Association of Circulating and Aortic Zinc and Copper Levels with Clinical Abdominal Aortic Aneurysm: a Meta-analysis

Chen, Tingting; Zhang, Hongliang; Zhang, Yang; Yang, Mengqi; Wu, Juntao; Yang, Minjun; Lin, Jun; Gao, Weixu; Tang, Lijiang; Xu, Baohui; Jiang, Jianjun; Chen, Xiaofeng

doi:10.1007/s12011-020-02187-8

Cited by 5 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Edvinsson et al found that Zn levels were decreased in human thoracic aortic dissection tissues and in the plasma of AD patients ( 55 ). Similar results were also detected in patients with AAA and TAA, suggesting that Zn levels in the plasma and aorta might influence the progression of aortic dissection and aneurysms ( 56 , 57 ). Zinc deficiency has been reported to cause increased oxidative stress and autoreactive inflammation, which contribute to many cardiovascular diseases ( 36 ).…”

Section: Discussionsupporting

confidence: 72%

Single-Cell Sequencing of Immune Cells in Human Aortic Dissection Tissue Provides Insights Into Immune Cell Heterogeneity

Liu

Zou

Tang

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundInflammation plays an important role in the progression of sporadic aortic dissection (AD). Immune cells, especially macrophages, infiltrate the aorta and secrete inflammatory cytokines and matrix metalloproteinases to cause degradation of the extracellular matrix, thereby contributing to the pathogenesis of AD. However, the cellular heterogeneity within these immune cells has not been fully characterized.MethodsWe used single-cell RNA sequencing to profile the transcriptomes of all immune cells in AD tissue and normal aorta. Using magnetic-activated cell sorting gating on CD45, we obtained a higher resolution identification of the immune cell subsets in the aorta.ResultsWe observed significant differences in the proportion of major immune cell subpopulations between AD and normal aorta tissues. Macrophages accounted for a higher percentage in the normal aorta, while the proportions of T cells, B cells and natural killer (NK) cells were all increased in AD tissues. Macrophage clusters that expanded in AD tissues originated primarily from circulating monocytes and expressed genes encoding proinflammatory cytokines and molecules involved in tissue repair. T and NK cells in AD tissues exhibited enhanced cytotoxic properties. A cluster of CD4+ T cells that had expanded in AD tissues was Th17-like and might contribute to the pathogenesis of AD. Cell–cell interaction analysis highlighted the increased communication between macrophages and T cells, which primarily regulated the costimulation of T cells.ConclusionsOur study provides a comprehensive characterization of immune cells in the dissected aorta with an emphasis on the role of macrophages and T cells. The information from our study improves our understanding of immune mechanisms in AD formation and helps to identify additional useful targets for early diagnosis or therapy of AD.

show abstract

Section: Discussionsupporting

confidence: 72%

Single-Cell Sequencing of Immune Cells in Human Aortic Dissection Tissue Provides Insights Into Immune Cell Heterogeneity

Liu

Zou

Tang

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Whereas, copper ions can induce a proteotoxic stress response under internal environment disorders and pathological conditions by disturbing the fatty acylated component homeostasis of the Krebs cycle, leading to the aggregation of fatty acylated proteins ( 37 ). Multiple studies have demonstrated that copper metabolism is correlated with the pathogenesis of various cardiovascular diseases, such as atherosclerosis, coronary heart disease, and cardiac hypertrophy ( 38 – 40 ). Multiple studies have confirmed that reactive oxygen species (ROS) play a crucial role in the pathogenesis of AAA ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics

Song

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

BackgroundThe occurrence of abdominal aortic aneurysms (AAAs) is related to the disorder of immune microenvironment. Cuprotosis was reported to influence the immune microenvironment. The objective of this study is to identify cuprotosis-related genes involved in the pathogenesis and progression of AAA.MethodsDifferentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) in mouse were identified following AAA through high-throughput RNA sequencing. The enrichment analyses of pathway were selected through Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG). The validation of cuprotosis-related genes was conducted through immunofluorescence and western blot analyses.ResultsTotally, 27616 lncRNAs and 2189 mRNAs were observed to be differentially expressed (|Fold Change| ≥ 2 and q< 0.05) after AAA, including 10424 up-regulated and 17192 down-regulated lncRNAs, 1904 up-regulated and 285 down-regulated mRNAs. Gene ontology and KEGG pathway analysis showed that the DElncRNAs and DEmRNAs were implicated in many different biological processes and pathways. Furthermore, Cuprotosis-related genes (NLRP3, FDX1) were upregulated in the AAA samples compared with the normal one.ConclusionCuprotosis-related genes (NLRP3,FDX1) involved in AAA immune environment might be critical for providing new insight into identification of potential targets for AAA therapy.

show abstract

Thoracoabdominal aortic aneurysm tissue sample study – das Aachener Modell als Beispiel für ein Forschungskooperationskonzept

et al. 2021

View full text Add to dashboard Cite

Association of Circulating and Aortic Zinc and Copper Levels with Clinical Abdominal Aortic Aneurysm: a Meta-analysis

Cited by 5 publications

References 59 publications

Single-Cell Sequencing of Immune Cells in Human Aortic Dissection Tissue Provides Insights Into Immune Cell Heterogeneity

Single-Cell Sequencing of Immune Cells in Human Aortic Dissection Tissue Provides Insights Into Immune Cell Heterogeneity

Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics

Thoracoabdominal aortic aneurysm tissue sample study – das Aachener Modell als Beispiel für ein Forschungskooperationskonzept

Contact Info

Product

Resources

About