Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Ashafa, Anofi Omotayo Tom; Orekoya, Latifat Olubukola; Yakubu, Musa Toyin

doi:10.1016/s2221-1691(12)60234-2

Cited by 86 publications

(49 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown that mild perturbation of hepatic tissues integrity did not profoundly affect the capacity of the liver to biosynthesize plasma proteins. 58,100 The present study showed that serum total protein and albumin concentrations of Group 3 were lower than those of Group 1 and Group 2 (Figure 3), which confirmed compromised hepatic function. However, the administration of raw and hydrothermal processed herbs caused limited improvement in the capacity of hepatocytes of fibrotic rats to biosynthesize plasma proteins.…”

Section: Discussionsupporting

confidence: 49%

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Ojiako¹,

Chikezie²,

Ukairo³

et al. 2017

View full text Add to dashboard Cite

Background and Aim: Herbal remedies offer another strategy for alleviation of co-existing liver and kidney pathologic conditions. Objective: The present study ascertained the functional integrity of hepatic and renal tissues, concurrently with blood lipid patterns, of Wistar rats infused with CCl 4 and treated with raw and hydrothermal processed herbs, namely, Monodora myristica, Chromolaena odorata, Buccholzia coriacea and Sphenostylis stenocarpa. Materials and Methods: Measurement of phytochemical contents of the herbs was according to standard methods. The rats were randomly designated on the basis of diets and treatments received for 28 consecutive days. Fibrosis was induced in the Wistar rats by single dose intra-peritoneal injection of CCl 4 for 2 consecutive days. Liver and kidney function tests and serum lipid profile were measured using spectrophotometric methods. Renal and hepatic tissues were subjected to histopathological examinations. Results: The concentrations of alkaloids in the four herbal extracts were within the range of 4.83 ± 0.03 -31.33 ± 0.29 mg/100 g sample, whereas the concentrations of saponins varied within a relatively narrow range: 0.33 ± 0.09 -4.33 ± 0.02 mg/100 g dry sample; p > 0.05. The activity ratios of AST to ALT of the rat groups were generally less than 1.0 unit. Atherogenic indices of fibrotic rats were within the following ranges: TAG/HDL-C ratio (3.59 ± 0.03 -6.76 ± 0.06), TC/HDL-C ratio (3.72 ± 0.02 -6.94 ± 0.05) and LDL-C/HDL-C ratio (2.00 ± 0.01 -4.59 ± 0.02). Conclusion: Losses in phytochemical contents following hydrothermal processing of the herbs did not substantially affect their overall therapeutic scores against morphological and functional impairments of hepatic and renal tissues following CCl 4 intoxication of the rats.

show abstract

Section: Discussionsupporting

confidence: 49%

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Ojiako¹,

Chikezie²,

Ukairo³

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Such toxicity testing is relevant to risk analysis as changes in the hematological system have higher predictive value for human toxicity, when data are translated from animal studies [35]. It can also be used to justify blood relating functions of plant extract [36]. The present study has revealed that there was no vital difference in Hb, red blood cell, white blood cell, erythrocyte sedimentation rate and PVC in the U. longissima treated groups compared with control.…”

Section: Discussionmentioning

confidence: 54%

Hematological, antioxidant and protective performance of Usnea longissima on chemical induced hepatotoxicity in experimental animals

Verma¹,

Paswan²,

Raj³

et al. 2017

JCLM

View full text Add to dashboard Cite

“…Both the control and the treated groups showed a progressive increase in body weight and organs over the duration of the experiment. The increase in body weight could be attributed to the nutritive components in their feed and plant extract [14].…”

Section: Discussionmentioning

confidence: 99%

Acute and Sub-acute Toxicity Profile of Aqueous Leaf Extract of <i>Nymphaea lotus</i> Linn (Nymphaeaceae) in Wistar Rats

Sharaibi¹,

Ogundipe²,

Magbagbeola³

et al. 2015

Trop. J. Pharm Res

View full text Add to dashboard Cite

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Cited by 86 publications

References 38 publications

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Hematological, antioxidant and protective performance of Usnea longissima on chemical induced hepatotoxicity in experimental animals

Acute and Sub-acute Toxicity Profile of Aqueous Leaf Extract of <i>Nymphaea lotus</i> Linn (Nymphaeaceae) in Wistar Rats

Contact Info

Product

Resources

About