Bruguiera gymnorrhiza (L.) Lam. Fruit Accelerates Healing in Gastric Injury via the Regulation of the NF-κB Pathway

Abstract

Context. Bruguiera gymnorrhiza (L.) Lam. (BG), as a major species of mangroves, is also a traditional Chinese medicine, which has received attention for its anti-inflammatory and anticancer effects. However, the protective effect of BG on gastric injury is rarely studied. Objective. The present study aimed at the anti-inflammatory and antioxidant effects of the extract of Bruguiera gymnorrhiza (L.) Lam. fruit (BGF) on the gastric injury. Materials and Methods. The chemical components in the extract of BGF were used in UPLC/Q-Orbitrap analysis. 60 SD rats were randomized into six groups: normal group (MC), ethanol-injured control group (EC), omeprazole group, and three groups with different doses (50, 100, and 200 mg/kg) of BGF. After continuous administration for seven days, the stomachs of rats were taken out to observe the pathological gastric tissue changes; inflammatory factors and oxidative stress markers in the stomach tissues were measured. Western blot (WB) analyses were conducted to explore the mechanism of BGF on gastric tissue and RAW 246.7 cells with excessive inflammation. Results. BGF enhanced gastric mucosal protection by improving the mucosal blood flow of the stomach and significantly decreased inflammatory factors and oxidative stress markers. Moreover, BGF significantly reduced the expression of p-NF-κB p65. Consistently, BGF demonstrated similar effects on LPS-induced RAW 264.7 cells as it did in vivo. Conclusion. BGF could accelerate the healing of gastric injury by exerting antioxidant and anti-inflammatory effects and maintaining mucosal integrity.

Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review

“…rhynchopetala. These meroterpenoids have been classified as shikimate-meroterpenoids of the tricycloalternarene type (149)(150)(151)(152) and polyketidemeroterpenoids (131)(132)(133)(134)(135)(136)(137)(138)(139)(140)(141)(142)(143)(144)(145)(146)(147)(148), which contain tetraketide moieties derived from 3,5-dimethylors ellinic acid (131-143) and 6-methylsalicylic acid (144), and hexaketide moiety (145)(146)(147)(148), respectively.…”

“…Subsequently, Lin et al [149] observed that aqueous extracts from B. gymnorrhiza fruit also exhibited a protective effect against DSS-induced ulcerative colitis, and the mechanism may be associated with the attenuation of inflammation, activation of the Keap1/Nrf2 signaling pathway, and modulation of the gut microbiota. Furthermore, Zhang et al [150] reported that methanol extracts of B. gymnorrhiza fruits mitigate inflammation in gastric injury by activating the NF-κB pathway, thus conferring gastroprotective effects. Moreover, consumption of B. gymnorrhiza fruits has been shown to ameliorate systemic inflammations in obesity, increase circulating satiety hormones, reduce lipid profiles, elevate short-chain fatty acids levels, and promote weight loss [151].…”

Retracted: POU Class 2 Associating Factor 1 Exerts a Protective Effect on the Respiratory Syncytial Virus‐Induced Acute Bronchiolitis by the NF‐κB Pathway

“…Tis article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”