Traditional uses, phytochemistry, pharmacology, and toxicology of <i>Pterocephalus hookeri</i> (C. B. Clarke) Höeck: a review

Gan, Zhiqiang; Jiang, Juan; Tao, Honglin; Luo, Shiying; Meng, Xianli; Yu, Jia; Zhang, Yi; Tang, Ce

doi:10.1039/d1ra05548h

Cited by 5 publications

(1 citation statement)

References 36 publications

(34 reference statements)

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“…It possesses the functions of detoxifying, eliminating plague, clearing heat, dispelling wind, and relieving arthralgia ( Commission, 2020 ). Moreover, Yishoucao has been proved to have anti-inflammatory, analgesic, anti-rheumatoid arthritis, and neuroprotective activities ( Gan et al, 2021 ).…”

Section: The Commonly Used Ttm Drugs For the Prevention And Treatment...mentioning

confidence: 99%

Traditional Tibetan medicine to fight against COVID-19: Basic theory and therapeutic drugs

et al. 2023

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The Coronavirus Diseases 2019 (COVID-19) has been rapidly spreading globally and has caused severe harm to the health of people and a substantial social burden. In response to this situation, experts around the world have considered various treatments, including the use of traditional medicine. Traditional Tibetan medicine (TTM), one of the traditional medicines in China, has played an important role in the treatment of infectious diseases in history. It has formed a solid theoretical foundation and accumulated rich experience in the treatment of infectious diseases. In this review, we provide a comprehensive introduction to the basic theory, treatment strategies, and commonly used drugs of TTM for the treatment of COVID-19. In addition, the efficacies and potential mechanisms of these TTM drugs against COVID-19 are discussed based on available experimental data. This review may provide important information for the basic research, clinical application and drug development of traditional medicines for the treatment of COVID-19 or other infectious diseases. More pharmacological studies are needed to reveal the therapeutic mechanisms and active ingredients of TTM drugs in the treatment of COVID-19.

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Section: The Commonly Used Ttm Drugs For the Prevention And Treatment...mentioning

confidence: 99%

Traditional Tibetan medicine to fight against COVID-19: Basic theory and therapeutic drugs

et al. 2023

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Bis‐Iridoids from Pterocephalus hookeri and Evaluation of Their Anti‐Inflammatory Activity

Miao

Zhang

et al. 2022

Chemistry & Biodiversity

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Four new secoiridoid‐iridoid heterodimers, pterocenoids E–H (1–4), together with a known analog (5), were separated from the whole plants of Pterocephalus hookeri. Their structures were characterized by detailed spectroscopic analyses and NMR comparison with reported data for known analogs. Pterocenoid E (1) represents the first bis‐iridoid example incorporating a rare trans‐fused monomeric unit, and the C(8) configuration in 5 was corrected to be reversed to the original assignment. Among all the isolates, compound 5 not only showed moderate inhibition against the nitric oxide production (IC50=36.0±4.3 μM) but also dose‐dependently suppressed the secretion of an important pro‐inflammatory cytokine TNF‐α, in lipopolysaccharide‐induced RAW264.7 cells.

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‘Pterocephalodes hookeri-Onosma hookeri’ decoction protects against LPS-induced pulmonary inflammation via inhibiting TLR4/ NF-κB signaling pathway

Wang

Aga

et al. 2024

Journal of Ethnopharmacology

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Traditional uses, phytochemistry, pharmacology, and toxicology of Pterocephalus hookeri (C. B. Clarke) Höeck: a review

Abstract: Pterocephalus hookeri (C. B. Clarke) Höeck has been used in traditional Tibetan medicine for thousands of years. The existing research results of P. hookeri are summarized, and will provide a basis for the further development of new drugs.

Cited by 5 publications

References 36 publications

Traditional Tibetan medicine to fight against COVID-19: Basic theory and therapeutic drugs

Traditional Tibetan medicine to fight against COVID-19: Basic theory and therapeutic drugs

Bis‐Iridoids from Pterocephalus hookeri and Evaluation of Their Anti‐Inflammatory Activity

‘Pterocephalodes hookeri-Onosma hookeri’ decoction protects against LPS-induced pulmonary inflammation via inhibiting TLR4/ NF-κB signaling pathway

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