Tissue Response to a Supplement High in Aluminum and Silicon

Turner, K. K.; Nielsen, B.D.; O′Connor-Robison, C.I.; Nielsen, Forrest H.; Orth, Michael

doi:10.1007/s12011-007-8039-x

Cited by 13 publications

(4 citation statements)

References 35 publications

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“…Aluminium retention and augmented calcium concentrations in the liver and muscle were detected in all tissues. In addition, there improved phosphorus concentrations in the aorta but diminished concentrations in plasma; there were amplified magnesium concentrations in the aorta, heart, kidney, liver, and pancreas but reduced concentrations in plasma; and there were lessened iron concentrations in the kidney and liver [91].…”

Section: Brief Description Of Zeolite Cytoxicitymentioning

confidence: 96%

Zeolites: Microporous natural mineral carrier in controlled, targeted (nanocarriers) and gene delivery systems

Ambarish,

Shirsand

2024

German J. Pharm. Biomaterials

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Ongoing efforts are to attain suitable controlled and targeted drug delivery systems to release the therapeutic agent by designing novel formulations. Numerous delivery systems are being used now a days that have magnificently exhibited a positive outcome in clinical trials. Because of assorted assembly, zeolites have gained substantial attention in pharmaceuticals controlled and targeted drug delivery systems. Due to its microporous, mesoporous, or microporous structure, zeolites can be used as a carrier for the delivery of numerous therapeutic drugs at a target site in a controlled manner. Further, a judicious choice of zeolite nanocarriers will enhance the efficacy of various therapeutic drugs accompanied by reduced dosing and toxicity. Besides, zeolite nanocarriers/ nanocomposites framework carrying the drug substance directly in the living cells might be a novel approach for gene therapy. The current review represents the 21st-century development of zeolite-based controlled and targeted delivery systems to target a specific site with active substance/moiety to lower or prevent the action of diseases. Besides dealing with the controlled/targeted delivery systems, this review provides an updated view of zeolite cytotoxicity, immunostimulatory activity, updated patents, and ongoing clinical trials for using zeolites in drug delivery systems.

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Section: Brief Description Of Zeolite Cytoxicitymentioning

confidence: 96%

Zeolites: Microporous natural mineral carrier in controlled, targeted (nanocarriers) and gene delivery systems

Ambarish,

Shirsand

2024

German J. Pharm. Biomaterials

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“…The role of silicon in human biology is poorly understood, although the above findings and studies may suggest beneficial influence of silicon on the human organism in some diseases, like osteoporosis, atherosclerosis, progress of diabetes, propagation of neoplastic process as well as occurrence of heart diseases (TURNER et al 2008). Silicon was also found to reduce negative effects of some processes as skin, hair and nails ageing (JUGDAOHSINGH et al 2002).…”

Section: Silicon and Aluminium Toxicitymentioning

confidence: 99%

Silicon in medicine and therapy

Boguszewska-Czubara

Pasternak

2011

J. Elem.

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Trace elements are a very important factor affecting functions of living organisms. Silicon, the third most abundant trace element in the human body, is present in all healthy tissues of people. It is especially strongly associated with connective tissues, as it has been found to participate in bone development, collagen formation and mineralization of bone matrix. Silicon has also been suggested to be involved in mammalian hormonal control and to protect people from heart diseases. An average dietary intake of silicon is about 20-30 mg/person/day, with higher intakes for men than women. Silicic acid or orthosilicic acid are the bioavailable forms of silicon, found mainly in food rich in fibre and whole grains, in vegetables, fruit and in drinking water. Various alcoholic beverages such as beer or wine also contain considerable amounts of silicon. Silicon provided with food is digested in the gastrointestinal tract to silicic acid, which is then absorbed. With blood, it is distributed into various tissues and organs, where it can exerts its action. The highest amounts of silicon are accumulated in the kidneys, liver, bone, skin, spleen, lungs, while free orthosilicic acid, not bounded to proteins, occurs in blood. The amount of silicon in tissues decreases with age. Depleted levels of silicon have also been observed in some pathological states e.g. atherosclerosis. The aim of the paper has been to present the role of dietary silicon in living organisms. Silicon is necessary for the growth and bone calcification and as a biological crosslinking agent of connective-tissue-based membrane structures. This element is considered to have beneficial effects on several human disorders, including osteoporosis, ageing of skin, hair and nails or atherosclerosis. It has also been suggested that silicon and silicic acid may decrease the bioavailability of aluminium by blocking the uptake of the latter by the gastrointestinal tract and impeding its reabsorption in the kidneys, thus protecting an organism against the toxic (especially neurotoxic) action of aluminium. Anticancer, antiatherosclerotic and antidiabetic effects of silicon have also been suggested.

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“…Silicon has a prominent role in hormonal control, prevention of heart disease [11] and osteoporosis, skin, and hair and nail disorders, atherosclerosis, and the removal of heavy and toxic metals from the brain [12,13]. Its anti-cancer, anti-atherosclerotic, and anti-diabetic effects have also been studied [14]. Forms of silicon (including Silicic acid or Orthosilicic acid) are found in foods rich in ber and drinking water [15,16].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Toxicity of Oral Administrated Nano-SiO2: Can Food Additives Increase Apoptosis?

Firouzamandi

Hejazy

Mohammadi

et al. 2023

Biol Trace Elem Res

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Nano silicon dioxide (Nano-SiO 2 ) has a great deal of application in food packaging, as antibacterial food additives, and in drug delivery systems but this nanoparticle, despite its wide range of utilizations, can generate destructive effects on organs such as the liver, lung, and kidney. This study aimed to investigate the toxicological effects of nano-SiO 2 through apoptotic factors. For this purpose, 40 female rats in 4 groups (n = 10) received 300, 600, and 900 mg/kg/day of nano-SiO 2 at 20-30 nm size orally for 20 days.Relative expression of Caspase3, Bcl-2, and BAX genes in kidney and liver evaluated in Real time-PCR.The Results indicated the overexpression of BAX and Caspase3 genes in the liver and kidney in groups receiving 300 and 900 mg/kg/day of nano-SiO 2 . Bcl-2 gene was up-regulated in the liver and kidney at 600 mg/kg/day compared to the control group. Overexpression of the Bcl-2 gene in the kidney in 300 and 900 mg/kg/day recipient groups was observed (p ≤ 0.05). Histopathological examination demonstrated 600 mg/kg/day hyperemia in the kidney and lung. In addition, at 900 mg/kg/d were distinguished scattered necrosis and hyperemia in the liver. The rate of Epithelialization in the lungs increased. Our study revealed that the oral consumption of nano-SiO 2 can cause respiratory toxicity. The nano-SiO 2 at 300 and 900 mg/kg/day can induce more cytotoxicity in the liver and lung after oral exposure. However, cytotoxicity of nano-SiO 2 at 600 mg/kg/day in the kidney and lung was noticed. Hence, The Using of nano-SiO 2 as an additive and food packaging should be more considered due to their deleterious effects.

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Tissue Response to a Supplement High in Aluminum and Silicon

Cited by 13 publications

References 35 publications

Zeolites: Microporous natural mineral carrier in controlled, targeted (nanocarriers) and gene delivery systems

Zeolites: Microporous natural mineral carrier in controlled, targeted (nanocarriers) and gene delivery systems

Silicon in medicine and therapy

In Vivo Toxicity of Oral Administrated Nano-SiO2: Can Food Additives Increase Apoptosis?

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