Training distance to failure in young racing quarter horses fed sodium zeolite A

Nielsen, B.D.; Potter, G.D.; Morris, E.L.; Odom, T.W.; Senor, D.M.; Reynolds, JA; Smith, W. B.; Martin, Michael T.; Bird, E.H.

doi:10.1016/s0737-0806(06)81526-1

Cited by 27 publications

(23 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During the last two decades of the twentieth century a variety of in vitro and in vivo studies have been performed on animal models, mostly using laboratory rodents (mice and rats), but also Beagle breed of dogs (25,(44)(45)(46) as well as Quarter breed of horses (42,47) as the most common companion animal species in order to evaluate the effects of orally applied CPL on their health status and performance (Table 1).…”

Section: Companion Animals and Horsesmentioning

confidence: 99%

“…The dietary strategy of using zeolites in animal studies have shown the possibility of zeolite A as a viable source of silicon for dogs and horses (42,43,50) due to its property to breaks down into bioavailable OSA, (H 4 SiO 4 ) in the digestive system (32). Thus, it provides additional source of silicon to the organism resulting in decreased skeleton injury rates and better training performances in young racing horses (47). However, increased bone formation was observed in randomized controlled studies on broodmare horses (51), but not in yearling horses (52).…”

Section: Companion Animals and Horsesmentioning

confidence: 99%

See 1 more Smart Citation

Zeolite clinoptilolite nanoporous feed additive for animals of veterinary importance: potentials and limitations

et al. 2017

View full text Add to dashboard Cite

I n the past two decades many substances of natural or synthetic origin were studied as potential alternatives to antibiotic growth promoters (AGP) and some of them, particularly immunomodulators (IMs) and nutraceuticals (NCs), have shown to be capable of stimulating functions of the immune system and improving general health. At the same time, they were shown to be harmless for animals and the environment. Promising results have been obtained with natural clay minerals, zeolites among which clinoptilolite (CPL) is the best known as zootechnical and biomedical feed ingredient widely reported in scientific literature and used in farm animal nutrition. CPL has a potential to replace AGP due to its unique anti-bacterial properties, safety and efficacy as dietary supplement in food animals unifying potentials of an IM and NC. Currently, there INTRODUCTIONT he phrase "survival of the fittest" as an alternative to "natural selection" has been adopted and published in 1868 by Charles Darwin (1), and nowadays is becoming so true because of the rapid emergence of antibiotic resistant strains of pathogenic microbes of biomedical, particularly veterinary importance. This is a consequence of non-clinical use and misuse of dietary antibiotics for more than sixty years to prevent bacterial infections and to enhance performance in livestock production, mostly in chickens and pigs (2). Namely, the increased sanitary problems in intensive farming of food animals have been overcome thus far by adding sub-therapeutic doses of antibiotic growth promoters (AGP) infeed to enhance production efficiency by increasing growth rate, improv- ing feed utilization and reducing mortality from clinical disease is well documented particularly in swine production systems (3). However, the consumers especially in developed countries are becoming increasingly concerned about drug residues in meat and other animal products (4). In addition, it has been suggested that the continuous use of antibiotics may contribute to a reservoir of drugresistant bacteria (5) which may be capable of transferring their resistance to pathogenic bacteria in both animals and humans (6). As a result, many countries have banned or are banning the inclusion of antibiotics in diets as a routine means of growth promotion. The first experience of an AGP ban in Sweden in 1986 indicated a reduction in growth and an increase in morbidity and mortality rates in weaned pigs, which emphasized the importance of antibiotic use in intensive swine production(7). The total ban of dietary AGP in the EU countries since January 1, 2006 (EU Regulation No. 1831 and the elimination of their use in animal feed and water in the USA effective January 1, 2017 (FDA, CVM 2012, VFD Basics 2017) has had a serious influence on both health and performance of food animals underlining the need to develop alternative dietary and non-dietary strategies to evaluate the potential antimicrobial agents for their replacement (8). According to the World Health Organization, most antibiotics will not ...

show abstract

Section: Companion Animals and Horsesmentioning

confidence: 99%

Section: Companion Animals and Horsesmentioning

confidence: 99%

Zeolite clinoptilolite nanoporous feed additive for animals of veterinary importance: potentials and limitations

et al. 2017

View full text Add to dashboard Cite

show abstract

“…However, on day 60, the SS plasma silicon concentration had declined to concentrations similar to CO, and lower than day 0. The decrease in silicon concentrations in both groups was unexpected, as plasma silicon concentration increases in horses supplemented with SZA [3,4,7,19]. No explanation can be offered for these results.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have investigated the supplementation of SZA to horses [3,4,6,7] and reported an increase in silicon concentration in plasma and milk. However, the level of tissue accumulation of silicon has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Tissue Response to a Supplement High in Aluminum and Silicon

Turner

Nielsen

O′Connor-Robison

et al. 2007

Biol Trace Elem Res

View full text Add to dashboard Cite

The objective was to determine the effects of sodium zeolite A (SZA) on mineral metabolism and tissue mineral composition in calves. Twenty calves were placed on study at 3 days of age and were placed into one of two groups: SS, which received 0.05% BW SZA added to their milk replacer, and CO, which received only milk replacer. Blood samples were taken on days 0, 30, and 60 for mineral analysis. Urine and feces were collected on day 30 for mineral metabolism, and on day 60, the calves were euthanized, and samples were taken from numerous organs for mineral analyses. Aluminum retention was increased in the SS calves (p = 0.001). Silicon concentrations were increased in the aorta, spleen, lung, muscle, and kidney of the SS calves, and aluminum was increased in all SS tissues (p < 0.05). Calcium concentrations were increased in aorta, liver, muscle, and tendon; phosphorus concentrations were increased in aorta, but decreased in plasma; magnesium concentrations were increased in aorta, heart, kidney, liver, and pancreas, but decreased in plasma; and iron concentrations were decreased in kidney and liver (p < 0.05). The accumulation of tissue aluminum and therefore potential adverse consequences may preclude any benefits of using SZA as a dietary supplement.

show abstract

“…Feeding silicon-deficient diets to livestock would be impractical; therefore, studies comparing animals on presumably silicon-adequate diets to animals on siliconsupplemented diets have been conducted. In horses, a study conducted on young racing quarter horses showed that supplemental SZA was associated with decreased skeletalrelated injury rates and increased distances horses were able to train before being injured [10]. A mechanism by which this occurred is unknown.…”

Section: Introductionmentioning

confidence: 99%

Sodium Zeolite A Supplementation and Its Impact on the Skeleton of Dairy Calves

Turner

Nielsen

O′Connor-Robison

et al. 2007

Biol Trace Elem Res

View full text Add to dashboard Cite

Twenty calves were placed on study at 3 days of age and were placed according to birth order into one of two groups: SS, which received 0.05% BW sodium zeolite A (SZA) added to their milk replacer, and CO, which received only milk replacer. Blood samples were taken on days 0, 30, and 60 for osteocalcin (OC) and deoxypyridinoline (DPD) analysis. On day 60, the calves were euthanized, and synovial fluid, articular cartilage, and both fused metacarpals were collected for bone quality analyses such as architecture and mechanical properties, mineral composition, and glycosaminoglycan concentration. There were no differences in OC concentrations because of treatment (p = 0.12), and CO calves had lower DPD concentrations than SS calves (p = 0.01), but the OC-to-DPD ratio was not different between treatments (p = 0.98). No differences in bone architecture or mechanical properties were detected. SZA supplementation increased cortical bone (p = 0.0002) and articular cartilage (p = 0.05) aluminum content. Glycosaminoglycan concentrations were not different in synovial fluid or cartilage. Supplementation of SZA appeared to alter the rate of bone turnover without altering bone strength. Aluminum concentrations in the bone and cartilage increased, which may be a concern, although the long-term consequences of such remain to be determined.

show abstract

Training distance to failure in young racing quarter horses fed sodium zeolite A

Cited by 27 publications

References 8 publications

Zeolite clinoptilolite nanoporous feed additive for animals of veterinary importance: potentials and limitations

Zeolite clinoptilolite nanoporous feed additive for animals of veterinary importance: potentials and limitations

Tissue Response to a Supplement High in Aluminum and Silicon

Sodium Zeolite A Supplementation and Its Impact on the Skeleton of Dairy Calves

Contact Info

Product

Resources

About