Trace Elements in the Wall of Abdominal Aortic Aneurysms With and Without Coexisting Iliac Artery Aneurysms

Ziaja, Damian; Chudek, Jerzy; Sznapka, Mariola; Kita, Andrzej; Biolik, Grzegorz; Sieroń–Stołtny, Karolina; Pawlicki, Krzysztof; Domalik, Jolanta; Ziaja, Krzysztof

doi:10.1007/s12011-015-0240-8

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…Additionally, we found disturbed proportions between Cu and Pb in TAA and Zn and Pb in both types of aneurysm, while concentration of Cd is similar to normal aortas in both types of aneurysm. Other studies have shown that the elevated levels of Cd in the walls of AAA coexisting with iliac artery aneurysms may suggest an impact on the accumulation of this toxic element and greater damage of the iliac artery wall [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?

Socha

Karwowska

Kurianiuk

et al. 2020

Biol Trace Elem Res

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The objective of this study was to estimate the content of copper, zinc, selenium, cadmium, and lead in the tissue of patients with aortic aneurysms. Molar ratio of Cu/Zn and antioxidant micronutrients to toxic elements was also calculated. A total of 108 patients: 47 with abdominal aortic aneurysm (AAA), 61 patients with thoracic aortic aneurysm (TAA), and a control group of 20 abdominal aortic (AA) and 20 thoracic aortic (TA) wall samples from the deceased were studied. The concentrations of mineral components in the tissue samples were determined by the AAS method. The average concentration of Cu in the aortic wall of patients with TAA was significantly lower than in the aortic wall samples of healthy people. The mean concentration of Zn in the aortic wall of patients with AAA and TAA was significantly lower than in the control group samples. Cu/Zn ratio was significantly higher in AAA patients than in control group which indicates a greater role of oxidative stress and inflammatory process in this type of aneurysm. The concentration of Se was significantly decreased in TAA patients compared with the control group; in turn, the concentration of Pb was increased in this group of patients. We observed significantly lower Cu/Pb ratio in TAA patients than in control group, whereas Zn/Pb ratio was significantly lower comparing with control samples in both types of aneurysms. In the examined aneurysms, we have shown the differences in concentrations of mineral components compared with the control tissues. The Zn concentration was decreased in both AAA and TAA samples. Impaired ratio of Zn to Pb may predispose to aortic aneurysms.

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Section: Discussionmentioning

confidence: 99%

“…However, only few studies have been conducted to evaluate the oxidative stress status of AAA patients. Some studies reported imbalance of mineral components in patients with aneurysms [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?

Socha

Karwowska

Kurianiuk

et al. 2020

Biol Trace Elem Res

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“…In this work, an association with a lower content of Ni as well as a significantly higher content of Cd was demonstrated. The levels of remaining trace elements like Cu, Zn, Mn, Mg, and Ca were detected at similar concentrations [ 105 ]. The authors of this study linked the higher Cd concentrations to an increased exposure to tobacco smoke [ 68 , 106 ].…”

Section: The Role Of Trace Elements In Selected Cardiovascular Diseasesmentioning

confidence: 99%

“…However, the variation of the Ni contents in this study were found not to be statistically relevant. This was most likely due to the small size of the study group, as claimed by the authors, since the content of trace elements was assessed in samples of AAA walls harvested intraoperatively in only 19 consecutive patients [ 105 ].…”

Section: The Role Of Trace Elements In Selected Cardiovascular Diseasesmentioning

confidence: 99%

The Role of Trace Elements in Cardiovascular Diseases

Wechselberger,

Messner,

Bernhard

2023

Toxics

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Essential trace elements play an important role in human physiology and are associated with various functions regulating cellular metabolism. Non-essential trace elements, on the other hand, often have well-documented toxicities that are dangerous for the initiation and development of diseases due to their widespread occurrence in the environment and their accumulation in living organisms. Non-essential trace elements are therefore regarded as serious environmental hazards that are harmful to health even in low concentrations. Many representatives of these elements are present as pollutants in our environment, and many people may be exposed to significant amounts of these substances over the course of their lives. Among the most common non-essential trace elements are heavy metals, which are also associated with acute poisoning in humans. When these elements accumulate in the body over years of chronic exposure, they often cause severe health damage in a variety of tissues and organs. In this review article, the role of selected essential and non-essential trace elements and their role in the development of exemplary pathophysiological processes in the cardiovascular system will be examined in more detail.

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Association of Circulating and Aortic Zinc and Copper Levels with Clinical Abdominal Aortic Aneurysm: a Meta-analysis

Chen

Zhang

et al. 2020

Biol Trace Elem Res

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Trace Elements in the Wall of Abdominal Aortic Aneurysms With and Without Coexisting Iliac Artery Aneurysms

Cited by 3 publications

References 22 publications

Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?

Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?

The Role of Trace Elements in Cardiovascular Diseases

Association of Circulating and Aortic Zinc and Copper Levels with Clinical Abdominal Aortic Aneurysm: a Meta-analysis

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