Toxicological effects of bioactive peptide fractions obtained from Bothrops jararaca snake venom on the structure and function of mouse seminiferous epithelium

Alberto-Silva, Carlos; Franzin, Celline Sampaio; Gilio, Joyce Meire; Bonfim, Rodrigo Simão; Querobino, Samyr Machado

doi:10.1590/1678-9199-jvatitd-2020-0007

Cited by 10 publications

(3 citation statements)

References 49 publications

(59 reference statements)

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“…Normal cell activity must be protected by ceaseless elimination of surplus ROS, and in situations where the antioxidant defence system is overpowered due to a surge in production of free radicals or the endogenous antioxidant capacity is overwhelmed by elevated levels of seminal plasma ROS, the consequence may be detrimental to semen parameters [30], as observed in this study. However, such physiological defects on sperm cells have been reported using a viper venom [12].…”

Section: Discussionmentioning

confidence: 97%

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Echis ocellatus Venom-Induced Reproductive Pathologies in Rat Model; Roles of Oxidative Stress and Pro-Inflammatory Cytokines

Ajisebiola

Alamu

James

et al. 2022

Toxins

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This study reported reproductive pathologies associated with Echis ocellatus venom in animal model. Twenty male Wistar rats with body weight between 180 and 220 g were selected randomly into two groups (n = 10). Rats in group 1 served as the control while rats in group 2 were envenomed with a single intraperitoneal injection of 0.055 mg/kg−1 (LD6.25) of E. ocellatus venom on the first day and a repeated dose on the twenty fifth day. Both control and envenomed rats were monitored for fifty consecutive days. The venom caused a significant (p < 0.05) reduction in sperm motility, count, and volume, with increased sperm anomalies in envenomed rats compared to the control. Likewise, serum concentrations of male reproductive hormones were significantly (p < 0.05) higher in envenomed rats. Increased levels of malondialdehyde were accompanied by a significant (p < 0.05) decrease in reduced glutathione and catalase activity in the epididymis and testis tissues of envenomed rats. The venom enhanced the release of epididymal and testicular tumor necrosis factor-alpha and interleukin1-beta compared to the control. Furthermore, severe pathological defects were noticed in tissues of the testis and epididymis of envenomed rats. This study demonstrated that E. ocellatus venom toxins can induce reproductive dysfunction in male victims of snake envenoming.

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Section: Discussionmentioning

confidence: 97%

“…Venoms of Crotalus durissus ssp. and Daboia russelli have been documented to cause elevated sperm anomalies and atrophy in testis after envenomation respectively [10,11], while Bothrops jararaca venom toxins have been reported to induce inhibition of spermatogenesis [12].…”

Section: Introductionmentioning

confidence: 99%

Echis ocellatus Venom-Induced Reproductive Pathologies in Rat Model; Roles of Oxidative Stress and Pro-Inflammatory Cytokines

Ajisebiola

Alamu

James

et al. 2022

Toxins

View full text Add to dashboard Cite

show abstract

“…(rattlesnake) venom could cause an increase in sperm morphology abnormality [ 15 ]. Also, toxins present in Bothrops jararaca have been reported to inhibit spermatozoa production [ 16 ]. Despite the available information, the impact of N. nigricollis envenoming on male reproductive and neural functions in biological system remain unreported.…”

Section: Introductionmentioning

confidence: 99%