Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia

Adeneye, Adejuwon Adewale; Adeyemi, Olufunmilayo O.; Agbaje, Esther Oluwatoyin

doi:10.1016/j.jep.2010.05.009

Cited by 90 publications

(59 citation statements)

References 26 publications

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“…The Lee's index and BMI are highly correlated with the percentage of body fat (Adeneye et al, 2010). Also, our results showed that the relative weight of epididymal fat and triglyceride content were significantly increased in rats under fed high-fat diet than the rats under normal diet.…”

Section: Discussionsupporting

confidence: 52%

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

Liu

Han

et al. 2015

FSTR

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AbbreviationsACL, ATP-citrate lyase; ACO, Acyl-CoA oxidase; AdipoR1, adiponectin receptor 1; AdipoR2, adiponectin receptor 2; AMPK, adenosine 5'-monophosphate-actvated protein kinase; ATGL, adipose triglyceride lipase; BMI, body mass index; CPT-I, carnitine palmitoyltransferase-I; FAS, fatty acid synthesis; HCA, hydroxycitric acid; HDL, high-density lipoprotein; HL, hepatic lipase; NEFA, nonesterified fatty acid; TC, total cholesterol; TG, triglycerol. Original paper Garcinia Cambogia Extracts Prevented Fat Accumulation via Adiponectin- AMPK Signaling Pathway in Developing Obesity RatsGuanxing Liu, Ningning Han, Jing Han, Di CHen, Jian Kang and Haitian Ma IntroductionObesity is a public health problem which is fast growing throughout the modern world. It is a serious risk factor for so-called lifestyle-related diseases such as diabetes, cardiovascular disease and hypertension (Jebb and Moore, 1999;Nakamura et al., 1994). In addition to exercise, it is well known that anti-obesity foods and food ingredients could control and reduce body weight. Some herbal products and plant extracts, such as Semen Cassiaem (Junbao et al., 2004), Panax ginseng berry extract (Attele et al., 2002), Singiber officinale Roscoe (Hasegawa, 2001), and Platycodi radix (Han et al., 2000) have been shown to exert anti-obesity effects in rodents with high fat diet induced obesity (Kim et al., 2007).Garcinia cambogia is an edible fruit native to Southeast Asia (Saito et al., 2005). Its dried rind has been used for centuries throughout Southeast Asia as a food preservative, flavoring agent and carminative. Also, Garcinia cambogia extracts has been used as an ingredient of dietary supplements for weight loss.(-)-Hydroxycitric acid (HCA), a primary acid and the major active G. Liu et al. 836 ingredient in the fruit rinds of Garcinia Cambogia (Lewis and Neelakantan, 1965), has been shown to suppress appetite, body weight gain and fat accumulation in both experimental animals and humans (Greenwood et al., 1981;Heymsfield et al., 1998;Ohia, 2002;Rao and Sakariah, 1988;Sullivan et al., 1974;. HCA had been identified as a potent competitive inhibitor of the extra-mitochondrial enzyme adenosine triphosphate-citratelyase (Watson and Lowenstein, 1970), which catalyzes the cleavage of citrate in extra-mitochondrial to oxaloacetate and acetyl-CoA, a building block of fatty acids synthesis (Márquez, 2012). The inhibitory action of HCA induces the reduction of acetyl-CoA content, thus limiting the biosynthesis of fatty acids and cholesterol (Lowenstein, 1971;Sullivan et al., 1974). Also, the reduction of acetyl-CoA content could decrease the concentration of malonyl-CoA, which stimulates carnitine palmitoyltransferase I (CPT-1) activity and fatty acid oxidation (Ishihara et al., 2000;McCarty, 1994;Saha et al., 1999). Although some studies had revealed that HCA may suppress de novo fatty acid biosynthesis and appetite (Kovacs and Westerterp-Plantenga, 2006) and increase energy expenditure (Kim et al., 2008), subsequently reducing fat accumulation and b...

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Section: Discussionsupporting

confidence: 52%

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

Liu

Han

et al. 2015

FSTR

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“…rats fed with high fat diet, both atherogenic and coronary index had increased notably above the reference value (higher than 4 and 2.5 respectively). 28 Administration of EESS in HFD-fed rats caused profound reduction in the atherogenic and coronary indices and thereby strongly confirmed the hypolipidemic effect of EESS.…”

Section: Discussionmentioning

confidence: 57%

Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats

Kaveripakam¹,

Adikay²,

Retnasamy³

2017

JYP

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“…The serum LDL-C and very low-density lipoprotein cholesterol (VLDL-C) levels were calculated by applying Friedwann's equation (Jo et al, 2014). The atherogenic index (AI) and the coronary artery risk index (CRI) were calculated according to the previous reports (Abbott et al, 1988;Adeneye et al, 2010).…”

Section: Measurement Of Health Indices In Serummentioning

confidence: 99%

Cherry Tomato Supplementation Reduces Cardiovascular Risk

Koh

Lim

Hwang

2017

BSL

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Tomatoes are rich in nutrients and have many beneficial advantages on human health. Four cherry tomato supplementation diets (CTSDs) were prepared from the juice and cake of fresh and processed (heat-treated) cherry tomatoes. Rats were fed CTSDs for 28 days and the changes in health indices in the serum were analyzed. CTSDs significantly decreased (P < 0.05) food efficiency ratio compared with the control. CTSD feeding significantly increased (P < 0.05) the high-density lipoprotein cholesterol level compared with the control, which resulted in a significant (P < 0.05) decrease in coronary artery risk index and atherogenic index. Furthermore, CTSD feeding increased serum serotonin level. These results indicate that CTSD shows antihyperlipidemic effect.

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Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia

Cited by 90 publications

References 26 publications

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats

Cherry Tomato Supplementation Reduces Cardiovascular Risk

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