Studying the impact of vitamin D deficiency in Iraqi acromegalic patients and its relation with some biochemical parameters

Abstract

Acromegaly is described as a less common chronic disease occursas a result ofover secretion of growth hormone (GH) often from a pituitary adenoma; it is connected to noticeable morbidity and increased mortality. Our study aimed to determine calcium (Ca) and vitamin D status inacromegalic patients regarding disease activity and estimating the relationship between vitamin D, IGF-1 and some biochemical parameters. Correlations of vitamin D with IGF-1, BMI, Ca, GOT, GPT, ALP, T3, T4, TSH, urea and creatinine were studied. The study groups comprise of 50 male, 25 acromegalic patients and 25 control male groups. The results of vitamin D measurements showed a decrease levels of vitamin D in all acromegalic patients and this revealed that patients with acromegaly have a high significant decrease (p < 0.001) of BMI, IGF-1, vitamin D, Ca, GOT and creatinine compared to control group, while significant increase for GPT, ALP, T3, T4 and urea for patients with acromegaly. However, the results showed a highly positive significant association between vitamin D and BMI, IGF-1, urea, creatinine and T4 levels, whereas demonstrated a highly significant positivecorrelation of vitamin D levels with GOT and ALP, also the results showed non-significant difference between vitamin D, Ca and T3 with a negative correlation with TSH also asignificant positive correlation between vitamin D and GPT appeared. We concluded that acromegalic patients were suffering from low vitamin D levels compared to the controls group and also suffering from lower kidney activity (hydroxylation at the position of 25-OH-D3 site) and this is evident from the high creatinine levels in the blood, which leads to the non-activation and even low levels of vitamin D and therefore acromemglic patients will suffer from vitamin D deficiency high risk thus the treatment procedures for acromegaly should include doses of active vitamin D, which reduces the risk of this deficiency.

Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with Diabetes

“…This increase was explained by the favorable correlation between body weight and bone mineral density rather than obesity. Abdullah et al [30] observed that BMI was considerably greater in ACRO patients when compared to the control group, which is consistent with our findings. Table 2 illustrates that ARG activity was significantly p˂0.0001 decreased in the ACRO patients 3.45±1.30 compared to control 5.98±2.39.…”

“…It is wealth to mention that the study of Hameed et al [34] was in agreement with our findings. In the same manner, Hameed et al [35] and Abdullah et al [30] found that IGF-I levels in ACRO patients were higher compared to the control, these studies concur with our results. The present investigation found that FSG levels in the patients group were significantly higher than control.…”