Trace Elements in Meconium from Preterm and Full-Term Infants

Friel, JK; Matthew, Jacqueline; Andrews, Wayne; Skinner, C. T.

doi:10.1159/000242919

Cited by 17 publications

(17 citation statements)

References 10 publications

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“…The hepatic manganese concentration shows no consistent change from 20 GW to full-term, and reportedly is 7-9% higher than in adult livers [28]. As bile is the main route of excretion of manganese and copper, these metals can be demonstrated in meconium [30,31]. In fact, the marked T1-weighted hyperintensity of meconium has been attributed to the presence of these ions [1].…”

Section: Discussionmentioning

confidence: 98%

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Magnetic resonance imaging of the fetal gallbladder and bile

2010

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Section: Discussionmentioning

confidence: 98%

“…Comparing the manganese and copper content of meconium from preterm and term infants, Friel et al [30] reported significantly higher concentrations in term infants.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging of the fetal gallbladder and bile

2010

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“…The recovery of trace elements (Zn, Fe and Cu) spiked in meconium ranged between 94.1% (92.4-96.7%) and 93-101% and the percent variance ranged around 2.6% (2.2-3.1%). [14][15][16] The recovery of heavy metals (Pb and Cd) spiked in meconium ranged between 100% and 102%. The inter-assay-coefficient of variability ranged between 0.34% and 8.9%; the intra-assay coefficient of variability ranged between 0.44% and 8.44%.…”

Section: Meconium Analysismentioning

confidence: 99%

“…Many substances processed by the fetus accumulate in the fetal intestine, thus meconium analysis may also be used to assess levels of fetal exposure to toxic metals and mineral content. [11][12][13][14][15][16][17] It has been suggested that, in dry meconium, concentrations of trace elements higher than 100 μg/g (0.01%) can indicate toxicity. 12 Replacing trace element deficiencies or detoxifying after toxic metal exposure pose significant challenges for the neonatologist in the first few weeks of an infant's life.…”

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confidence: 99%

The Effect of Heavy Metals and Trace Elements in the Meconium on Preterm Delivery of Unknown Etiology

Özsoy¹,

Turker²,

Özdemir³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Prematurity is an important etiologic factor for perinatal mortality and morbidity. In our country, preterm births and complications of prematurity account for 26% of perinatal mortality. There are many maternal, fetal or placental, genetic and environmental etiologic factors that cause prematurity. There have been no studies to show an association between preterm delivery of unknown etiology and exposure to heavy metals and trace elements at toxic levels in meconium. The purpose of this study is to measure the levels of heavy metals (lead, cadmium) and trace elements (zinc, iron, copper) in meconium samples and to understand their associations with preterm delivery of unknown etiology. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The levels of heavy metals and trace elements in the meconiums of 810 term or preterm infants with known and unknown etiology for being preterm were measured with a flame atomic absorption spectrophotometer. R Re es su ul lt ts s: : Lead and cadmium were detected in all meconium samples. Heavy metal and trace element levels in meconium were significantly higher in preterms of unknown and known etiology for being preterm compared to term infants (for all p<0.0001). Lead levels in meconium were significantly higher in preterm of unknown etiology compared to preterm of known etiology in posthoc analysis with Bonferroni corrected Mann Whitney U test. C Co on nc cl lu us si io on n: : These results may suggest that lead levels in meconium samples are higher in preterm newborns especially with unknown etiology compared to term newborns. Therefore, we suggest that preterm delivery of unknown etiology may be decreased by decreasing air pollution. K Ke ey y W Wo or rd ds s: : Cadmium; lead; meconium Ö ÖZ ZE ET T A Am ma aç ç: : Prematürite perinatal mortalite ve morbidite için önemli bir risk faktörüdür. Ülkemizde erken doğumlar ve prematüritenin komplikasyonları perinatal mortalitenin %26'sından sorumludur. Prematüriteye neden olan çok sayıda maternal, fötal veya plasental, genetik ve çevresel etiyolojik faktör vardır. Etiyolojisi bilinmeyen erken doğumla mekonyumdaki toksik düzeylerde ağır metallere ve eser elemetlere maruziyet arasındaki iliskiyi gösteren hiçbir çalısma yoktur. Bu çalısmanın amacı mekonyum örneklerinde ağır metal (kursun, kadmiyum) ve eser element (çinko, demir, bakır) düzeylerini ölçmek ve etiyolojisi bilinmeyen erken doğumla ilişkilerini anlamaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Etiyolojisi bilinen ve bilinmeyen 810 term veya preterm bebeğin mekonyumlarındaki ağır metaller ve eser elementler alevli atomik absorbsiyon spektrofotometresi ile ölçüldü. B Bu ul lg gu ul la ar r: : Tüm mekonyum örneklerinde kursun ve kadmiyum saptandı. Mekonyumdaki ağır metal ve eser element düzeyleri etiyolojisi bilinen ve bilinmeyen pretermlerde term bebeklere göre belirgin olarak yüksekti (tümü için p<0,0001). Tukey testiyle post-hoc analizde sadece mekonyumdaki kursun düzeyleri etiyolojisi bilinmey...

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“…However, which component of meconium can stimulate bacterial growth in AF is not yet known. Instead, many researchers have thought meconium as a mere lump of nutrients to stimulate bacterial growth in AF (9, 12, 13). …”

Section: Introductionmentioning

confidence: 99%

Bacterial Growth in Amniotic Fluid Is Dependent on the Iron-Availability and the Activity of Bacterial Iron-Uptake System

Ahn

Park

et al. 2004

J Korean Med Sci

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In the present study, the relationship among iron-availability, antibacterial activity, role of meconium as an iron source and the activity of bacterial iron-uptake system (IUS) for bacterial growth in amniotic fluid (AF) were investigated. Staphylococcus aureus ATCC 6538 and its streptonigrin-resistant (SR) mutant with defective IUS were used as the test strains. The growth of S. aureus in AF was stimulated dosedependently by addition of meconium. Bacterial growth stimulated by meconium was re-inhibited dose-dependently by addition of iron-chelator, dipyridyl and apotransferrin. Iron concentration was correlated with the meconium content in AF (r2=0.989, p=0.001). High-affinity IUS of S. aureus was expressed only in AF but not in AF with meconium. The growth of SR strain was more retarded than that of the parental strain in the iron-deficient brain heart infusion (ID-BHI), clear AF and AF containing apotransferrin. The retarded growth of both strains in the ID-BHI and AF was recovered by addition of holotransferrin, hemoglobin and FeCl3. Taken together, the antibacterial activity of AF is closely related with low iron-availability. Bacterial growth in AF considerably depends on the activity of bacterial IUS. Meconium acts as one of the exogenous iron-sources and thus can stimulate bacterial growth in AF.

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Trace Elements in Meconium from Preterm and Full-Term Infants

Cited by 17 publications

References 10 publications

Magnetic resonance imaging of the fetal gallbladder and bile

Magnetic resonance imaging of the fetal gallbladder and bile

The Effect of Heavy Metals and Trace Elements in the Meconium on Preterm Delivery of Unknown Etiology

Bacterial Growth in Amniotic Fluid Is Dependent on the Iron-Availability and the Activity of Bacterial Iron-Uptake System

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