Vitamin D-binding protein: one more piece in the puzzle of acromegalic osteopathy?

Mazziotti, Gherardo; Maffezzoni, Filippo; Giustina, Andrea

doi:10.1007/s12020-016-0890-0

Cited by 18 publications

(8 citation statements)

References 36 publications

(54 reference statements)

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“…After catabolism, 1-α-hydroxylase and 24-α-hydroxylase act on 25(OH) D to generate 1, 25 dihydroxy vitamin D and 24, 25 dihydroxy vitamin D (20) .Several chronic conditions like nephrotic syndrome, critical illness and end stage liver diseasewhere levels of parathyroid hormone are not raised are recognized by low 25(OH) D levels (21) .Moreover, vitamin D may affect metabolic disease, diabetes, metabolic syndromeand insulin resistance (22) . In our study, concentration of vitamin D was decreased that is in agreement with other studies (12,23) which found that vitamin D deficiencyor gonadal status is not related to the differences in gene expressions in patients with acromegaly.…”

Section: P-value Pearson Correlation Parametersupporting

confidence: 93%

“…In acromegalyincreased bone desorptioncould have important role in calcium balance (9,10) . In acromegaly patients hypo-vitaminosis D reported (11) ; also lower peripheral bio-availability of vitamin D had been showndue to the effect of GHexcess secretion on vitamin D binding protein (12) . Increased bone turnover had been related to active acromegaly disease (13) which causes secondary osteoporosis that lead to elevate fracture risk and even morbidity and mortality (14) .…”

Section: Introductionmentioning

confidence: 99%

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Studying the impact of vitamin D deficiency in Iraqi acromegalic patients and its relation with some biochemical parameters

Abdullah¹,

Mohaisn²,

Nsaif³

et al. 2020

ATMPH

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Acromegaly is described as a less common chronic disease occursas a result ofover secretion of growth hormone (GH) often from a pituitary adenoma; it is connected to noticeable morbidity and increased mortality. Our study aimed to determine calcium (Ca) and vitamin D status inacromegalic patients regarding disease activity and estimating the relationship between vitamin D, IGF-1 and some biochemical parameters. Correlations of vitamin D with IGF-1, BMI, Ca, GOT, GPT, ALP, T3, T4, TSH, urea and creatinine were studied. The study groups comprise of 50 male, 25 acromegalic patients and 25 control male groups. The results of vitamin D measurements showed a decrease levels of vitamin D in all acromegalic patients and this revealed that patients with acromegaly have a high significant decrease (p < 0.001) of BMI, IGF-1, vitamin D, Ca, GOT and creatinine compared to control group, while significant increase for GPT, ALP, T3, T4 and urea for patients with acromegaly. However, the results showed a highly positive significant association between vitamin D and BMI, IGF-1, urea, creatinine and T4 levels, whereas demonstrated a highly significant positivecorrelation of vitamin D levels with GOT and ALP, also the results showed non-significant difference between vitamin D, Ca and T3 with a negative correlation with TSH also asignificant positive correlation between vitamin D and GPT appeared. We concluded that acromegalic patients were suffering from low vitamin D levels compared to the controls group and also suffering from lower kidney activity (hydroxylation at the position of 25-OH-D3 site) and this is evident from the high creatinine levels in the blood, which leads to the non-activation and even low levels of vitamin D and therefore acromemglic patients will suffer from vitamin D deficiency high risk thus the treatment procedures for acromegaly should include doses of active vitamin D, which reduces the risk of this deficiency.

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Section: P-value Pearson Correlation Parametersupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Studying the impact of vitamin D deficiency in Iraqi acromegalic patients and its relation with some biochemical parameters

Abdullah¹,

Mohaisn²,

Nsaif³

et al. 2020

ATMPH

View full text Add to dashboard Cite

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“…Notwithstanding the stimulatory effects of GH and IGF-I on vitamin D activation by the kidney (55), hypovitaminosis D is found in patients with acromegaly consistently (100, 101). There is evidence suggesting lower peripheral bioavailability of vitamin D in acromegaly because of an increase in serum levels of vitamin D-binding protein (102,103). GH excess influences PTH pulsatility with prolongation of pulse duration and increase in pulse mass (104); however, the skeletal implications of these effects are unclear.…”

Section: Effects Of Gh Excess On Calcium and Phosphate Metabolismmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Bone disorders associated with acromegaly: mechanisms and treatment

Mazziotti

Lania

Canalis

2019

European Journal of Endocrinology

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Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert physiological actions on the skeleton throughout life, by stimulating longitudinal bone growth in children, the acquisition of bone mass during adolescence and the maintenance of skeletal architecture in adults. When GH and IGF-I are secreted in excess, bone remodeling is enhanced leading to deterioration of bone microstructure and impairment of bone strength. Indeed, acromegaly causes skeletal fragility, and vertebral fractures are reported in a remarkable number of subjects exposed to GH and IGF-I excess. The management of skeletal fragility in acromegaly is a challenge, since the awareness of this complication is low, the prediction of fracture risk is difficult to ascertain, the risk of fractures remains after the control of acromegaly and the effectiveness of bone-active drugs is unknown. This review is an update on bone disorders associated with acromegaly and provides a perspective of possible therapeutic approaches based on emerging pathophysiological and clinical information.

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“…VD is a negative modulator of renin-angiotensinaldosterone system and through ACE2 downregulation may mitigate clinical manifestations of COVID-19 [58]. Moreover, since vitamin D-binding protein (VDBP) [59] may be involved in ARDS [60] through association with actin, CD44, and annexin A2 [61,62] in the presence of low VD levels in the blood an increased availability of VDBP for complement and neutrophil activation may be observed [63,64].…”

Section: Pathophysiological Evidence Linking Hypovitaminosis D and Comentioning

confidence: 99%

Hypovitaminosis D and the endocrine phenotype of COVID-19

Giustina

2021

Endocrine

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Background Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease. Aim Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19. Conclusions This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status. Keywords Vitamin D • Hypocalcemia • Vertebral fractures • Diabetes mellitus • Obesity • COVID-19

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Vitamin D-binding protein: one more piece in the puzzle of acromegalic osteopathy?

Cited by 18 publications

References 36 publications

Studying the impact of vitamin D deficiency in Iraqi acromegalic patients and its relation with some biochemical parameters

Studying the impact of vitamin D deficiency in Iraqi acromegalic patients and its relation with some biochemical parameters

MANAGEMENT OF ENDOCRINE DISEASE: Bone disorders associated with acromegaly: mechanisms and treatment

Hypovitaminosis D and the endocrine phenotype of COVID-19

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