White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline

Luo, Caimei; Li, Mengchun; Qin, Ruomeng; Chen, Haifeng; Yang, Dan; Huang, Lili; Liu, Renyuan; Xu, Yun; Bai, Feng; Zhao, Hui

doi:10.3389/fnagi.2019.00378

Cited by 48 publications

(50 citation statements)

References 46 publications

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“…In the elderly with normal cognition, the connection between the occipital lobe and the posterior cingulate and precuneus is related to the tau protein, which may change in preclinical cognitive impairment (Quevenco et al, 2020). In patients with subjective cognitive decline, white matter damage across the frontal and occipital lobes was also found; this track is thought to be related to the gray matter damage such as the medial prefrontal cortex and posterior cingulate cortex in the early stage of AD (Luo et al, 2019). The close connection between the occipital lobe and the frontal lobe is consistent with finding abnormal functional activity in both the orbitofrontal cortex and the occipital cortex in our study.…”

Section: Similar Pattern Between the Obj-scd And Amci Groupsmentioning

confidence: 99%

Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline

Cui

Zhang

et al. 2021

Front. Aging Neurosci.

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Introduction: To identify individuals with preclinical cognitive impairment, researchers proposed the concept of objectively-defined subtle cognitive decline (Obj-SCD). However, it is not clear whether Obj-SCD has characteristic brain function changes. In this study, we aimed at exploring the changing pattern of brain function activity in Obj-SCD individuals and the similarities and differences with mild cognitive impairments (MCI).Method: 37 healthy control individuals, 25 Obj-SCD individuals (with the impairment in memory and language domain), and 28 aMCI individuals were included. Resting-state fMRI and neuropsychological tests were performed. fALFF was used to reflect the local functional activity and compared between groups. Finally, we analyzed the correlation between the fALFF values of significantly changed regions and neuropsychological performance.Results: We found similar functional activity enhancements in some local brain regions in the Obj-SCD and aMCI groups, including the left orbital part of the inferior frontal gyrus and the left median cingulate and paracingulate gyri. However, some changes in local functional activities of the Obj-SCD group showed different patterns from the aMCI group. Compared with healthy control (HC), the Obj-SCD group showed increased local functional activity in the right middle occipital gyrus, decreased local functional activity in the left precuneus and the left inferior temporal gyrus. In the Obj-SCD group, in normal band, the fALFF value of the right middle occipital gyrus was significantly negatively correlated with Mini-Mental State Examination (MMSE) score (r = −0.450, p = 0.024) and Animal Verbal Fluency Test (AFT) score (r = −0.402, p = 0.046); the left inferior temporal gyrus was significantly positively correlated with MMSE score (r = 0.588, p = 0.002). In slow-4 band, the fALFF value of the left precuneus was significantly positively correlated with MMSE score (r = 0.468, p = 0.018) and AFT score (r = 0.600, p = 0.002). In the aMCI group, the fALFF value of the left orbital part of the inferior frontal gyrus was significantly positively correlated with Auditory Verbal Learning Test (AVLT) long delay cued recall score (r = 0.506, p = 0.006).Conclusion: The Obj-SCD group showed a unique changing pattern; the functional changes of different brain regions have a close but different correlation with cognitive impairment, indicating that there may be a complex pathological basis inside. This suggests that Obj-SCD may be a separate stage of cognitive decline before aMCI and is helpful to the study of preclinical cognitive decline.

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Section: Similar Pattern Between the Obj-scd And Amci Groupsmentioning

confidence: 99%

Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline

Cui

Zhang

et al. 2021

Front. Aging Neurosci.

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“…The FM white matter fiber bundle is one of the tracts that connects to the cingulate gyrus and posterior cingulate cortex, which are affected early in patients with Alzheimer's disease. The FM has been shown to be disrupted in early Alzheimer's disease patients MOVEMENT DISORDERS CLINICAL PRACTICE 2020; 7(6): 629-638. doi: 10.1002/mdc3.12956 635 with amnestic mild cognitive impairment, compared to persons with subjective cognitive decline 63 and persons with subjective cognitive decline compared to HCs. 64 The fiber pathways of the posterior thalamic radiation connect the thalamus with the parietal and occipital lobes and typically are associated with motor and sensory information transmission.…”

Section: Wmh Locations Are Associated With the Specific Subtypes Of Pmentioning

confidence: 99%

White Matter Hyperintensities Related to Parkinson's Disease Executive Function

Linortner

McDaniel

Shahid

et al. 2020

Movement Disord Clin Pract

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Background People with Parkinson's disease (PD) can develop multidomain cognitive impairments; however, it is unclear whether different pathologies underlie domain‐specific cognitive dysfunction. Objectives We investigated the contribution of vascular copathology severity and location, as measured by MRI white matter hyperintensities (WMHs), to domain‐specific cognitive impairment in PD. Methods We studied 85 PD (66.6 ± 9.2 years) and 18 control (65.9 ± 6.6) participants. Using the Fazekas scale for rating the severity of WMH, we subdivided PD into 14 PD–WMH+ and 71 PD–WMH–. Participants underwent global, executive, visuospatial, episodic memory, and language testing. We performed nonparametric permutation testing to create WMH probability maps based on PD‐WMH group and cognitive test performance. Results The PD–WMH+ group showed worse global and executive cognitive performance than the PD–WMH– group. On individual tests, the PD–WMH+ group showed worse Montreal Cognitive Assessment (MoCA), Stroop, Symbol Digit Modalities Test (SDMT), and Digit Span scores. WMH probability maps showed that in the PD–WMH+ group, worse Stroop was associated with lesions centered around the corticospinal tract (CST), forceps major, inferior‐fronto‐occipital fasciculus, and superior longitudinal fasciculus; worse SDMT with lesions around the CST, forceps major, and posterior corona radiata; worse Digit Span with lesions around the posterior corona radiata; and worse MoCA with lesions around the CST. Conclusions We found that WMH severity was associated with PD executive dysfunction, including worse attention, working memory, and processing speed. Disruption of key white matter tracts in proximity to vascular lesions could contribute to these specific cognitive impairments. Early treatment of vascular disease might mitigate some executive dysfunction in a subset of patients with PD.

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“…However, the effective period of symptomatic treatment is limited (Patnode et al, 2020). Therefore, the early diagnosis and prognosis of clinical AD-spectrum patients is of great importance as it increases the time window to implement interventions that attenuate or reverse deterioration (Luo et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Brain Structural Network Compensation Is Associated With Cognitive Impairment and Alzheimer’s Disease Pathology

Sheng¹,

Chen²,

Shao³

et al. 2021

Front. Neurosci.

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BackgroundStructural network alterations in Alzheimer’s disease (AD) are related to worse cognitive impairment. The aim of this study was to quantify the alterations in gray matter associated with impaired cognition and their pathological biomarkers in AD-spectrum patients.MethodsWe extracted gray matter networks from 3D-T1 magnetic resonance imaging scans, and a graph theory analysis was used to explore alterations in the network metrics in 34 healthy controls, 70 mild cognitive impairment (MCI) patients, and 40 AD patients. Spearman correlation analysis was computed to investigate the relationships among network properties, neuropsychological performance, and cerebrospinal fluid pathological biomarkers (i.e., Aβ, t-tau, and p-tau) in these subjects.ResultsAD-spectrum individuals demonstrated higher nodal properties and edge properties associated with impaired memory function, and lower amyloid-β or higher tau levels than the controls. Furthermore, these compensations at the brain regional level in AD-spectrum patients were mainly in the medial temporal lobe; however, the compensation at the whole-brain network level gradually extended from the frontal lobe to become widely distributed throughout the cortex with the progression of AD.ConclusionThe findings provide insight into the alterations in the gray matter network related to impaired cognition and pathological biomarkers in the progression of AD. The possibility of compensation was detected in the structural networks in AD-spectrum patients; the compensatory patterns at regional and whole-brain levels were different and the clinical significance was highlighted.

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White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline

Cited by 48 publications

References 46 publications

Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline

Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline

White Matter Hyperintensities Related to Parkinson's Disease Executive Function

Brain Structural Network Compensation Is Associated With Cognitive Impairment and Alzheimer’s Disease Pathology

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