Toxicokinetic modeling of captan fungicide and its tetrahydrophthalimide biomarker of exposure in humans

Heredia-Ortiz, Roberto; Bouchard, Michèle

doi:10.1016/j.toxlet.2011.09.023

Cited by 11 publications

(4 citation statements)

References 10 publications

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“…In addition, similar to the TAT pathway mutants, 8004Δbc1 also showed a great defect in tolerating the PCA homologues, including phenazine, 1-OH-phenazine, and pyocyanin (Figure ). In contrast, 8004Δbc1 exhibited equal tolerance to kanamycin and captan, of which the antimicrobial mechanisms were not directly related to the respiration chain. , These results verified our previous speculation of the CCM system, TAT pathway, and cytochrome bc1 complex, and confirmed the critical role of the cytochrome bc1 complex in impacting phenazine tolerance in Xcc .…”

Section: Discussionsupporting

confidence: 87%

“…In contrast, 8004Δbc1 exhibited equal tolerance to kanamycin and captan, of which the antimicrobial mechanisms were not directly related to the respiration chain. 49,50 These results verified our previous speculation of the CCM system, TAT pathway, and cytochrome bc1 complex, 21 and confirmed the critical role of the cytochrome bc1 complex in impacting phenazine tolerance in Xcc. Subsequently, results suggested that the role of the cytochrome bc1 complex in tolerating phenazines in Xanthomonas was conserved.…”

Section: Discussionsupporting

confidence: 86%

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Cytochrome bc1 Complex: Potential Breach to Improve the Activity of Phenazines on Xanthomonas

Teng

Mao

et al. 2022

J. Agric. Food Chem.

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The effects of the natural pesticides, phenazines, were reported to be limited by some tolerant metabolism processes within Xanthomonas. Our previous studies suggested that the functional cytochrome bc1 complex, the indispensable component of the respiration chain, might participate in tolerating phenazines in Xanthomonas. In this study, the cytochrome bc1 mutants of Xanthomonas campestris pv. campestris (Xcc) and Xanthomonas oryzae pv. oryzae (Xoo), which exhibit different tolerance abilities to phenazines, were constructed, and the cytochrome bc1 complex was proven to partake a critical and conserved role in tolerating phenazines in Xanthomonas. In addition, results of the cytochrome c mutants suggested the different functions of the various cytochrome c proteins in Xanthomonas and that the electron channeled by the cytochrome bc1 complex to cytochrome C4 is the key to reveal the tolerance mechanism. In conclusion, the study of the cytochrome bc1 complex provides a potential strategy to improve the activity of phenazines against Xanthomonas.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 86%

Cytochrome bc1 Complex: Potential Breach to Improve the Activity of Phenazines on Xanthomonas

Teng

Mao

et al. 2022

J. Agric. Food Chem.

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“…Therefore the results of the present study could be worrying because could suggest sufficiently high exposure to induce detectable urinary levels of the parent compound. On the other hand, THPI, which was usually considered as biomarker for the monitoring of captan exposure (Berthet et al, 2012;Heredia-Ortiz and Bouchard, 2012) was detected in 23.5 % of the urine samples with levels up to 4.13 μg/l, similarly to levels reported in UK adults and children living near orchards (Galea et al, 2015).…”

Section: Children's Exposure Assessment Through Internal Dosementioning

confidence: 52%

Assessment of children’s exposure to currently used pesticides in wallonia, Belgium

et al. 2020

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In spring 2016, a study was carried out to characterize currently used pesticide (CUP) exposure among children living in Wallonia (Belgium). Pesticides were measured in both first morning urine voids of 258 children aged from 9 to 12 years and in ambient air collected close to the children's schools. Out of the 46 pesticides measured in the air, 19 were detected with frequencies varying between 11 % and 100 %, and mean levels ranging from < 0.04 to 2.37 ng/m³. Only 3 parent pesticides were found in 1-10% of the urine samples, while all the metabolites analyzed were positively detected at least once. The captan metabolite (THPI) was quantified in 23.5 % of the samples, while 3,5,6-trichloro-2-pyridinol (chlopryrifos metabolite) was detected in all urines with levels ranging from 0.36-38.96 μg/l. 3-phenoxybenzoic acid (3-PBA), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (t-DCCA) and diethylphosphate were the most abundant pyrethroid metabolites and dialkylphosphate measured. The air inhalation was demonstrated to be a minor route of exposure for the selected CUPs. Statistical regressions highlighted predictors of exposure for some pesticides such like consumption of grey bread, presence of carpets at home or indoor use of pesticides, although no clear source was identified for most of them.

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“…An approach that can help the interpretation of biological data is to develop toxicokinetic models for the pyrethroids of interest and their exposure biomarkers in the body as done for other pesticides [22], [23], [24], [25], [26]. These toxicokinetic models can then be used to reconstruct the daily rates of absorption corresponding to the observed biomonitoring data [27].…”

Section: Introductionmentioning

confidence: 99%

A Novel Toxicokinetic Modeling of Cypermethrin and Permethrin and Their Metabolites in Humans for Dose Reconstruction from Biomarker Data

et al. 2014

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To assess exposure to pyrethroids in the general population, one of most widely used method nowadays consists of measuring urinary metabolites. Unfortunately, interpretation of data is limited by the unspecified relation between dose and levels in biological tissues and excreta. The objective of this study was to develop a common multi-compartment toxicokinetic model to predict the time courses of two mainly used pyrethroid pesticides, permethrin and cypermethrin, and their metabolites (cis-DCCA, trans-DCCA and 3-PBA) in the human body and in accessible biological matrices following different exposure scenarios. Toxicokinetics was described mathematically by systems of differential equations to yield the time courses of these pyrethroids and their metabolites in the different compartments. Unknown transfer rate values between compartments were determined from best fits to available human data on the urinary excretion time courses of metabolites following an oral and dermal exposure to cypermethrin in volunteers. Since values for these coefficients have not yet been determined, a mathematical routine was programmed in MathCad to establish the possible range of values on the basis of physiological and mathematical considerations. The best combination of parameter values was then selected using a statistic measure (reliability factor) along with a statistically acceptable range of values for each parameter. With this approach, simulations provided a close approximation to published time course data. This model allows to predict urinary time courses of trans-DCCA, cis-DCCA and 3-PBA, whatever the exposure route. It can also serve to reconstruct absorbed doses of permethrin or cypermethrin in the population using measured biomarker data.

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Toxicokinetic modeling of captan fungicide and its tetrahydrophthalimide biomarker of exposure in humans

Cited by 11 publications

References 10 publications

Cytochrome bc1 Complex: Potential Breach to Improve the Activity of Phenazines on Xanthomonas

Cytochrome bc1 Complex: Potential Breach to Improve the Activity of Phenazines on Xanthomonas

Assessment of children’s exposure to currently used pesticides in wallonia, Belgium

A Novel Toxicokinetic Modeling of Cypermethrin and Permethrin and Their Metabolites in Humans for Dose Reconstruction from Biomarker Data

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