s disease pattern similarity scores (a brain-MRI measured neuroanatomical risk for Alzheimer’s disease), developed by supervised machine learning and validated with data from the Alzheimer’s Disease Neuroimaging Initiative. Based on residential histories and environmental data on air monitoring and simulated atmospheric chemistry, we used a spatiotemporal model to estimate 3-year average PM2.5 exposure preceding MRI-1. In multilevel structural equation models, PM2.5 was associated with greater declines in immediate recall and new learning, but no association was found with decline in delayed-recall or composite scores. For each interquartile increment (2.81 μg/m3) of PM2.5, the annual decline rate was significantly accelerated by 19.3% [95% confidence interval (CI) = 1.9% to 36.2%] for Trials 1–3 and 14.8% (4.4% to 24.9%) for List B performance, adjusting for multiple potential confounders. Long-term PM2.5 exposure was associated with increased Alzheimer’s disease pattern similarity scores, which accounted for 22.6% (95% CI: 1% to 68.9%) and 10.7% (95% CI: 1.0% to 30.3%) of the total adverse PM2.5 effects on Trials 1–3 and List B, respectively. The observed associations remained after excluding incident cases of dementia and stroke during the follow-up, or further adjusting for small-vessel ischaemic disease volumes. Our findings illustrate the continuum of PM2.5 neurotoxicity that contributes to early decline of immediate free recall/new learning at the preclinical stage, which is mediated by progressive atrophy of grey matter indicative of increased Alzheimer’s disease risk, independent of cerebrovascular damage.

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“…For example, decreased amyloid beta protein 42 (Aβ-42) and elevated tau level in CSF were found in patients with SCD (Visser et al, 2009). SCD patients also tend to present AD/aMCI-like gray matter atrophy, decreased metabolism, and increased amyloid load, especially in the hippocampus Zhao et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline

Luo

Qin

et al. 2020

Front. Aging Neurosci.

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Background and Objective: Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer's disease (AD) and may represent a more advanced preclinical status than amnestic mild cognitive impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure and their correlation with cognitive function in these AD-spectrum patients.Methods: Diffusion tensor images from 43 individuals with normal cognition (NC), 38 SCD patients, and 36 aMCI patients were compared using an atlas-based segmentation strategy. The correlation between diffusion parameters and cognitive function was further analyzed.Results: The anatomical pattern of WM impairment was generally similar between SCD and aMCI patients. However, aMCI patients showed significantly lower fractional anisotropy (i.e., corpus callosum forceps major and forceps minor) and increased mean diffusivity [i.e., bilateral anterior thalamic radiation (ATR), left corticospinal tract (CST), forceps minor, left cingulum (cingulate gyrus), left cingulum hippocampus, and left inferior fronto-occipital fasciculus (IFO)] in some tracts than did SCD subjects, indicating a disruption in WM microstructural integrity in the aMCI. Individuals with microstructural disruption in forceps minor, left cingulum (cingulate gyrus), and left cingulum hippocampus tracts performed worse in general cognition and memory function tests, as indicated by line regression analysis.Conclusion: SCD individuals had extensive WM microstructural damage in a pattern similar to that seen in aMCI, although presenting a cognitive performance comparable with that of cognitively healthy individuals. Our results suggest that WM integrity might precede objectively measurable memory decline and may be a potential early biomarker for AD.

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Trajectories of the Hippocampal Subfields Atrophy in the Alzheimer’s Disease: A Structural Imaging Study

Cited by 105 publications

References 45 publications

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease

White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline

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