Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats

Kaveripakam, Sai Sruthi; Adikay, Sreedevi; Retnasamy, Gandhimathi

doi:10.5530/jyp.2017.9.46

Cited by 5 publications

(7 citation statements)

References 15 publications

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“…As the reference drug Atorvastatin, which exhibits similar effects with MEMf in this experiment, has been shown to inhibit 3 hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [6], the normalization of the lipid profile by the plant extract may be due to its ability to lower lipogenesis through inhibition of HMG-CoA reductase. Substances from the plant extract may also enhance lipolysis, suppress appetite and reduce lipid absorption [14]. The observed improvement of the lipid profile corroborates the findings of Kaveripakam et al [14] who observed that 40 d administration of Stereospermum suaveolens in HFD rats decreased the serum concentrations of TC, TG, LDL-C and increased HDL-C levels.…”

Section: Discussionsupporting

confidence: 80%

“…Substances from the plant extract may also enhance lipolysis, suppress appetite and reduce lipid absorption [14]. The observed improvement of the lipid profile corroborates the findings of Kaveripakam et al [14] who observed that 40 d administration of Stereospermum suaveolens in HFD rats decreased the serum concentrations of TC, TG, LDL-C and increased HDL-C levels.…”

Section: Discussionsupporting

confidence: 80%

“…The body weight of the obese animals was significantly reduced by MEMf at the dose 50 mg/kg and Atorvastatin (10 mg/kg). Similarly, studies carried out by Athesh and Jothi [27] and Kaveripakam et al [14] revealed a decrease in body and organ weight in HFD-induced obese rats and mice, after administration of Acorus calamus and Stereospermum suaveolens, respectively.…”

Section: Discussionmentioning

confidence: 62%

“…In this study, rats that received only HFD registered a significant increase in serum TC, TG, LDL-C and VLDL-C levels, while HDL-C levels decreased. This may be due to an increase in both de-novo TG and cholesterol synthesis, and intestinal lipid uptake from the fat enriched diet [14]. As the reference drug Atorvastatin, which exhibits similar effects with MEMf in this experiment, has been shown to inhibit 3 hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [6], the normalization of the lipid profile by the plant extract may be due to its ability to lower lipogenesis through inhibition of HMG-CoA reductase.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, more detailed herbal studies are needed on suitable animal models in the search for novel anti-obesity agents. Previous reports showed the anti-obesity activity of some medicinal plants [14]. M. foetida is a medicinal plant, widely distributed in tropical Africa and has been used in folk medicine to control diabetes and hypertension which are the common complications in obesity.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Obesity Effects of the Methanol Extract of Momordica Foetida (Cucurbitaceae) in Male Wistar Rats

Aphrodite

Nkwenti

Soh

et al. 2021

Int J Pharm Pharm Sci

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Objective: This study was designed to evaluate the effect of the methanol extract of M. foetida (MEMf) on high fat diet-induced obese male rats. Results: HFD induced an increase (P<0.05) in the body and liver weights and the relative abdominal fat pad of the animals in the experimental groups as compared to those in the normal diet group. Also, HFD in the experimental groups reduced (P<0.05) superoxide dismutase and catalase activities, glutathione levels and increased lipid peroxidation in the liver, heart and kidney as well as altered lipid profile (increased serum triglycerides, total cholesterol, low-density lipoproteins (LDL-C), very low-density lipoproteins (VLDL-C), decreased high-density lipoproteins (HDL-C), increased atherogenic index and coronary risk index), when compared to the normal diet animals. All altered parameters were subsequently normalized when obese rats received either MEMf (50 or100 mg/kg) or the reference drug Atorvastatin. Conclusion: This study demonstrates the potential of MEMf to normalize hyperlipidemia, oxidative stress and animal visceral organ weights increased by HFD in rats. Thus, M. foetida is an interesting medicinal plant that could be exploited as sources of anti-obesity agents.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anti-Obesity Effects of the Methanol Extract of Momordica Foetida (Cucurbitaceae) in Male Wistar Rats

Aphrodite

Nkwenti

Soh

et al. 2021

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

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Herbal Medicines for the Management of Obesity

Kılıç

2023

Role of Herbal Medicines

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Ethnobotanical Perspective in the Management of Obesity: An Updated Review

Sharma

Choudhary

Kalra

et al. 2023

CTM

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Background: Obesity is increasing very rapidly from the past few decades in various developed countries that affects human health and produces various chronic disorders like diabetes (type 2), fat deposition in the liver, coronary heart disease, and atherosclerosis. Objective: Apart from the genetic and side effect of the drugs, nearly 80-90% of people become obese due to various behavioural factors, high caloric intake, and some physiological factors. Currently 15-20% male adults are overweight and 20-25% females come under the category of obese. Methods: Obesity is calculated by the body mass index and can be determined by the percentage of body fat and total body fat. Orlistat and sibutramine are two anti-obesogenic drugs which are available in the market and are approved by the Food and Drug Administration. However, these drugs possess various side effects and high in cost. Therefore, more attention goes towards the medicinal plants and their isolated compounds which are low in cost and with few or no side effects. Results: In this review, we give the information about the anti-obesogenic effect of various medicinal plant compounds isolated from them, extract dose, and the mechanism of action of in in vivo and invitro activity. During our literature work, we also found some of the plants with effective in vitro and in vivo activity against obesity. Conclusion: Therefore, the government and scientific community and other pharmaceutical companies help to find and work on a various medicinal plants not to determine their bioactive compounds but also for developing effective anti-obesity drugs.

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Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats

Cited by 5 publications

References 15 publications

Anti-Obesity Effects of the Methanol Extract of Momordica Foetida (Cucurbitaceae) in Male Wistar Rats

Anti-Obesity Effects of the Methanol Extract of Momordica Foetida (Cucurbitaceae) in Male Wistar Rats

Herbal Medicines for the Management of Obesity

Ethnobotanical Perspective in the Management of Obesity: An Updated Review

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