Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Abstract

Iron deficiency anemia is a major global public health problem. Food fortification with iron (Fe) can be an effective strategy to control iron deficiency. An iron oxide nanoparticle (NP) is a new physical and chemical property form. These properties (small particle size, unique physical properties) make nanoiron a great scientific interest especially in the treatment of anemia. The study aimed to reduce anemia by nanoparticles (NPs). Forty-eight adult female Sprague-Dewily rats were divided into four groups (12 rats each). Group A represented a negative control. Other groups were fed standard diet iron free and three time of require zinc to reach anemic. Group B fed standard diet with ferrous sulfate until the improvement of the situation of anemia or for 8 weeks. Groups C and D were divided into three subgroups; each subgroup was fed a dose from magnetite or folate coated magnetite NPs. Results showed that symptoms of loss of appetite and severe lethargy demonstrate that magnetite and folate-coated magnetite nanoparticles have serious toxicological effects in vivo. Some doses from NPs improve blood picture during 2 weeks but change in histopathology examinations were occur in some groups within 2 weeks. Nanoparticles were considered the toxicological hazards especially the size of less than 54 nm.

Preparation and Evaluation of Iron Oxide Nanoparticles for Treatment of Iron Deficiency Anemia

“…1C) were similar in shape but larger in size with aggregations. Similar results have been previously reported [15][16][17]. The observed aggregations of the coated iron oxide nanoparticles might be due to the incomplete coating of individual particles by folic acid or chitosan [20].…”

“…Similar results have been previously reported [15]. Data are given in mean±SD, dl= deciliter, SD= standard deviation, n= number of rats.…”

“…After coating with folic acid and chitosan, the mean particle size increased to 220.2±12 nm and 295.3±19 nm, respectively. The obtained particle sizes of the coated iron oxide nanoparticles are larger than that reported previously for either folic acid-coated [15] or chitosan-coated iron oxide nanoparticles [17]. The particle size distribution of all samples ( fig.…”

“…Recent researches on the gastrointestinal absorption of nanoparticles focus on enhancing the absorption of drugs, vaccines and nutrients that either are degraded by the digestive process or poorly absorbed [13,14]. Several iron nanoparticles formulations were prepared to treat IDA with great efficiency and low side effects instead of the frequently used iron salt [15,16]. The objective of this study was to prepare iron oxide nanoparticles and evaluate their potential as an iron supplement in the treatment of IDA compared to a commercial iron preparation.…”

Efficiency of Novel Antimicrobial Coating Based on Iron Nanoparticles for Dairy Products’ Packaging

“…The safety of the application of ferrous iron and especially nano-compounds of ZVI, in packaging materials, is also the subject of many discussions [31][32][33]. No harmful effects of iron on human organisms were found, even nano-iron supplements are used to thread anemia [34][35][36]. Their beneficial effect on iron deficiency anemia occurs at doses from 3 mg to 6 mg per kilogram of body weight per day.…”