Toxicological and chemical insights into representative source and drinking water in eastern China

An efficient resin for solid-phase extraction and determination by UPLCMS/MS of 44 pharmaceutical personal care products in environmental waters

“…Most of the compounds had a concentration of less than 3 ng/L, whereas that of sulfamethoxazole reached 16.9 ng/L. These findings support previous papers (Shi et al, 2018;Yang et al, 2017;Yu and Cao, 2016;Xu et al, 2018) that reported the presence of these analytes in the same kind of samples.…”

“…The surface water samples were collected from 10 large waterworks, and the results are shown in Table 2. The concentration of the detected analytes ranged from 0.5 to 178.8 ng/L (samples Y-1), which were comparable to those found in samples from the same river (Shi et al, 2018;Yang et al, 2017;Yu and Cao, 2016;Xu et al, 2018).…”

Application ofin vitrobioassays for water quality monitoring in three drinking water treatment plants using different treatment processes including biological treatment, nanofiltration and ozonation coupled with disinfection

“…8 The estrogenic activity in the source water in the current study is higher than previously measured in the US (0.044 to 0.47 ngE2/L), 13 though much lower than detected in source water in China (8.00 to 129 ngE2/L). 7 The detected effect was also similar to effects measured in Australian surface waters from urban and agricultural areas (0.1 to 1.18 ng/L) using the ERα GeneBLAzer assay. 25 Despite the detected estrogenic effects in the source waters, the treatment processes in all three WTPs reduced the estrogenic activity to below the limit of detection in all samples, except for the final water from Neuilly-sur-Marne in December, which had an EC10 of 110 REF.…”

“…This is relevant for drinking water where chemicals are often present at low concentrations, potentially below analytical detection limits, but the mixture effects of the many chemicals present at trace levels may still be significant. 6 Several studies have applied bioassays indicative of induction of xenobiotic metabolism, 7 receptormediated effects, 8,9 adaptive stress responses 10,11 and reactive modes of action 12 to assess drinking water quality, though estrogenic activity is the most commonly studied endpoint. Most studies reported decreased estrogenic activity after drinking water treatment, with either no or low estrogenic activity in treated water, 8,13 though Rosenmai et al 14 found no change in estrogenic activity in one water treatment plant (WTP).…”

Risk‐based approach in the revised European Union drinking water legislation: Opportunities for bioanalytical tools

“…This study demonstrated that the most responsive toxicity pathways were related to xenobiotic metabolism, modulation of hormone systems, reactivity, and adaptive stress responses. Although endocrine effects in this study were mainly induced by (treated) wastewater and storm water (residential run off), other studies demonstrated hormone system–related responses induced by drinking water (Conley et al ; Van Zijl et al ; Shi et al ). Both endocrine disruption and DNA reactivity may underlie carcinogenesis and be related to reproduction and developmental effects, health effects with considerable impact on quality of life (GBD 2016 DALYs and HALE Collaborators ).…”