Toxoplasmosis Seropositivity and Male Sex Hormones

RiadhHussien, Mustafa

doi:10.19080/aibm.2018.11.555823

Cited by 2 publications

(3 citation statements)

References 50 publications

(50 reference statements)

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“…The pattern of seropositive rates in males for acute and chronic toxoplasmosis in the present study agreed, to some extent, with the study of Hussein et al (11) conducted in Duhok province. Which also reported slightly lower rates for total and chronic seroprevalence (22.98% and 16.35%) and a slightly higher rate (6.25%) for acute seroprevalence of toxoplasmosis.…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, they did not estimate the general epidemiological status and risk factors associated with the prevalence of this disease among males. However, recently Hussien et al (11) studied the relationship between toxoplasmosis and male sex hormones. This study is an attempt to correlate the epidemiology of toxoplasmosis and various demographic factors among males using ELISA technique.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence and some Demographic Factors Associated with Toxoplasma gondii Infection among Male Population in Duhok Province/Iraq

Salih

Mero²,

Eassa

2020

Baghdad Sci.J

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The present study aims to investigate the seroprevalence rate of Toxoplasma gondii infection and its relation to some demographic factors among males in Duhok province/Iraq. A total of 424 random blood samples were collected from the male population of different ages (18-60) years and different social-economic classes. Out of 424 samples examined, 108 (25.47%) were seropositive to the anti- T. gondii antibodies; 88 (20.75%) were found seropositive for IgG, while 20 (4.72%) samples were seropositive for IgM. Regarding occupation, the highest percentage for chronic toxoplasmosis was reported in workers followed by policemen and pensioners at rates of 23.96%, 23.6%, and 23.07%, respectively. The age group 18-30 years showed the highest seropositive rate which was 26.6%; the seropositivity rate decreased with the increase of age. Regarding the blood groups, the highest percentage of IgG was reported in both O+ and B- groups, which were 23.2% and 23.1%, respectively. The higher rate of seropositivity was observed among married males (21.32%) as compared to unmarried males (19.05%) and fertile (22.3%) versus sterile males (12.5%). Concerning IgM antibodies, the highest seropositivity (9.4%) was reported in infertile males. The results of this study showed the importance of demographic factors to the epidemiology of T. gondii in males, which support the role of public health in the control of infectious diseases.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Seroprevalence and some Demographic Factors Associated with Toxoplasma gondii Infection among Male Population in Duhok Province/Iraq

Salih

Mero²,

Eassa

2020

Baghdad Sci.J

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“…It results from the abnormal congenital or acquired embryogenesis of the reproductive organs, various infections, and hereditary or hormonal causes (Heinonen et al, 1983). All these factors work to vary the sex hormones concentrations, thus the incomplete formation of the reproductive organs during fetal development (Hussien et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The role of Toxoplasma gondii in concentration of some sex hormones in infertile individual

Al-Ardi¹

2021

Journal of Medical and Pharmaceutical Sciences

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The main objective: Link the incidence of the Toxoplasma gondii present and manifestations of some sex hormones ‎ at ‎infertile persons.‎ Follicle-stimulating hormone (FSH), 17-β Estradiol (E2), and testosterone are key ‎regulators for the development ‎and progress of germline cells. Also affect many defensive ‎functions to the ‎immune system. Toxoplasma gondii attempts to manipulating these ‎Hormones concentration to their survive. ‎ ‎The study methodology‎‏:‏‎ since October 2018 tell 31th March 2019, 100 samples of the blood of ‎infertile ‎patients have been collected from both sexes from outpatient clinics in ‎different areas of ‎Qadisiyah governorate, Iraq. All there examined with Elisa test to detect IgM and IgG ‎antibodies against T. gondii and to estimate concentration of sex hormones. ‎ Results: ‎ 39 samples (39 %) were positive to T. gondii. IgM positive ‎samples were (6 and ‎‎10) with (12% and 20%) at male and female, Positive IgG samples for male ‎and female were (10 and 13) ‎with (20% and 26%).‎ In male, Testosterone ‎concentrations were increased in infected where were (5.4 and 5) ng/ ml with IgG and IgM ‎test. Also E2 were (33.6 and 35) pg/ ml with IgG and IgM infected men ‎. While FSH concentrations were decreased in (12.1 and 12.3) IU with IgG and ‎IgM. In female, FSH and E2 concentrations were increased in infected female, ‎where were (5.45 and 5.9)IU/ ml and (260 and 250)pg/ ml from both hormones with IgG ‎and IgM test. Testosterone concentration was decreased (0.98)ng/ ml with IgG, ‎but increased (1.35) ng/ ml with IgM in female. ‎ ‎The study has been showed that a significant difference in the concentrations ‎of hormones studied ‎between non-infected and infected samples in ‎the acute case, and did not register a ‎significant difference between ‎chronic infection and non-infection, a significant increase ‎in ‎hormones Testosterone and E2 in male and female while FSH in ‎female only, FSH ‎concentration was lower in male after infection.‎ Conclusion: in light the study results the author see that: Infection with the parasite is associated with significant changes ‎in the ‎concentrations of sex hormones in infertile peoples, therefore ‎it can be said that infection ‎with Toxoplasma gondii is one of the ‎main causes of infertility in both sexes.‎ ‎ ‎Suggestions:‎ ‎Conduct broader studies by examining more people and ‎determine the relationship ‎between infertility and sex hormone ‎concentration with infection by T. gondii in girls and ‎boys before ‎or after puberty.‎

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Toxoplasmosis Seropositivity and Male Sex Hormones

Cited by 2 publications

References 50 publications

Seroprevalence and some Demographic Factors Associated with Toxoplasma gondii Infection among Male Population in Duhok Province/Iraq

Seroprevalence and some Demographic Factors Associated with Toxoplasma gondii Infection among Male Population in Duhok Province/Iraq

The role of Toxoplasma gondii in concentration of some sex hormones in infertile individual

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