Toxicity of zinc oxide nanoparticles through oral route

Pasupuleti, Surekha; Alapati, Srinivas; Ganapathy, Selvam; Goparaju, A; Pully, Neelakanta Reddy; Prakhya, Balakrishna Murthy

doi:10.1177/0748233711420473

Cited by 104 publications

(82 citation statements)

References 22 publications

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“…In liver tissue, the hydropic degeneration around the central vein was prominent and the spotty necrosis of hepatocyte was also found in the female mice postexposure 2 weeks to the 80 nm and fine TiO 2 particles. Pasupuleti et al [28] showed that the Liver with nanozinc oxide at dose of 2000 mg/kg B.W. appears focal necrosis of liver.…”

Section: Hematology Findings Of Current Study Inmentioning

confidence: 99%

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Elsayed¹,

Al-Sherbini

Abd-Elhady

et al. 2014

ISRN Nanotechnology

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Iron deficiency anemia is a major global public health problem. Food fortification with iron (Fe) can be an effective strategy to control iron deficiency. An iron oxide nanoparticle (NP) is a new physical and chemical property form. These properties (small particle size, unique physical properties) make nanoiron a great scientific interest especially in the treatment of anemia. The study aimed to reduce anemia by nanoparticles (NPs). Forty-eight adult female Sprague-Dewily rats were divided into four groups (12 rats each). Group A represented a negative control. Other groups were fed standard diet iron free and three time of require zinc to reach anemic. Group B fed standard diet with ferrous sulfate until the improvement of the situation of anemia or for 8 weeks. Groups C and D were divided into three subgroups; each subgroup was fed a dose from magnetite or folate coated magnetite NPs. Results showed that symptoms of loss of appetite and severe lethargy demonstrate that magnetite and folate-coated magnetite nanoparticles have serious toxicological effects in vivo. Some doses from NPs improve blood picture during 2 weeks but change in histopathology examinations were occur in some groups within 2 weeks. Nanoparticles were considered the toxicological hazards especially the size of less than 54 nm.

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Section: Hematology Findings Of Current Study Inmentioning

confidence: 99%

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Elsayed¹,

Al-Sherbini

Abd-Elhady

et al. 2014

ISRN Nanotechnology

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show abstract

“…Several rodent feeding studies have demonstrated particle sizedependent effects on the intestinal uptake of ZnO nanoparticles, with a smaller particle size leading to a higher uptake. [40][41][42][43] One study reported that a single oral dose of ZnO nanoparticles caused hepatic injury, kidney toxicity, and lung damage. 44 Interestingly, one study showed that ZnO nanoparticles were not toxic when used in isolation, but that they become toxic when mixed with ascorbic acid.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Is nano safe in foods? Establishing the factors impacting the gastrointestinal fate and toxicity of organic and inorganic food-grade nanoparticles

2017

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Nanotechnology offers the food industry a number of new approaches for improving the quality, shelf life, safety, and healthiness of foods. Nevertheless, there is concern from consumers, regulatory agencies, and the food industry about potential adverse effects (toxicity) associated with the application of nanotechnology in foods. In particular, there is concern about the direct incorporation of engineered nanoparticles into foods, such as those used as delivery systems for colors, flavors, preservatives, nutrients, and nutraceuticals, or those used to modify the optical, rheological, or flow properties of foods or food packaging. This review article summarizes the application of both inorganic (silver, iron oxide, titanium dioxide, silicon dioxide, and zinc oxide) and organic (lipid, protein, and carbohydrate) nanoparticles in foods, highlights the most important nanoparticle characteristics that influence their behavior, discusses the importance of food matrix and gastrointestinal tract effects on nanoparticle properties, emphasizes potential toxicity mechanisms of different food-grade nanoparticles, and stresses important areas where research is still needed. The authors note that nanoparticles are already present in many natural and processed foods, and that new kinds of nanoparticles may be utilized as functional ingredients by the food industry in the future. Many of these nanoparticles are unlikely to have adverse affects on human health, but there is evidence that some of them could have harmful effects and that future studies are required.

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“…[8][9][10] Several studies have begun to investigate the toxicity of inorganic nanoparticles to intestinal epithelial cells both in vitro 9 and in vivo. [11][12][13][14] Based on the toxicity studies that have been conducted in different systems, it is apparent that toxicity depends upon many different properties of nanoparticles. Particle size influences toxicity, with nanoparticles showing greater toxicity than their larger counterparts.…”

Section: Introductionmentioning

confidence: 99%

Minimal Intestinal Epithelial Cell Toxicity in Response to Short- and Long-Term Food-Relevant Inorganic Nanoparticle Exposure

McCracken

Zane

Knight

et al. 2013

Chem. Res. Toxicol.

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Toxicity of commercial nanoparticles of titania, silica, and zinc oxides is being investigated in this in vitro study. Particles of these compositions are found in many food items, and thus this study is directed toward particle behavior in simulated digestion media and their interaction with intestinal epithelial cell line C2BBe1, a clone of Caco-2 cells, originally isolated from a human colon cancer. Even though the primary particle size of all three particles was below 50 nm, the particles appeared as aggregates in culture media with a negatively charged surface. In the presence of pepsin (pH 2), the charge on the titania became positive, and silica was almost neutral and aggregated extensively, whereas ZnO dissolved. For silica and titania, treatment with simulated intestinal digestive solution led to a strongly negatively charged surface and particle sizes approaching values similar to those in media. On the basis of infrared spectroscopy, we concluded that the surface of silica and titania was covered with bile salts/proteins after this treatment. Transmission electron microscopy indicated that the C2BBe1 cells internalized all three particles. Toxicity assays included investigation of necrosis, apoptosis, membrane damage, and mitochondrial activity. Titania and SiO2 particles suspended in media at loading levels of 10 μg/cm2 exhibited no toxicity. With ZnO at the same loading level, mild toxicity was observed based only on the LDH assay and decrease of mitochondrial activity and not necrosis or apoptosis. Titania particles exposed to the simulated digestion media exhibited mild toxicity based on decrease of mitochondrial activity, likely due to transport of toxic bile salts via adsorption on the particle surface.

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Toxicity of zinc oxide nanoparticles through oral route

Cited by 104 publications

References 22 publications

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Is nano safe in foods? Establishing the factors impacting the gastrointestinal fate and toxicity of organic and inorganic food-grade nanoparticles

Minimal Intestinal Epithelial Cell Toxicity in Response to Short- and Long-Term Food-Relevant Inorganic Nanoparticle Exposure

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