Toxicological profile of the Hymenaea courbaril stem bark hydroalcoholic extract using in vitro bioassays and an alternative in vivo Caenorhabditis elegans model

Lobo, Larissa Aline Carneiro; Santos, Philipe dos; Sousa, José da Silva; Picada, Jaqueline Nascimento; Bianchi, S.; Bassani, Valquíria Linck; Silva, Francisco Carlos da; Ethur, Eduardo Miranda; Goettert, Márcia Inês; Pereira, Patrı́cia

doi:10.1080/15287394.2023.2237069

Journal of Toxicology and Environmental Health, Part A

2023

DOI: 10.1080/15287394.2023.2237069

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Toxicological profile of the Hymenaea courbaril stem bark hydroalcoholic extract using in vitro bioassays and an alternative in vivo Caenorhabditis elegans model

Larissa Aline Carneiro Lobo

Philipe dos Santos

José da Silva Sousa

et al.

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2024

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Cited by 2 publications

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Bioactive dry extract production from Hymenaea courbaril L. bark via spouted bed drying

Souza,

Fregonesi,

Oliveira

2024

Can J Chem Eng

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The work aims to develop and optimize a powdered phytopharmaceutical product from the stem bark of Hymenaea courbaril L. (jatobá) by the spouted bed drying. The study commenced with the extraction of bioactive compounds present in the plant raw material by dynamic maceration using ethanol/water 70% (v/v) at a temperature of 50°C for 60 min, for the ratio stem bark: solvent mass of 1:10 (w/w). The extract quality was assessed by quantifying chemical markers via spectrophotometry (total polyphenols and tannins) and through antioxidant activity by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay. The extractive solution was concentrated, added with drying adjuvant, and submitted to spouted bed drying. Product quality was evaluated by moisture content (Xp), water activity (aW), powder diameter, total polyphenols, and tannins content (PT and TT), and antioxidant activity, expressed as the extract concentration needed to reduce 50% of the DDPH radical (IC50). Spouted bed drying performance was evaluated through the drying yield (REC), product accumulation (Ac), and thermal efficiency (η). The optimal processing conditions were: inlet gas temperature, Tgi: 150°C, the ratio of the mass feed flow rate of the concentrated extract to the evaporation capacity of the dryer, Ws/Wmax: 45%, and the drying gas flow rate relative to minimum spouting, Q/Qms: 1.85. Under these conditions, it is predicted to obtain a dried extract with Xp = 4.9% w/w, PT = 26.0% w/w, REC = 77.7% w/w, η = 44.3%, and Ac = 10% w/w, with adequate values of aW, TT, and high antioxidant activity.

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Bioactive dry extract production from Hymenaea courbaril L. bark via spouted bed drying

Souza,

Fregonesi,

Oliveira

2024

Can J Chem Eng

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Toxicological assessment of the Achyrocline satureioides aqueous extract in the Caenorhabditis elegans alternative model

Santos,

Uczay,

Pflüger

et al. 2024

Journal of Toxicology and Environmental Health, Part A

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Toxicological profile of the Hymenaea courbaril stem bark hydroalcoholic extract using in vitro bioassays and an alternative in vivo Caenorhabditis elegans model

Cited by 2 publications

References 76 publications

Bioactive dry extract production from Hymenaea courbaril L. bark via spouted bed drying

Bioactive dry extract production from Hymenaea courbaril L. bark via spouted bed drying

Toxicological assessment of the Achyrocline satureioides aqueous extract in the Caenorhabditis elegans alternative model

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