Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Li, MengChun; Huang, Lili; Yang, Dan; Luo, Caimei; Qin, Ruomeng; Zhang, Bing; Zhao, Hui; Xu, Yun

doi:10.1007/s12020-020-02249-w

Cited by 20 publications

(14 citation statements)

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“…Anatomically, atrophied structures, including the presubiculum and parasubiculum, were situated at the medial portions of the hippocampus, while the molecular layer of the HP, CA1 and HATA were situated at the lateral portions. In fact, the volume of the presubiculum or parasubiculum, which is related to cognitive level, has been found to be decreased in many diseases, such as Parkinson’s disease, diabetes and Alzheimer’s disease ( Low et al, 2019 ; Zhao et al, 2019 ; Li et al, 2020 ). The presubiculum and parasubiculum play an important role in cognitive processing and visual spatial function ( Low et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Deviations in Hippocampal Subregion in Older Adults With Cognitive Frailty

Wan

Lin

et al. 2021

Front. Aging Neurosci.

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BackgroundCognitive frailty is a particular state of cognitive vulnerability toward dementia with neuropathological hallmarks. The hippocampus is a complex, heterogeneous structure closely relates to the cognitive impairment in elderly which is composed of 12 subregions. Atrophy of these subregions has been implicated in a variety of neurodegenerative diseases. The aim of this study was to explore the changes in hippocampal subregions in older adults with cognitive frailty and the relationship between subregions and cognitive impairment as well as physical frailty.MethodsTwenty-six older adults with cognitive frailty and 26 matched healthy controls were included in this study. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA) scale (Fuzhou version) and Wechsler Memory Scale-Revised Chinese version (WMS-RC), while physical frailty was tested with the Chinese version of the Edmonton Frailty Scale (EFS) and grip strength. The volume of the hippocampal subregions was measured with structural brain magnetic resonance imaging. Partial correlation analysis was carried out between the volumes of hippocampal subregions and MoCA scores, Wechsler’s Memory Quotient and physical frailty indexes.ResultsA significant volume decrease was found in six hippocampal subregions, including the bilateral presubiculum, the left parasubiculum, molecular layer of the hippocampus proper (molecular layer of the HP), and hippocampal amygdala transition area (HATA), and the right cornu ammonis subfield 1 (CA1) area, in older adults with cognitive frailty, while the proportion of brain parenchyma and total number of white matter fibers were lower than those in the healthy controls. Positive correlations were found between Wechsler’s Memory Quotient and the size of the left molecular layer of the HP and HATA and the right presubiculum. The sizes of the left presubiculum, molecular of the layer HP, and HATA and right CA1 and presubiculum were found to be positively correlated with MoCA score. The sizes of the left parasubiculum, molecular layer of the HP and HATA were found to be negatively correlated with the physical frailty index.ConclusionSignificant volume decrease occurs in hippocampal subregions of older adults with cognitive frailty, and these changes are correlated with cognitive impairment and physical frailty. Therefore, the atrophy of hippocampal subregions could participate in the pathological progression of cognitive frailty.

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Section: Discussionmentioning

confidence: 99%

Deviations in Hippocampal Subregion in Older Adults With Cognitive Frailty

Wan

Lin

et al. 2021

Front. Aging Neurosci.

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“…Dopaminergic projection to hippocampus participates in cognitive function in PD (Jokinen et al 2009). The CA1 region of the hippocampus is involved in cognitive processes, particularly learning, and memory (Li et al 2020), and which along with CA3, forms the hippocampal Schaffer collateral pathway, is one of the most studied hippocampal synaptic pathway (Zamora-Moratalla and Martín 2021). Dopamine (DA) released from dopaminergic neurons plays important roles in synaptic plasticity processes.…”

Section: Introductionmentioning

confidence: 99%

Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling

Huan

Wang

et al. 2022

Metab Brain Dis

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Paeoniflorin (PF) has numerous benefits, including anti-inflammatory and anti-apoptosis effects. However, it is not clear if it has neuroprotective effects against cognitive impairment (CI) in Parkinson’s disease (PD). Through network pharmacology, we identified probable targets as well as signal pathways through which PF might affect CI in PD. Then, we experimentally validated our findings. The core genes of the protein-protein interactions (PPI) network include MAPK8 (JNK), TP53, CASP3 (caspase-3), postsynaptic density protein-95 (PSD-95) and synaptophysin (SYN). Pathway enrichment analysis revealed that genes involved in apoptosis and mitogen-activated protein kinase (MAPK) signaling were significantly enriched. Because JNK is a key mediator of p53-induced apoptosis, we wondered if JNK/p53 pathway influences the effects of PF against apoptosis in mouse model of PD. Molecular docking analysis showed that PF had good affinity for JNK/p53. The results of the experiments indicated that PF ameliorated behavioral impairments and upregulated the expression of the dopamine (DA) neurons, suppressed cell apoptosis in substantia nigra pars compacta (SNpc) of PD. Additionally, PF improved 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuronal injury by inhibiting apoptosis in hippocampal neurons of the CA1 and CA3, and upregulating PSD-95 as well as SYN protein levels. Similar protective effects were observed upon JNK/p53 pathway inhibition using SP600125. Overall, PF improved CI in PD by inhibiting JNK/p53 pathway.

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“…Anatomically, atrophied structures, including the presubiculum and parasubiculum, were situated at the medial portions of the hippocampus, while the molecular layer of the HP, CA1 and HATA were situated at the lateral portions. In fact, the volume of the presubiculum or parasubiculum, which is related to cognitive level, has been found to be decreased in many diseases, such as Parkinson's disease, diabetes and Alzheimer's disease [24][25][26]. The presubiculum and parasubiculum play an important role in cognitive processing and visual spatial function [24].…”

Section: Discussionmentioning

confidence: 99%

Deviations in Hippocampal Subregion Associated With Cognitive and Physical Frailty in Older Adults With Cognitive Frailty

Wan¹,

Ye²,

Lin³

et al. 2020

Preprint

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Background The hippocampus is a complex, heterogeneous structure that is composed of widely different and interacting subregions. Atrophy of these subregions has been implicated in a variety of neurodegenerative diseases. Cognitive frailty is a kind of neurodegenerative disease with unclear neuropathological changes. The aim of this study was to explore the changes in hippocampal subregions in older adults with cognitive frailty and the relationship between subregions and cognitive decline as well as physical frailty.Methods Twenty-six older adults with cognitive frailty and 26 matched healthy controls were included in this study. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA) scale (Fuzhou version) and Wechsler's Memory Scale, while physical frailty was tested with the Chinese version of the Edmonton Frailty Scale (EFS) and grip strength. The volume of the hippocampal subregions was measured with structural brain magnetic resonance imaging. Partial correlation analysis was carried out between the volumes of hippocampal subregions and MoCA scores, Wechsler’s Memory Quotient and physical frailty indexes.Results A significant volume decrease was found in six hippocampal subregions, including the bilateral presubiculum, the left parasubiculum, molecular layer of the HP, and HATA, and the right CA1 area, in older adults with cognitive frailty (P<0.05/12), while the proportion of brain parenchyma and total number of white matter fibers were lower than those in the healthy controls (P<0.05). Positive correlations were found between Wechsler’s Memory Quotient and the size of the left molecular layer of the HP and HATA and the right presubiculum (P<0.05). The sizes of the left presubiculum, molecular of the layer HP, and HATA and right CA1 and presubiculum were found to be positively correlated with MoCA score (P<0.05). The sizes of the left parasubiculum, molecular layer of the HP and HATA were found to be negatively correlated with the physical frailty index (P<0.05).Conclusion Significant volume decrease occurs in hippocampal subregions of older adults with cognitive frailty, and these changes are correlated with cognitive decline and physical frailty. Therefore, the atrophy of hippocampal subregions could participate in the pathological progression of cognitive frailty.

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Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Cited by 20 publications

References 50 publications

Deviations in Hippocampal Subregion in Older Adults With Cognitive Frailty

Deviations in Hippocampal Subregion in Older Adults With Cognitive Frailty

Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling

Deviations in Hippocampal Subregion Associated With Cognitive and Physical Frailty in Older Adults With Cognitive Frailty

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