Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Abstract

Cisplatin (CISP) is an efficacious anticancer agent used in chemotherapy, however, the constraint to its clinical utility is the stray organ toxicity including testicular damage linked to oxidative and inflammatory cascades. This study aimed to explore the protective effect of nucleosides-rich extract from Cordyceps cicadae (NRCE) against CISP-induced testicular damage in rats. Rats were subjected to prophylactic oral administration of NRCE (50, 100 and 400 mg/kg body weight/day) for 7 days prior to testicular toxicity induced by CISP (10 mg/kg, ip) and were sacrificed after 72 h post-CISP injection. Cisplatin caused significant deficits in sperm count, viability and motility, testosterone and follicle stimulating hormone (FSH) compared to normal control. It depressed testicular activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), total antioxidant content (TAC), whereas malondialdehyde (MDA) increased remarkably. CISP considerably increased tumor necrosis factor-alpha (TNF-α) and interleukin-one beta (IL-1β) with alterations in testis histology compared to normal control. Interestingly, NRCE pretreatment inhibited the CISP-induced alterations in reproductive indices, restored the antioxidant activities in testes as well as inflammatory mediators and histology comparable to control. Our findings demonstrate that NRCE could prevent CISP testicular damage via inhibition of oxidative stress and proinflammation in rats.

Antinociceptive, Anti‐Hyperalgesia and Antiallodynic Activities of Polyphenol Rich Extract fromShorea roxburghiiagainst Cyclophosphamide Induced Peripheral Neuropathy

“…Chemotherapeutic drugs have become one of the most frequently used therapeutic option in the management of various types of cancers/tumors and over the years it has become a cornerstone treatment that has proven effective in improving the quality of life as well as the life expectancy of cancer patients [1,2] . However, despite the efficacies of most of these anticancer drugs, their off‐target multiple organ toxicities can eventually lead to progressive structural and functional cellular changes, which are often times irreversible [3,4] . Several complications including hepatorenal toxicity, neuropathy, cardiovascular, testicular/reproductive toxicities have been widely associated with anticancer drug therapy [3,5] .…”

Unravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats

“…The environmental conditions including temperature, relative humidity as well as the light/dark period were in accordance with standard procedures. 5 The rats were acclimatized for a week and were afforded standard rat food and water ad libitum . The procedures used in this experiment were approved by the Animal Ethics Committee of The Second Peoples Hospital of Wuhu (Ethic code: Wuhuey-20201008).…”

“…Unfortunately, most of these agents indiscriminately target both cancer and normal cells, thus posing severe and in extreme cases life-threatening toxicities. 5–7 …”

Broad Efficacy of Scavenging Free Radicals: Cordyceps sp.

“…Studies on oxidative instruments and the investigation of infection transmission on malignant growth anticipation specialist protection for individual degenerative ailments are discussed underneath. Little particle dietary disease counteraction specialists [112,117], for instance, supplement C (ascorbate), supplement E (tocopherol), and carotenoids have made explicit interest as adversaries of malignancy causing specialists and as shields against degenerative sicknesses [118]. Most carotenoids have cell support development, particularly against singlet oxygen, and many, including/ -carotene, can be utilized to supplement A (retinal) [119].…”