Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway

Song, Haixing; Hou, Xian‐Geng; Zeng, Meiyan; Chen, Xiaojuan; Yang, Tao; Xu, Fuping; Peng, Jun; Peng, Qinghua; Cai, Xiong; Yu, Rong

doi:10.1016/j.jep.2020.112979

Cited by 26 publications

(15 citation statements)

References 51 publications

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“…It induces mitochondrial structural and functional damage by impairment of stage three and four of respiration and generation of free radicals that act as signal transduction molecules to amplify inflammatory cytokines and increase neutrophil recruitment, leading to inf lammatory disorders. 14 The present study showed morphological changes, including a significant increase in GU severity (numbers and length) in the ulcerated group following oral administration of indomethacin, these agree with (Song et al, 2020) 15 whose study showed an increase in ulcer severity due to the mentioned mechanisms. Mitochondrial oxidative stress (MOS) consider as important PG-independent pathway of IND induced gastric mucosal injury that leads to an increase in pro-inflammatory reaction in parallel with increase in neutrophil infiltration which is involved in the pathogenesis of gastric mucosal lesion by overproduction of reactive oxidant, thus the inflammation plays a crucial role in the gastric injury pathogenesis.…”

Section: Discussionsupporting

confidence: 91%

The Protective Eff ects Trimetazidine on Indomethacin Induced Gastric Ulcer in Rat Model

Imad¹,

Al-Qadh²

2023

IJDDT

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Introduction: Gastric ulcer (GU) is the most common gastrointestinal tract disorder, representing about 20% of peptic ulcer due to an imbalance between gastric defense mechanisms and aggressive factors, mainly Helicobacter pylori and non-steroidal anti-infl ammatory drugs (NSAIDs). The study aims to evaluate trimetazidine’s protective eff ect on histopathology, GU severity, infl ammatory and oxidative stress markers (TNF- alpha, MPO and MDA) in rate model of indomethacin induced GU. Method: Total 30 healthy male albino rats were divided into fi ve groups each of ten (N=10). Group A: Given indomethacin vehicles (normal saline 0.9% and tween 80) orally via gavage tube and serve as control positive group. Group B: Induced ulcer by Indomethacin 60 mg/kg orally via oral gavage serve as control negative. Group C: Pretreated with trimetazidine 50 mg/ kg orally by gavage tube 1-hour before administering indomethacin 60 mg/kg. At the end of study histological examination, anti-infl ammatory and antioxidant markers were evaluated. Results: TMZ 50 mg/kg pretreated groups show a signifi cant (p 0.01) reduction in GU severity score and histopathology damage score in comparison with the indomethacin ulcerated group. Moreover, pretreated groups TMZ 50 mg/kg showed a signifi cant reduction in infl ammatory markers (TNF-alpha and MPO) and oxidative stress marker (MDA) in comparison with the induction group, similar to the results of the reference drug. Conclusion: TMZ dihydrochloride has similar effi cacy as standard omeprazole drug by a decrease in oxidative stress status manifested by a reduction in lipid peroxidation indicator marker and a reduction in pro-infl ammatory cytokine level and leukocyte recruitment indicator marker and fi nally, macroscopic and microscopic evaluation show a reduction GU severity.

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Section: Discussionsupporting

confidence: 91%

The Protective Eff ects Trimetazidine on Indomethacin Induced Gastric Ulcer in Rat Model

Imad¹,

Al-Qadh²

2023

IJDDT

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“…An imbalance between the mucosal defense and gastro-irritants/aggressive materials leads to gastric mucosal injury. Untreated conditions could lead to peptic ulcers accompanied by symptoms of abdominal pain, vomiting, nausea, loss of weight, poor appetite, and bloating [ 4 ]. Oxidative stress and inflammation are often linked with the progression of gastric mucosal damage at the cellular level.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Zhao

Zhang

et al. 2021

Open Life Sciences

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Gastric mucosal injury is caused by an imbalance between the mucosal defense and gastro-irritants, leading to gastroenteritis. Diosgenin is a steroidal sapogenin found in the wild Yam plant that has been reported with several pharmacological properties. The aim of this study is to explore the gastroprotective role of diosgenin on gastric mucosal damage caused by HCl/ethanol in rats. Male Sprague-Dawley rats were intragastrically administered with diosgenin (20 mg/kg) before HCl/ethanol (0.15 M HCl in 98 % ethanol) administration. Omeprazole was used as a positive control. Diosgenin-attenuated oxidative stress by enhancing (p < 0.05) antioxidant enzymes, reducing lipid peroxidation (MDA), and modulating nitric oxide (NO) levels. Anti-inflammatory effects of diosgenin were observed by a reduction in pro-inflammatory cytokines (p < 0.05), decreased myeloperoxidase (MPO) activities (p < 0.05), and histopathological observation of gastric mucosal damage. Western blot analysis provided evidence on the downregulation of NF-κβ by diosgenin. The findings showed that diosgenin has a significant protective role on gastric injury caused by HCl/ethanol, through its antioxidant, anti-inflammatory role, and suppression of NF-κβ and MPO activities.

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“…It has been extensively documented that NO and PGE2 play important roles in the second mucosal defense system by maintaining gastric mucosal integrity [22]. NO is well known to exert gastroprotective effects and affect gastric mucosal cells by increasing vasodilation and enhancing mucin secretion [12]. NO can also regulate gastric acidity and secretion of PGE2.…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, increasing attention has been focused on traditional Chinese medicine to treat gastric injury. TCM has been widely used in clinics to treat gastrointestinal-related diseases, with modern research demonstrating that Chinese medicine monomers, extracts, and compounds have gastroprotective effects [4,11,12].…”

Section: Introductionmentioning

confidence: 99%

Bruguiera gymnorrhiza (L.) Lam. Fruit Accelerates Healing in Gastric Injury via the Regulation of the NF-κB Pathway

Zhang

Mai

Gao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Context. Bruguiera gymnorrhiza (L.) Lam. (BG), as a major species of mangroves, is also a traditional Chinese medicine, which has received attention for its anti-inflammatory and anticancer effects. However, the protective effect of BG on gastric injury is rarely studied. Objective. The present study aimed at the anti-inflammatory and antioxidant effects of the extract of Bruguiera gymnorrhiza (L.) Lam. fruit (BGF) on the gastric injury. Materials and Methods. The chemical components in the extract of BGF were used in UPLC/Q-Orbitrap analysis. 60 SD rats were randomized into six groups: normal group (MC), ethanol-injured control group (EC), omeprazole group, and three groups with different doses (50, 100, and 200 mg/kg) of BGF. After continuous administration for seven days, the stomachs of rats were taken out to observe the pathological gastric tissue changes; inflammatory factors and oxidative stress markers in the stomach tissues were measured. Western blot (WB) analyses were conducted to explore the mechanism of BGF on gastric tissue and RAW 246.7 cells with excessive inflammation. Results. BGF enhanced gastric mucosal protection by improving the mucosal blood flow of the stomach and significantly decreased inflammatory factors and oxidative stress markers. Moreover, BGF significantly reduced the expression of p-NF-κB p65. Consistently, BGF demonstrated similar effects on LPS-induced RAW 264.7 cells as it did in vivo. Conclusion. BGF could accelerate the healing of gastric injury by exerting antioxidant and anti-inflammatory effects and maintaining mucosal integrity.

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Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway

Cited by 26 publications

References 51 publications

The Protective Eff ects Trimetazidine on Indomethacin Induced Gastric Ulcer in Rat Model

The Protective Eff ects Trimetazidine on Indomethacin Induced Gastric Ulcer in Rat Model

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Bruguiera gymnorrhiza (L.) Lam. Fruit Accelerates Healing in Gastric Injury via the Regulation of the NF-κB Pathway

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