Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review

Wang, Ziying; Liu, Jia; Zhu, Zhou; Su, Cheng-Fu; Sreenivasmurthy, Sravan Gopalkrishnashetty; Iyaswamy, Ashok; Lu, Jiahong; Chen, Gang; Song, Ju‐Xian; Li, Min

doi:10.1016/j.biopha.2020.110968

Cited by 62 publications

(36 citation statements)

References 162 publications

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“…Many Traditional Chinese medicines can regulate autophagy [ 15 , 35 – 37 ]. For example, Sal B, derived from Salvia miltiorrhiza , inhibits autophagy at the early stage of autophagy by blocking the autophagy flow and affecting the formation of autophagosomes, and it alleviates cell apoptosis during autophagy [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, studies on the regulation of MI/R injury using Traditional Chinese medicine from the perspective of the mitochondria have gradually increased, and it has shown good effects in improving MI/RI [ 13 , 14 ]. More attention has been paid to the mechanism of inflammation and mitochondrial autophagy [ 15 ]. CA is the dried bark of Cinnamomum cassia Presl [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Effect and Mechanism of Cinnamyl Alcohol on Myocardial Ischemia-Reperfusion Injury

Zhang

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the effect of CA on autophagy and its molecular mechanism after myocardial ischemia/reperfusion injury (MI/RI). Methods. The MI/RI model was established by the ligation of the left anterior descending coronary artery with ischemia and reperfusion. In vitro cell models were established using hypoxia/reoxygenation. Western blot was used to determine the expression levels of beclin-1, P62, and LC3 II. The expression levels of IL-1β, IL-6, TNFα, and apoptosis-related genes Bax, Cyt-c, and Bcl-2 were detected by qRT-PCR. Cell activity was detected by CCK-8. Apoptosis was detected by TUNEL staining. Results. Beclin-1, P62, and LC3 II protein expression and LC3 II/LC3 I level were significantly increased after myocardial ischemia-reperfusion injury. Compared with model group, CA downregulated beclin-1, P62, and LC3 II protein expression and LC3 II/LC3 I level in the myocardium. The results of cell-level experiments showed that CA inhibited the autophagy response of the cardiomyocytes induced by hypoxia-reperfusion injury. Mechanism studies showed that CA targeted the inhibition of ATG12. Knocking down ATG12 reduces the production of inflammatory cytokines induced by H/R. The knockdown of ATG12 also reduced apoptosis and injury of the myocardial cells. Conclusion. Myocardial ischemia-reperfusion can enhance autophagy response and promote apoptosis. CA plays a protective role in myocardium by targeting ATG12, thereby inhibiting autophagy and improving myocardial cell apoptosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic Effect and Mechanism of Cinnamyl Alcohol on Myocardial Ischemia-Reperfusion Injury

Zhang

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…In this review, 18 studies involved basically 2 kinds of PD rodent models: chemical-induced and transgenic animal models. Of the chemical-induced models, the 4 commonly used chemicals are as follows: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); rotenone, 6-hydroxydopamine (6-OHDA), and paraquat (Tanner et al, 2011;Wang et al, 2020). We have listed the details of different models refereed to the 18 studies in Table 1.…”

Section: Animal Modelsmentioning

confidence: 99%

Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies

Jiang

Zhang

et al. 2021

Front. Pharmacol.

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Parkinson’s disease (PD) is a common neurodegenerative disease featured by progressive degeneration of nigrostriatal dopaminergic neurons (DA) accompanied with motor function impairment. Accumulating evidence has demonstrated that natural compounds from herbs have potent anti-PD efficacy in PD models. Among those compounds, resveratrol, a polyphenol found in many common plants and fruits, is more effective against PD. Resveratrol has displayed a potent neuroprotective efficacy in several PD animal models. However, there is still no systematic analysis of the quality of methodological design of these studies, nor of their results. In this review, we retrieved and analyzed 18 studies describing the therapeutic effect of resveratrol on PD animal models. There are 5 main kinds of PD rodent models involved in the 18 articles, including chemical-induced (MPTP, rotenone, 6-OHDA, paraquat, and maneb) and transgenic PD models. The neuroprotective mechanisms of resveratrol were mainly concentrated on the antioxidation, anti-inflammation, ameliorating mitochondrial dysfunction, and motor function. We discussed the disadvantages of different PD animal models, and we used meta-analysis approach to evaluate the results of the selected studies and used SYRCLE’s risk of bias tool to evaluate the methodological quality. Our analytical approach minimized the bias of different studies. We have also summarized the pharmacological mechanisms of resveratrol on PD models as reported by the researchers. The results of this study support the notion that resveratrol has significant neuroprotective effects on different PD models quantified using qualitative and quantitative methods. The collective information in our review can guide researchers to further plan their future experiments without any hassle regarding preclinical and clinical studies. In addition, this collective assessment of animal studies can provide a qualitative analysis of different PD animal models, either to guide further testing of these models or to avoid unnecessary duplication in their future research.

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“…Of note, Traditional Chinese Medicine (TCM) has been regarded as new sources of candidate small‐molecule drugs since natural products have highly diverse bioactivities 14,15 . More recently, some studies have been performed to investigate the effect of TCM extracts or compounds on autophagy for cancer therapeutic purposes 16,17 . For example, curcumin is a widely recognized as a TCM inducer of autophagy‐dependent death, which was reported to inhibit gliomas in vitro and in vivo via Akt/mTOR/P70S6K pathway and ERK1/2 pathway 18,19 .…”

Section: Introductionmentioning

confidence: 99%

“… 14 , 15 More recently, some studies have been performed to investigate the effect of TCM extracts or compounds on autophagy for cancer therapeutic purposes. 16 , 17 For example, curcumin is a widely recognized as a TCM inducer of autophagy‐dependent death, which was reported to inhibit gliomas in vitro and in vivo via Akt/mTOR/P70S6K pathway and ERK1/2 pathway. 18 , 19 Additionally, TCM celastrol suppresses the viability of human U251, U87‐MG and C6 glioma cells by modulating ROS/JNK and Akt/mTOR signalling pathways, indicating the potentially therapeutic effect of TCM celastrol on gliomas.…”

Section: Introductionmentioning

confidence: 99%

Identification of autophagic target RAB13 with small‐molecule inhibitor in low‐grade glioma via integrated multi‐omics approaches coupled with virtual screening of traditional Chinese medicine databases

et al. 2021

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Objectives Autophagy, a highly conserved lysosomal degradation process in eukaryotic cells, has been widely reported closely related to the progression of many types of human cancers, including LGG; however, the intricate relationship between autophagy and LGG remains to be clarified. Materials and methods Multi‐omics methods were used to integrate omics data to determine potential autophagy regulators in LGG. The expression of ZFP36L2 and RAB13 in SW1088 cells was experimentally manipulated using cDNAs and small interfering RNAs (siRNA). RT‐qPCR detects RNAi gene knockout and cDNA overexpression efficiency. The expression levels of proteins in SW1088 cells were evaluated using Western blot analysis and immunofluorescence analysis. Homology modelling and molecular docking were used to identify compounds from Multi‐Traditional Chinese Medicine (TCM) Databases. The apoptosis ratios were determined by flow cytometry analysis of Annexin‐V/PI double staining. We detect the number of autophagosomes by GFP‐MRFP‐LC3 plasmid transfection to verify the process of autophagy flow. Results We integrated various omics data from LGG, including EXP, MET and CNA data, with the SNF method and the LASSO algorithm, and identified ZFP36L2 and RAB13 as positive regulators of autophagy, which are closely related to the core autophagy regulators. Both transcription level and protein expression level of the four autophagy regulators, including ULK1, FIP200, ATG16L1 and ATG2B, and LC3 puncta were increased by ZFP36L2 and RAB13 overexpression. In addition, RAB13 participates in autophagy through ATG2B, FIP200, ULK1, ATG16L1 and Beclin‐1. Finally, we screened multi‐TCM databases and identified gallic acid as a novel potential RAB13 inhibitor, which was confirmed to negatively regulate autophagy as well as to induce cell death in SW1088 cells. Conclusion Our study identified the key autophagic regulators ZFP36L2 and Rab13 in LGG progression, and demonstrated that gallic acid is a small molecular inhibitor of RAB13, which negatively regulates autophagy and provides a possible small molecular medicine for the subsequent treatment of LGG.

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Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review

Cited by 62 publications

References 162 publications

Therapeutic Effect and Mechanism of Cinnamyl Alcohol on Myocardial Ischemia-Reperfusion Injury

Therapeutic Effect and Mechanism of Cinnamyl Alcohol on Myocardial Ischemia-Reperfusion Injury

Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies

Identification of autophagic target RAB13 with small‐molecule inhibitor in low‐grade glioma via integrated multi‐omics approaches coupled with virtual screening of traditional Chinese medicine databases

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