Trabecular bone score of postmenopausal women is positively correlated with bone mineral density and negatively correlated with age and body mass index

Torğutalp, Şerife Şeyma; Babayeva, Naila; Kara, Ömer Serkan; Özkan, Ömer Faruk; Dönmez, Gürhan; Korkusuz, Feza

doi:10.1097/gme.0000000000001375

Cited by 17 publications

(18 citation statements)

References 29 publications

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“…Previous investigations have shown that HRT and increased BMI prevent bone loss. ( 10,11,29‐32 ) Our study found similar results. The use of HRT appears to be associated with lower postmenopausal bone loss and the women in the lowest bone loss quartile had the greatest increase in BMI.…”

Section: Discussionsupporting

confidence: 85%

Characteristics of Long-Term Femoral Neck Bone Loss in Postmenopausal Women: A 25-Year Follow-Up

Moilanen

Kopra

Kröger

et al. 2020

Journal of Bone and Mineral Research

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The aim of this study was to monitor long‐term changes in bone mineral density (BMD) after menopause and factors affecting BMD. The study population consisted of a random sample of 3222 women from the Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study, of which 62.1% were postmenopausal at the beginning of the study. This group of women underwent dual‐energy X‐ray absorptiometry (DXA) measurements at the femoral neck every 5 years from baseline (in 1989) up to 25‐year follow‐up. They also responded to risk‐factor questionnaires at 5‐year intervals. During the 25‐year follow‐up, the baseline cohort decreased to 686 women. The women were divided into quartiles based on their baseline BMD. Self‐reported hormone replacement therapy (HRT) and corticosteroid use were divided into ever users and never users. Morbidity was assessed as the total number of self‐reported diseases and BMD‐affecting diseases. The mean 25‐year BMD change was found to be −10.1%, p < 0.001. Higher baseline BMD was associated with higher bone loss rate; the reduction in the highest quartile BMD was 11.1% and in the lowest quartile 7.4% (p = 0.0031). Lower baseline body mass index (BMI) and a greater increase in BMI were found to protect against postmenopausal bone loss (p < 0.001). The lowest bone loss quartile included 15.2% more HRT users than the highest bone loss quartile (p = 0.004). The number of diseases/bone‐affecting diseases, use of vitamin D/calcium supplementation, use of corticosteroids, smoking or alcohol use had no statistical significance for annual bone loss rate. This study presents hitherto the longest (25‐year) BMD follow‐up in postmenopausal women. The linear femoral neck bone loss of 10% was less than previously assumed. A 5‐year BMD change appeared to predict long‐term bone loss in postmenopausal women. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

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Section: Discussionsupporting

confidence: 85%

Characteristics of Long-Term Femoral Neck Bone Loss in Postmenopausal Women: A 25-Year Follow-Up

Moilanen

Kopra

Kröger

et al. 2020

Journal of Bone and Mineral Research

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“…Another issue that should be taken into account when assessing bone microarchitecture in patients treated with GCs is the negative correlation of TBS with BMI. A similar correlation was reported in the small study by Torgutalp et al [20], suggesting that abnormalities of the bone tissue microarchitecture may be present more frequently in patients with higher BMI. Still, BMI was not associated with increased fracture occurrence in our study.…”

Section: Effect Of Glucocorticoids On Bone Microarchitecturesupporting

confidence: 87%

Clinical Utility of Trabecular Bone Score (TBS) in Fracture Risk Assessment of Patients with Rheumatic Diseases Treated with Glucocorticoids

et al. 2021

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Chronic glucocorticoid therapy is associated with osteoporosis and can cause fractures in up to 50% of patients. Increased risk of fractures in patients with glucocorticoid-induced osteoporosis does not result only from the decreased bone mineral density (BMD) but also bone microarchitecture deterioration. Trabecular bone score (TBS) is a method complementary to DXA, providing additional information about trabecular bone structure. The aim of this study was to assess the clinical utility of TBS in fracture risk assessment of patients treated with glucocorticoids. Patients with rheumatic diseases treated with glucocorticoids for at least 3 months were enrolled. All recruited patients underwent DXA with additional TBS assessment. We analyzed the frequency of osteoporosis and osteoporotic fractures and assessed factors that might be associated with the risk of osteoporotic fractures. A total of 64 patients were enrolled. TBS and TBS T-score values were significantly lower in patients with osteoporosis compared to patients without osteoporosis. Low energy fractures occurred in 19 patients. The disturbed bone microarchitecture was found in 30% of patients with fractures without osteoporosis diagnosis based on BMD. In the multivariate analysis, only TBS and age were significantly associated with the occurrence of osteoporotic fractures. TBS reflects the influence of glucocorticoid therapy on bone quality better than DXA measured BMD and provides an added value to DXA in identifying the group of patients particularly prone to fractures.

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“…Increasing age was a predictor of increased risk of fracture, which has been confirmed in previous studies. [35][36][37] The duration of illness in postmenopausal women was one of the predictors of a higher risk of fracture.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Value-Added of the Trabecular Bone Score in Patients with Rheumatoid Arthritis

et al. 2021

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Background: Rheumatoid arthritis (RA) presents with inflammation in the joints and bony tissues around them. The trabecular bone score (TBS) is a relatively new indicator that predicts fracture risk better than bone mineral density (BMD). The aim of the current study was to measure TBSs and BMD of patients with RA referring to Resalat Hospital, Tehran. Methods: In this descriptive cross-sectional study, 129 men and women with RA entered the study through convenient sampling during 2016. TBS and BMD were measured in L1-L4. The relationships between age, sex, body mass index (BMI), duration of disease, and daily corticosteroids dose with TBS and BMD were determined by chi-square test, independent samples t test, Pearson correlation, and linear and logistic regression.

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Trabecular bone score of postmenopausal women is positively correlated with bone mineral density and negatively correlated with age and body mass index

Cited by 17 publications

References 29 publications

Characteristics of Long-Term Femoral Neck Bone Loss in Postmenopausal Women: A 25-Year Follow-Up

Characteristics of Long-Term Femoral Neck Bone Loss in Postmenopausal Women: A 25-Year Follow-Up

Clinical Utility of Trabecular Bone Score (TBS) in Fracture Risk Assessment of Patients with Rheumatic Diseases Treated with Glucocorticoids

Evaluating the Value-Added of the Trabecular Bone Score in Patients with Rheumatoid Arthritis

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