Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes

Adeneye, Adejuwon Adewale; Adeyemi, Olufunmilayo O.

doi:10.1016/j.jep.2009.08.037

Cited by 42 publications

(25 citation statements)

References 36 publications

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“…The worldwide prevalence of this major non-communicable disease has been projected to increase to approximately 366 million by the year 2030. Considering its increasing prevalence, attendant complications and heavy economic and social burdens, DM is now considered as a public health nightmare (Wild et al, 2004;Adeneye & Adeyemi, 2009). In addition, current anti-diabetic medications usually have adverse side effects, decreased effi cacy over time, ineffectiveness against some long-term diabetic complications and low cost-effectiveness; therefore, the discovery and development of novel drugs for diabetes is rigorously needed (Hsu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Sancheti¹,

Bafna²,

Kim³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The potential role of 80% methanolic extract of Boehmeria nivea (L.) Gaudich., Urticaceae, root in the treatment of diabetes, along with its antihyperlipidemic and antioxidant effects, was studied in streptozotocin-induced diabetic male Wistar rats. Preliminary screening of the extract revealed the presence of polyphenolics and fl avonoids. The animal study was conducted with variable doses of 125, 250 and 500 mg/ kg of extract for 21 days in diabetic rats. A signifi cant effect was observed at a dose of 500 mg/kg, which was comparable to the standard drug, glibenclamide. Administration of the extract at a 500 mg/kg dose resulted in a signifi cant reduction of fasting blood glucose, total cholesterol, triglycerides, blood urea, alanine aminotransferase, aspartate aminotransferase, urine sugar and urine ketone levels in diabetic rats in comparison with the diabetic control group. Additionally, this dose signifi cantly increased body weight, hemoglobin, plasma total protein, high density lipoprotein cholesterol, liver glycogen content, superoxide dismutase, reduced glutathione and catalase levels in diabetic rats at the end of 21 days of treatment. Therefore, dietary supplementation with Boehmeria nivea root extract could be benefi cial for correcting hyperglycemia, hyperlipidemia and enhancing the antioxidant defense system. Keywords

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Section: Introductionmentioning

confidence: 99%

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Sancheti¹,

Bafna²,

Kim³

et al. 2011

Rev. bras. farmacogn.

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“…Although, quantification of these phytocomponents was not done in this study but this could constitute an area of future study. However, previous studies have reported intestinal glucose uptake inhibition as one of the mechanisms by which HU lowers and control blood glucose (Adeneye and Adeyemi, 2009a;2009b). From the results of the qualitative analyses of HU b on TLC coupled with that of in vivo antihyperglycaemic study, it could be deduced that alkaloids are responsible for intestinal glucose uptake inhibition mechanism of HU.…”

Section: Evaluation Of the Antihyperglycaemic Effect Of Hu Fractions mentioning

confidence: 97%

“…: FHI 107687 were done as previously described by Adeneye and Adeyemi (2009a).. The extraction process was done as previously reported by Adeneye and Adeyemi (2009b).…”

Section: Plant Materialsmentioning

confidence: 99%

“…In South-west Nigeria, traditional birth attendants/midwives employ the fresh leaves and pulp of fresh fruits of Hunteria umbellata in the induction and/or augmentation of labour in gravid uterus at term (Falodun et al, 2006). Hot and cold decoctions made from the plant seeds have also been reported to be highly valued in the local treatment of obesity, hypertension, pain and swellings, anaemia and as immune booster (Boone, 2006;Adeneye and Adeyemi, 2009a;2009b).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have reported the antihyperglycaemic (Adeneye and Adeyemi, 2009a;2009b;Igbe et al, 2009), anti-obesity and antihyperlipidaemic (Adeneye et al, 2010) effects of the crude aqueous seed extract of Hunteria umbellata (HU) in rats. In furthering our investigation of the antihyperglycaemic effect of HU, the present study is aimed at separating and investigating the possible antihyperglycaemic effect of the solvent fractions of HU in normal and alloxan-induced hyperglycaemic rats.…”

Section: Introductionmentioning

confidence: 99%

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The novel antihyperglycaemic action of hunteria umbellata seed fractions mediated via intestinal glucose uptake inhibition

Adeneye

Adeyemi²,

Agbaje³

et al. 2010

Planta Med

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The present study evaluated the antihyperglycaemic effect and mechanism of action of fractions of the aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. (HU) in normal and alloxan-induced hyperglycaemic rats. HU was partitioned in chloroform, acetyl acetate and butan-1-ol to give chloroform fraction (HU c ), ethyl acetate fraction (HU e ), butanol fraction (HU b ) and the "residue" (HU m ), respectively. 200 mg/kg of each of these fraction dissolved in 5% Tween 20 in distilled water was investigated for its acute oral hypoglycaemic effects in normal rats over 6 hours while its repeated dose antihyperglycaemic effect was evaluated in alloxan-induced hyperglycaemic rats over 5 days. In addition, 50 mg/kg of the crude alkaloid fraction (HU Af ) extracted from HU was evaluated for its possible antihyperglycaemic activity in alloxaninduced hyperglycaemic rats using oral glucose tolerance test (OGTT) over 6 hours. Using the solvent system, distilled water-butanol-ammonium hydroxide (2:15:1, v/v/v), HU b was chromatographed and stained with Dragendorff's reagent for confirmatory qualitative analysis for alkaloids. Results showed that oral pre-treatment with 200 mg/kg of HU e , HU b and HU m resulted in a significant (p<0.05, p<0.001) time dependent hypoglycaemic effect, with the butan-1-ol fraction HU causing the most significant (p<0.001) hypoglycaemic effect. In the alloxan-induced hyperglycaemic rats, repeated oral treatment with 200 mg/kg of same HU fractions for 5 days resulted in significant (p<0.05) decreases in the fasting blood glucose concentrations with the most significant (p<0.01) antihyperglycaemic effect also recorded for HU b . Similarly, oral pretreatment with 50 mg/kg of HU Af significantly (p<0.05, p<0.01 and p<0.001) attenuated an increase in the post-absorptive glucose concentration at 1 st -6 th h in the alloxan-induced hyperglycaemic OGTT model. In addition, alkaloid was present in most of the separated spots on the TLC plate. In conclusion, results of this study showed that HU contains a relative high amount of alkaloids which could have accounted for the antihyperglycaemic action of HU that was mediated via intestinal glucose uptake inhibition. Key words:Hunteria umbellata aqueous seed extract, Alkaloid fraction, Intestinal glucose uptake inhibition, Normal and alloxan-induced hyperglycaemic rats List of Abbreviations: C 4 H 9 OH = butan-1-ol; dH 2 O = distilled water; HCl = hydrochloric acid; HU = aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f.; HU Af = alkaloid fraction of HU ; HU b = butan-1-ol fraction of HU; HU c = chloroform fraction of HU; HU e = ethyl acetate fraction of HU; HU m = "residue" fraction of HU; Na 2 CO 3 = sodium bicarbonate; NH 4 OH = ammonium hydroxide; R f = retention factor ; TLC = thin layer chromatography; UV = ultraviolet light

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The Disease‐Preventive Potential of Some Popular and Underutilized Seeds

Bhat¹

2011

Functional Foods, Nutraceuticals, and Degenerative Disease Prevention

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Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes

Cited by 42 publications

References 36 publications

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

The novel antihyperglycaemic action of hunteria umbellata seed fractions mediated via intestinal glucose uptake inhibition

The Disease‐Preventive Potential of Some Popular and Underutilized Seeds

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