Toxicology of Metals

Nordberg, Gunnar F.; Fowler, Bruce A.; Nordberg, Monica

doi:10.1016/b978-0-444-59453-2.00001-9

Cited by 375 publications

(356 citation statements)

References 30 publications

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“…Regarding the toxicokinetics, the evaluation of metal 76 accumulated levels in organisms represents the temporal integration of uptake, 77 transport, transformation, accumulation, half-life periods and excretion. In turn, 78 toxicodynamics is related to the toxic effects of metals at the organ, cellular, and 79 molecular levels (Nordberg et al 2014). To perform a realistic and suitable evaluation 80 of the environmental health status of metal contaminated areas based on measurable 81 biological variables (biomarkers), it seems crucial to address both processes 82 mentioned above.…”

Section: Introduction 57mentioning

confidence: 99%

Propensity to metal accumulation and oxidative stress responses of two benthic species (Cerastoderma edule and Nephtys hombergii): are tolerance processes limiting their responsiveness?

et al. 2016

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CitationPropensity edule. In the light of current findings, the information of C. edule as a bioindicator 47 should be complemented by that provided by another infaunal species under field 48 studies, since tolerance mechanisms to metals can hinder a correct diagnosis of 49 sediment contamination and the system's health. Overall, the present study contributed 50 to improve the lack of fundamental knowledge of two widespread and common 51 estuarine species, providing insights of the metal accumulation profiles under a 52 scenario of chronic contamination. Finally, this work provided useful information that 53 can be applied in the interpretation of future environmental monitoring studies. 54 3

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Section: Introduction 57mentioning

confidence: 99%

Propensity to metal accumulation and oxidative stress responses of two benthic species (Cerastoderma edule and Nephtys hombergii): are tolerance processes limiting their responsiveness?

et al. 2016

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“…The daily recommended range of Co in human is 0.005 mg. [12]. Molybdenum (Mo) is an essential element for humans, and dietary recommendation was estimated at 25 µg/day [15]. Lead (Pb) and Cadmium (Cd) are among the most abundant heavy metals and have toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Capacity and Metal Content of Physalis peruviana L. Fruit Sold in Markets

Eken¹,

Ünlü-Endirlik²,

Baldemir³

et al. 2016

Ann Clin Anal Med

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ÖzetAmaç: Antioksidan aktivite gösteren ve eser elementlerin gerekli miktarları-nı içeren tıbbi gıdaların diyetle alınması, iyi bir sağlıklı yaşam sürdürmek için önemlidir. Çalışmamızda, Kayseri'de marketlerde satılan Altınçilek (Physalis peruviana L.) meyvesinin antioksidan kapasitesinin ve metal içeriğinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: P. peruviana meyvesinin antioksidan kapasitesi, 2,2-difenil-1-pikrilhidrazil (DPPH) serbest radikal süpürme testi ile belirlenmiştir. Meyvenin metanol (MeOH) ekstresinin DPPH serbest radikalini temizleme kapasitesi, referans olarak askorbik asit, gallik asit ve bütillen-dirilmiş hidroksitoluen (BHT) gibi bilinen antioksidanlarla karşılaştırılmıştır. P. peruviana meyvesinin metal içeriği atomik absorpsiyon spektrometresi (AAS) kullanılarak ölçülmüştür. Bulgular: P. peruviana meyve ekstresinin DPPH serbest radikal temizleme aktivitesinin olduğu, fakat antioksidan kapasitesinin standart maddelerden daha düşük olduğu tespit edilmiştir. P. peruviana, askorbik asit, gallik asit ve BHT'nin % 50 inhibitör konsantrasyon (IC 50 ) değer-leri sırası ile 32 mg/ml, 3.8 mg/ml, 3.51 mg/ml ve 1.21 mg/ml olarak belirlenmiştir. AAS ile yapılan analizler sonucu, meyvenin eser element yönünden zengin içeriğe sahip iken ağır metal içeriğinin az miktarda veya hiç olmadı-ğı gözlenmiştir. Tartışma: Bu sonuçlar, P. peruviana meyvesinin doğal kaynaklı potansiyel bir antioksidan ve eser element kaynağı olduğunu göstermektedir. Anahtar Kelimeler Eser Elementler; Physalis; Antioksidan EtkiAbstract Aim: The dietary intake of medicinal food with antioxidant activity and required amounts of trace elements is important to pursue good healthy life. In our study, we aimed to determine the antioxidant capacity and metal content of goldenberry (Physalis peruviana L.) fruit sold in markets in Kayseri. Material and Method: The antioxidant capacity of P. peruviana fruit was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. The DPPH radical scavenger capacity of the methanol extract of fruit was compared with known antioxidants such as ascorbic acid, gallic acid, and butylated hydroxytoluene (BHT) as references. The metal content of P. peruviana fruit was measured by using atomic absorption spectrometer (AAS). Results: The fruit of P. peruviana was found to possess DPPH free radical scavenging activity but the antioxidant capacity was lower than the standard substances. Inhibitory concentration 50% (IC 50 ) values of P. peruviana, ascorbic acid, gallic acid, and BHT were determined as 32 mg/ml, 3.8 mg/ml, 3.51 mg/ ml, and 1.21 mg/ml, respectively. As a result of the analysis by AAS, it was observed that P. peruviana fruit contented plentiful trace elements and the content of heavy metal was small amount or not detected. Discussion: These observations suggest that the fruit of P. peruviana has a potential source of antioxidant and trace elements of natural origin.

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“…In contrast, Pb is non-essential and can be harmful even in low concentrations, and therefore should be avoided in the environment. High concentrations of inorganic Pb in the human body can cause anemia, diarrhea, or can induce coma as well as being carcinogenic, mutagenic, and toxic for reproduction [1,3]. Although there are various methods to treat heavy-metal-bearing wastewater, Fu and Wang [4] rate environmental pollution with heavy metals as one of the most severe issues today.…”

Section: Introductionmentioning

confidence: 99%

“…However, high concentrations of Zn are harmful to health, causing vomiting, sickness, and diarrhea [1]. Zn is also the fourth-most common metal in use.…”

Section: Introductionmentioning

confidence: 99%

Influence of Salinity and Pb on the Precipitation of Zn in a Model System

et al. 2018

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Fly ash from solid waste incineration plants is a source of a significant mass flow of Zn-and Pb-containing waste. Acidic leaching removes most heavy metals from fly ash, but leads to high concentrations of soluble salts in the solution, resulting in a saline solution enriched in heavy metals. Common treatment methods cause voluminous sludge that is mostly disposed of as hazardous waste and hence leads to a loss of Zn and other heavy metals. On a laboratory scale, precipitation experiments with 2000 mg/L Zn were performed to investigate the impact of salinity (0 to >70,000 mg/L Cl, 0 to 5400 mg/L SO 4 ) and Pb concentration (0 to 800 mg/L) on the formation of mineral phases. The removal efficiency of Zn and Pb after alkalization of the solution was studied. Characterization of the precipitates showed that salinity has a significant impact on the phases produced. At a low salt concentration, zincite (ZnO) is formed. With increasing salinity, the higher concentration of chloride and sulfate increases the stability of various Zn sulphate hydroxides. At a medium salinity of 7000 mg/L, bechererite is predominantly formed, whereas a higher salinity leads to the formation of gordaite. Addition of low amounts of Pb enlarges the stability field of zincite to medium saline solutions but causes lower removal efficiency. The lower removal efficiency observed at low salinity increases at a higher salinity. In high saline solutions, high Pb concentrations (800 mg/L) are needed to form laurionite, a Pb-hydroxychloride phase.

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Toxicology of Metals

Cited by 375 publications

References 30 publications

Propensity to metal accumulation and oxidative stress responses of two benthic species (Cerastoderma edule and Nephtys hombergii): are tolerance processes limiting their responsiveness?

Propensity to metal accumulation and oxidative stress responses of two benthic species (Cerastoderma edule and Nephtys hombergii): are tolerance processes limiting their responsiveness?

Antioxidant Capacity and Metal Content of Physalis peruviana L. Fruit Sold in Markets

Influence of Salinity and Pb on the Precipitation of Zn in a Model System

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