Hematological, antioxidant and protective performance of Usnea longissima on chemical induced hepatotoxicity in experimental animals

Verma, Pritt; Paswan, Shravan Kumar; Raj, Abhisek; Nath, Virendra; Gupta, Ramesh K.; Verma, Subhash; Srivastava, Sajal; Rao, Chandana Venketshwara

doi:10.12980/jclm.5.2017j6-250

Cited by 3 publications

(4 citation statements)

References 31 publications

(25 reference statements)

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“…A similar finding was reported post paracetamol administration in mice and treated with M. sapientum [39]. It was reported that M. sapientum has effective antimutagenic activities because of its content of flavonoids and coumarins that could result in the antitoxic effect [40]. This study showed that Cd intoxication in mice led to overexpression in proinflammatory genes expression (TGF-β1, NFκ-β, and COX-1) in the liver and kidney tissues.…”

Section: Discussionsupporting

confidence: 86%

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

et al. 2022

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Heavy metals intoxication causes several health problems that necessitate finding new protective and therapeutic approaches. This study aimed to evaluate the impact of Musa sp. leaves extract (MLE) on hepato-renal toxicities induced by cadmium (Cd) in male mice. The phytochemical screening, metal chelating activity (MCA), and the median lethal dose (LD50) of MLE were determined. Fifty CD-1 male mice were used and intraperitoneally (i.p.) injected with MLE (1000 to 5000 mg/kg b.wt) for MLE LD50 determination. Another 50 mice were used for evaluating the effect of MLE on Cd toxicity. Blood samples were collected for hematological, liver, and kidney functions assessments. Liver tissue homogenates were used for determination of oxidant/antioxidant parameters. Liver and kidney tissues were harvested for histopathological and molecular investigations. MLE showed potent in vitro antioxidant activities. The MCA and LD50 of the MLE were 75 µg/mL and 3000 mg/kg b.wt, respectively. MLE showed beneficial therapeutic activity against hepato-renal toxicities in Cd-intoxicated mice, evidenced by improving the hematological, biochemical, histopathological, and molecular alterations.

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Section: Discussionsupporting

confidence: 86%

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

et al. 2022

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“…IC 50 value of DPPH assay for ascorbic acid and U. longissima extract was found as 340.33 ± 33 µg/ml and 2.63 ± 0.06 µg/ml, respectively. Verma et al (2017) found higher DPPH scavenging activity than standard (ascorbic acid). In the present study, DPPH radical scavenging activity of ethanolic extract of U. longissima was 37.86% at 5 mg/ml concentration and the extract exhibited weak activity when compared with standard antioxidant.…”

Section: Resultsmentioning

confidence: 81%

“…Higher activity in ethanol extract of U. longissima was observed in the present study. Verma et al (2017) also revealed DPPH scavenging activity of ethanol extract of U. longissima lichen. IC 50 value of DPPH assay for ascorbic acid and U. longissima extract was found as 340.33 ± 33 µg/ml and 2.63 ± 0.06 µg/ml, respectively.…”

Section: Resultsmentioning

confidence: 85%

Antioxidant, anti-urease and anti-elastase activities of Usnea longissima Ach.

2018

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Lichens are complex associations composed of mycobiont and one or more algae or cyanobacteria which are living in symbiosis. Lichens are thought to possess therapeutic effects on many illnesses in worldwide. This study was performed to investigate antioxidant, anti-elastase and anti-urease activities of Usnea longissima Ach lichen. U. longissima was extracted with ethanol and ethyl acetate solvents. The antioxidant activities of the extracts of U. longissima were determined with methods such as 1,1-diphenyl-2picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging activity, copper reducing antioxidant capacity (CUPRAC), total antioxidant capacity, determination of total phenolic content and total flavonoid contents. The binding action of the DPPH and ABTS radicals, CUPRAC activity increases with concentration of the extracts. Ethanol extracts exhibited higher anti-urease and anti-elastase activity. Highest inhibition was found as 49.86% for elastase and 18.38% for urease. Results of the present study suggest that U. longissima extracts can be an alternative to synthetic antioxidant, anti-elastase and anti-urease agents.

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“…The methanolic extracts of Usnea longissima showed powerful hepato-protective and antioxidant activity against several experimental animals [52]. Hepatotoxicity study was carried out, in which ethanolic extract of U. longissima at doses 200 and 400 mg/kg body weight) were compared with Silymarin (25 mg/kg body weight).…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Ethnobiology, Phytochemistry and Pharmacology of Usnea Longissima A Review

Sharma¹,

Bhat²

2019

IJSRBS

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Lichenized fungi or lichens are believed to be one of the most inconspicuous living forms on the earth. The traditional knowledge of numerous benefits which lichens possess has been transcended over the centuries within and among the humans. All the different growth forms of lichens have been used by man in one way or the other. These find their use as source of different medicines, food, fodder, dye and as ingredients in perfumery. They are pioneers in ecological succession and also serve as indicators of pollution. Usnea longissima is a fruticose form of lichen that has been used as a traditional medicine for centuries. Scientific studies have proved that the pharmacological properties of the species are due to presence of several important secondary metabolites. These secondary metabolites possess antioxidant, anticancer, antimicrobial activity and thus can be used for the control and treatment of several diseases. The present communication gives a review of the multifarious benefits associated with Usnea longissima along with the emphasis on its pharmacological properties.

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Hematological, antioxidant and protective performance of Usnea longissima on chemical induced hepatotoxicity in experimental animals

Cited by 3 publications

References 31 publications

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

Antioxidant, anti-urease and anti-elastase activities of Usnea longissima Ach.

Ethnobiology, Phytochemistry and Pharmacology of Usnea Longissima A Review

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