Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

Chen, Shiyu; Gao, Yue; Sun, Jiayi; Meng, Xianli; Dong, Yafeng; Fan, Linhong; Li, Xiang; Wang, Ping

doi:10.3389/fphar.2020.00497

Cited by 71 publications

(50 citation statements)

References 145 publications

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“…Pharmacological studies have validated the efficacy of many bioactive compounds in traditional Chinese medicines used over thousands of years. [16] Recent published articles confirm the folkloric application of C. cicadae in arresting and treating several ailments. [10,11] CISP is indispensable in cancer chemotherapy, but its off-target behavior affecting vital organs in the body is worrisome to physicians and patients.…”

Section: Discussionmentioning

confidence: 93%

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Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Pei

et al. 2020

Chemistry & Biodiversity

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Cisplatin (CISP) is an efficacious anticancer agent used in chemotherapy, however, the constraint to its clinical utility is the stray organ toxicity including testicular damage linked to oxidative and inflammatory cascades. This study aimed to explore the protective effect of nucleosides-rich extract from Cordyceps cicadae (NRCE) against CISP-induced testicular damage in rats. Rats were subjected to prophylactic oral administration of NRCE (50, 100 and 400 mg/kg body weight/day) for 7 days prior to testicular toxicity induced by CISP (10 mg/kg, ip) and were sacrificed after 72 h post-CISP injection. Cisplatin caused significant deficits in sperm count, viability and motility, testosterone and follicle stimulating hormone (FSH) compared to normal control. It depressed testicular activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), total antioxidant content (TAC), whereas malondialdehyde (MDA) increased remarkably. CISP considerably increased tumor necrosis factor-alpha (TNF-α) and interleukin-one beta (IL-1β) with alterations in testis histology compared to normal control. Interestingly, NRCE pretreatment inhibited the CISP-induced alterations in reproductive indices, restored the antioxidant activities in testes as well as inflammatory mediators and histology comparable to control. Our findings demonstrate that NRCE could prevent CISP testicular damage via inhibition of oxidative stress and proinflammation in rats.

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Section: Discussionmentioning

confidence: 93%

“…Pharmacological studies have validated the efficacy of many bioactive compounds in traditional Chinese medicines used over thousands of years [16] . Recent published articles confirm the folkloric application of C. cicadae in arresting and treating several ailments [10,11] .…”

Section: Discussionmentioning

confidence: 95%

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Pei

et al. 2020

Chemistry & Biodiversity

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“…In order to reduce oxidative damage in cardiovascular tissue, an increasing number of medicinal plants are used as natural antioxidants in the clinic [ 32 ]. Active components with antioxidant activity can be isolated from various medicinal plants [ 33 , 34 ]. Examples include phenols, flavonoids, and polysaccharides from traditional Chinese herbal medicine.…”

Section: Application Of Antioxidant Natural Drugs For Cardiovasculmentioning

confidence: 99%

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Chang

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress (OS) refers to the physiological imbalance between oxidative and antioxidative processes leading to increased oxidation, which then results in the inflammatory infiltration of neutrophils, increased protease secretion, and the production of a large number of oxidative intermediates. Oxidative stress is considered an important factor in the pathogenesis of cardiovascular disease (CVD). At present, active components of Chinese herbal medicines (CHMs) have been widely used for the treatment of CVD, including coronary heart disease and hypertension. Since the discovery of artemisinin for the treatment of malaria by Nobel laureate Youyou Tu, the therapeutic effects of active components of CHM on various diseases have been widely investigated by the medical community. It has been found that various active CHM components can regulate oxidative stress and the circulatory system, including ginsenoside, astragaloside, and resveratrol. This paper reviews advances in the use of active CHM components that modulate oxidative stress, suggesting potential drugs for the treatment of various CVDs.

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“…Traditional Chinese medicine (TCM) has been established for thousands of years in China’s medical system ( Chen et al, 2020b ). It has the characteristics of overall vision, syndrome differentiation, and treatment, and has unique advantages in the prevention, treatment, rehabilitation, and health care of various diseases ( Liang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Effect of Traditional Chinese Medicine on Inflammatory Diseases Caused by Virus, Especially on Those Caused by COVID-19

Cheng

Yao

et al. 2021

Front. Pharmacol.

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Inflammasomes are large multimolecular complexes best recognized because of their ability to control activation of caspase-1, which in turn regulates the maturation of interleukin-18 (IL-18) and interleukin-1 β (IL-1β). IL-1β was originally identified as a pro-inflammatory cytokine, capable of inducing local and systemic inflammation as well as a fever response reaction in response to infection or injury. Excessive production of IL-1β is related to inflammatory and autoimmune diseases. Both coronavirus disease 2019 (COVID-19) and severe acute respiratory syndrome (SARS) are characterized by excessive inflammatory response. For SARS, there is no correlation between viral load and worsening symptoms. However, there is no specific medicine which is available to treat the disease. As an important part of medical practice, TCM showed an obvious therapeutic effect in SARS-CoV-infected patients. In this article, we summarize the current applications of TCM in the treatment of COVID-19 patients. Herein, we also offer an insight into the underlying mechanisms of the therapeutic effects of TCM, as well as introduce new naturally occurring compounds with anti-coronavirus activity, in order to provide a new and potential drug development strategy for the treatment of COVID-19.

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Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

Cited by 71 publications

References 145 publications

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

The Therapeutic Effect of Traditional Chinese Medicine on Inflammatory Diseases Caused by Virus, Especially on Those Caused by COVID-19

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