Traditional and novel aspects of the metabolic actions of growth hormone

Sperling, Mark A.

doi:10.1016/j.ghir.2015.06.005

Cited by 27 publications

(27 citation statements)

References 19 publications

(31 reference statements)

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“…Furthermore, treatment with GH reduced visceral adiposity and liver fat . All these studies support the anabolic role for GH and IGF‐1, protecting against IR and hepatic steatosis during puberty …”

Section: Paediatric Nafldsupporting

confidence: 62%

“…GH signalling stimulates the hepatic TG secretion via increased VLDL export and enhances FA oxidation . Overall, GH lowers fasting free FAs . GH stimulates the hepatic glucose production, and triggers IR specifically in adipose tissue and muscle, leading to hyperinsulinaemia.…”

Section: Paediatric Nafldmentioning

confidence: 94%

“…At the beginning of puberty, IR is similar in both sexes and gradually rises during puberty . Growth hormone (GH) secretion at night leads to increased IR . To compensate for IR, insulin secretion increases two to threefold during puberty …”

Section: Paediatric Nafldmentioning

confidence: 99%

“…Growth hormone (GH) secretion at night leads to increased IR . To compensate for IR, insulin secretion increases two to threefold during puberty …”

Section: Paediatric Nafldmentioning

confidence: 99%

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A narrative review of factors associated with the development and progression if non‐alcoholic fatty liver disease

et al. 2019

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Summary Background With the obesity pandemic, non‐alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease. NAFLD can progress to non‐alcoholic steatohepatitis (NASH), a potential cause of liver failure. It remains difficult to identify patients at risk for NASH, despite evolving insights in contributing factors, including genetic variance, hormones, adipokines, diet and body‐fat distribution. We aimed to present a broad perspective on these risk factors associated with NAFLD development and progression with a focus on their contribution in different age groups and susceptible high‐risk populations, hereby giving insight in the pathophysiology of NAFLD. Methods Literature was searched for relevant articles on the pathophysiology of NAFLD in different age groups. Results Our review underscores large contributions of diet, with particularly fructose promoting NASH development, and sex hormones, with oestrogens exerting protective effects and androgens negatively influencing NAFLD development. Genetic variation in corresponding pathways might further determine NAFLD progression. Conclusions Changes throughout the transition from childhood to adulthood show that variations in diet, hormone levels and metabolism are related to NAFLD progression. The human body uses different strategies to handle excessive nutrients, but each comes at a price. When corresponding pathways are strained by hormonal or genetic factors, NASH or other symptoms of the metabolic syndrome ensue. Potentially, stratification based on sex, body‐fat distribution, diet, lifestyle, microbiome, adipokines, sex hormones, blood concentrations of liver enzymes, liver histology and genetic pre‐disposition might help to identify patients at increased risk of NASH.

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Section: Paediatric Nafldsupporting

confidence: 62%

Section: Paediatric Nafldmentioning

confidence: 94%

Section: Paediatric Nafldmentioning

confidence: 99%

“…Growth hormone (GH) secretion at night leads to increased IR . To compensate for IR, insulin secretion increases two to threefold during puberty …”

Section: Paediatric Nafldmentioning

confidence: 99%

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A narrative review of factors associated with the development and progression if non‐alcoholic fatty liver disease

et al. 2019

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“…The authors did not discuss potential mechanisms underlying the increase in serum VDBP in acromegaly. A direct effect of GH hypersecretion could be hypothesized, although no similar evidence has been provided so far for hepatic proteins, in general, and hormone carriers in particular [21]. On the other hand, a compensatory effect secondary to above-mentioned changes in vitamin D metabolism induced by GH and IGF-I excess may be hypothesized [18].…”

mentioning

confidence: 96%

Vitamin D-binding protein: one more piece in the puzzle of acromegalic osteopathy?

2016

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In only 5 years, more than 20,000 papers (more than 300 in the last month) dealing with vitamin D have been published, reflecting the deep interest of the scientific community for the role of this hormone in health and disease. There is an agreement that adequate vitamin D status should be defined by concentrations of serum that is the immediate precursor of the active hormone 1,25 dihydroxy-vitamin D3 [7]. However, in some conditions such parameter may not represent a reliable marker of vitamin D activity due to modifications of free hormone levels independently of total hormone storage and amount [8][9][10]. Consistently with the free hormone hypothesis, only hormone not bound to protein vectors can exert biological actions [11]. More than 80 % of circulating vitamin D (i.e., both 25(OH)-vitamin D and 1,25-dihydroxy-vitamin

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Annual banned‐substance review: analytical approaches in human sports drug testing

Thevis

Kuuranne

Walpurgis

et al. 2016

Drug Testing and Analysis

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The aim of improving anti-doping efforts is predicated on several different pillars, including, amongst others, optimized analytical methods. These commonly result from exploiting most recent developments in analytical instrumentation as well as research data on elite athletes' physiology in general, and pharmacology, metabolism, elimination, and downstream effects of prohibited substances and methods of doping, in particular. The need for frequent and adequate adaptations of sports drug testing procedures has been incessant, largely due to the uninterrupted emergence of new chemical entities but also due to the apparent use of established or even obsolete drugs for reasons other than therapeutic means, such as assumed beneficial effects on endurance, strength, and regeneration capacities. Continuing the series of annual banned-substance reviews, literature concerning human sports drug testing published between October 2014 and September 2015 is summarized and reviewed in reference to the content of the 2015 Prohibited List as issued by the World Anti-Doping Agency (WADA), with particular emphasis on analytical approaches and their contribution to enhanced doping controls.

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Traditional and novel aspects of the metabolic actions of growth hormone

Cited by 27 publications

References 19 publications

A narrative review of factors associated with the development and progression if non‐alcoholic fatty liver disease

A narrative review of factors associated with the development and progression if non‐alcoholic fatty liver disease

Vitamin D-binding protein: one more piece in the puzzle of acromegalic osteopathy?

Annual banned‐substance review: analytical approaches in human sports drug testing

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