Toxicological assessment of abeere seed (&lt;i&gt;Huntaria umbellata&lt;/i&gt; K. Schum)

In, Ibeh; Idu, MacDonald; ., J.E. Ataman

doi:10.4314/jmbr.v4i1.10667

Cited by 8 publications

(10 citation statements)

References 3 publications

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“…This result may be due to the immune response of the rats to the extract, which led to the mobilization of immune-competent cells. The implication of this finding is that HU could be immunogenic and this finding appears to be in agreement with that previously reported in rabbits (Ibeh et al, 2007). On the other hand, the HU-induced neutropaenia and granulocytopaenia are indicative of its cytotoxic effect on neutrophil and granulocyte lineages.…”

Section: Discussionsupporting

confidence: 81%

Evaluation of the toxicity and reversibility profile of the aqueous seed extract of <i>Hunteria umbellata</i> (K.Schum) Hallier F. in rodents

Adeneye¹,

Adeyemi²,

Agbaje³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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Hunteria umbellata (K. Schum.) Hallier f. (family: Apocynaceae) is reputed for the folkloric management of labour, pain and swellings, stomach ulcers, diabetes, obesity, and anaemia, with no scientific report of its toxicity and reversibility profile. The present study was, therefore, aimed at investigating the in vivo toxicity and reversibility profile of the aqueous seed extract of Hunteria umbellata (HU). The acute oral and intraperitoneal toxicity studies of HU were determined in Swiss albino mice while its 90-day oral toxicity and toxicity reversibility profile on anthropometric, biochemical, haematological and histopathological parameters were also assessed using standard procedures. Results showed that the LD 50 values for the acute oral and intraperitoneal toxicity studies for HU were estimated to be 1000 mg/kg and 459.3 mg/kg, respectively. Visible signs of immediate and delayed toxicities including starry hair coat, respiratory distress, and dyskinesia were observed. For the chronic oral toxicity study, HU administered for 90 days produced significant (p<0.001) reductions in the weight gain pattern and significant (p<0.001) and dose related increases in the relative weights of liver, stomach, spleen, testis, lungs and heart, at the 100 and 500 mg/kg of HU. Chronic HU treatment also produced significant (p<0.05, p<0.001) dose related reductions in the serum levels of fasting blood glucose, bicarbonate, urea and creatinine while causing non-significant (p>0.05) alterations in the serum levels of sodium, potassium, alaninine transaminase, aspartate transaminase, alkaline phosphatase, total and conjugated bilirubin, total protein and albumin. Also, chronic oral treatment with HU produced significant (p<0.05, p<0.01, p<0.001) and dose-related increases in the red cell count, packed cell volume, haemoglobin concentration, platelet count, total leucocyte count and lymphocyte differential while producing significant (p<0.05) reductions in neutrophil and granulocyte differentials. HU also produced histological features of proliferations of the stomach epithelia, lung tissues, splenic white and red pulps, and testicular spermatogenic series. Following 14 days of oral toxicity reversibility test, there was no significant (p>0.05) reversal in the serum levels of the biochemical and haematological parameters investigated, including the HU-induced histological lesions.Overall, results of this study showed that HU has a relatively low oral toxicity profile but its prolonged use, particularly, at high doses should be with great caution.

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Section: Discussionsupporting

confidence: 81%

Evaluation of the toxicity and reversibility profile of the aqueous seed extract of <i>Hunteria umbellata</i> (K.Schum) Hallier F. in rodents

Adeneye¹,

Adeyemi²,

Agbaje³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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“…The antihyperglycaemic and antihyperlipidaemic effects of HU can be attributed to some of its active phytoprinciples. HU has earlier been reported to contain alkaloids, flavonoids, saponins and tannins (Ibeh et al, 2007;Adeneye and Adeyemi, 2009). It is also well documented in the literature that the presence of glycosides, flavonoids, alkaloids, saponins, terpenoids and tannins account for the hypoglycaemic and hypolipidaemic activities of medicinal plants (Loew and Kaszin, 2002).…”

Section: Figmentioning

confidence: 97%

Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes

Adeneye

Adeyemi

2009

Journal of Ethnopharmacology

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“…and Staphylococcus aureus (Ejimadu and Falodun, 2002).In previous studies, we reported the hypoglycaemic effect and elucidated the mechanisms of hypoglycaemic action of 50-200 mg/kg/day of HU in normal and various models of experimental hyperglycaemic rats (Adeneye and Adeyemi, 2009a,b). Also, previous phytochemical studies showed that HU contains a copious amount of tannins, flavonoids, alkaloids, anthraquinone, cardiac glycosides, phlobatinnins and saponins (Ibeh et al, 2007;Adeneye and Adeyemi, 2009a). Some 20 indole alkaloids have also been isolated from Hunteria umbellata, and the pharmacologically active indole alkaloids include eburnamine, eburnamonine, hunteriamine, hunterine, vincamine and corymine (Boone, 2006).…”

Section: Introductionmentioning

confidence: 96%

“…In addition, Hunteria umbellata flowers and fruits all year round (Boone, 2006). Its vernacular names include Demouain (in French) (Boone, 2006) and Abeere (in Yoruba, Southwest Nigeria) (Ibeh et al, 2007;Adeneye and Adeyemi, 2009a).…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia

Adeneye

Adeyemi

Agbaje

2010

Journal of Ethnopharmacology

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Toxicological assessment of abeere seed (<i>Huntaria umbellata</i> K. Schum)

Cited by 8 publications

References 3 publications

Evaluation of the toxicity and reversibility profile of the aqueous seed extract of <i>Hunteria umbellata</i> (K.Schum) Hallier F. in rodents

Evaluation of the toxicity and reversibility profile of the aqueous seed extract of <i>Hunteria umbellata</i> (K.Schum) Hallier F. in rodents

Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes

Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia

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