Toxoplasma gondii infection in patients with schizophrenia

bakre, Hawre Mustafa; Hussain, Saeed Khulam; Ali, Sideeq

doi:10.15218/zjms.2015.0006

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Considering the small size of the samples, the seroprevalence of T. gondii is high. These results are in line with other studies conducted by Omer in Sulaymaniyah [16], Bakre in Erbil [17], and AL-Maamuri in Baghdad [18], they reported the following seroprevalence rates (28/45 (62%), 30/93 (32.3%), 114/200 (79.7%), respectively. The study participants were admitted and stayed in government-owned psychiatric hospitals for at least 6 months to 10 years in the hospitals.…”

Section: Association Between Latent Toxoplasmosis and Sociodemographi...supporting

confidence: 92%

Correlation between latent toxoplasmosis and thyroid hormone levels in sera of schizophrenic patients

Mohammed¹,

Mageed²

2022

GSC Biol. Pharm. Sci.

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Latent toxoplasmosis is a prevalent chronic infection caused by a protozoan parasite called Toxoplasma gondii. Recent studies have shown that T. gondii may affect thyroid hormone levels and thus induce behavioral alteration. However, this correlation has been inadequately investigated. Therefore, we aimed to examine the relationship between latent toxoplasmosis and thyroid hormone levels in schizophrenic patients. For this purpose, blood samples and sociodemographic information were collected from 101 schizophrenic patients attending three psychiatric hospitals in Kurdistan region of Iraq. Anti-T. gondii-IgG antibodies and thyroid hormones levels (TSH, T3, T4) were determined in sera of all patients using ELISA technique. Anti-T. gondii-IgG antibodies were detected in sera of 40 (39.6%) out of 101 schizophrenic patients. Logistic regression analysis showed significant association between toxoplasmosis and schizophrenic patients in 50-60 age group (OR=6.177, p=0.05), and un-employed patients (OR=3.562, p=0.05). Data analysis showed non-significant difference in TSH levels between IgG seropositive and IgG seronegative group (p>0.05). On the other hand, T4 levels were significantly higher in the seropositive (10.16 ± 2.61) than seronegative group (7.01 ± 2.01), with highly significant positive correlation between IgG and T4 levels (p= 0.001). Finally, T3 levels were significantly higher in the seropositive (1.91 ± 0.5) than seronegative group (1.12 ± 0.43), with non-significant positive correlation between IgG and T3 levels (p=0.30). Owing to the fact that there was statistically significant increase in thyroid hormone levels in T. gondii seropositive patients, our results suggest that there is a significant association between toxoplasmosis and thyroid hormone levels in schizophrenic patients.

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Section: Association Between Latent Toxoplasmosis and Sociodemographi...supporting

confidence: 92%

Correlation between latent toxoplasmosis and thyroid hormone levels in sera of schizophrenic patients

Mohammed¹,

Mageed²

2022

GSC Biol. Pharm. Sci.

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“…One-way ANOVA and chi-square tests were performed for statistical analyses. The independent t-tests and chi-square tests were performed to determine the association between toxoplasma and reproductive hormones and infertility [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Methods and Patientsmentioning

confidence: 99%

Toxoplasmosis Seropositivity and Male Sex Hormones

RiadhHussien¹

2018

AIBM

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Background: Toxoplasmosis is a cosmopolitan disease with acute and chronic infections, caused by the obligate intracellular protozoan parasite Toxoplasma gondii that can infect a variety of cells in almost all warm-blooded animals including humans. The study aimed to determine the seroprevalence of T. gondii infection among males in Duhok city using ELISA (IgG and IgM).The relationship between toxoplasmosis and reproductive hormones including testosterone, free testosterone, and Follicle Stimulating Hormone (FSH) levels and its association with male sterility were also investigated.

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Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis

Bisetegn

Debash

Ebrahim

et al. 2023

Health Science Reports

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Background and Aim: Toxoplasmosis is the most widespread zoonotic disease that affects one-third of the world's population, and imposes a major public health problem worldwide. This study aimed to assess the prevalence of toxoplasmosis among patients with neuropsychiatric patients.Methods: Electronic databases PubMed, Google Scholar, Web of Science, Research Gate, and Scopus were thoroughly searched from February to March 2022 to identify all relevant studies. The quality of studies was evaluated using the Newcastle−Ottawa quality scale for case-control and cross-sectional studies.Statistical analysis was done using STATA version 12 software. A random effect model was used to compute the global pooled seroprevalence of Toxoplasma gondii infection. Heterogeneity was quantified by using I 2 value. Subgroup analysis was done, and publication bias was assessed using a funnel plot and Egger's test.Result: Of 1250 studies, 49 containing 21,093 participants and conducted in 18 countries were included. The global pooled seroprevalence of T. gondii IgG antibody was 38.27% (95% CI: 32.04−44.9) among neuropsychiatric patients and 25.31% (95% CI: 21.53−29.08) in healthy controls with substantial heterogeneity of 98.3%.The prevalence of T. gondii IgG antibody was higher in males (17.52%) than in females (12.35%) neuropsychiatric patients. The highest pooled prevalence of T. gondii IgG antibody was in Europe (57%) followed by Africa (45.25%) and Asia (43%). Time based analysis showed the highest pooled prevalence of T. gondii IgG antibody in 2012−2016 (41.16%).The global pooled seroprevalence T. gondii IgM antibody among neuropsychiatric patients and healthy controls was 6.78% (95% CI: 4.87−8.69) and 3.13% (95% CI: 2.02−4.24), respectively. Conclusion:The pooled prevalence of chronic and acute T. gondii infection among neuropsychiatric patients was 38.27% and 6.78%, respectively. This showed a high

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Toxoplasma gondii infection in patients with schizophrenia

Cited by 3 publications

References 25 publications

Correlation between latent toxoplasmosis and thyroid hormone levels in sera of schizophrenic patients

Correlation between latent toxoplasmosis and thyroid hormone levels in sera of schizophrenic patients

Toxoplasmosis Seropositivity and Male Sex Hormones

Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta‐analysis

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