Toxicity of triorganotin compounds to the brine shrimp, Artemia salina

Abstract

The 14 triorganotin compounds that were screened against the brine shrimp, Artemia salina, were least effective against the first nauplii stage (24 h). This was attributed to the presence of a yolk membrane which reduced the contact between the triorganotin compounds and the organism. The data indicated that the species responsible for the toxicity is primarily the hydrated triorganotin cation. However, the anion X group may also play a minor role in the toxicity of these compounds. The observed order of activity for the triorganotins does not parallel their hydrophobicities, indicating that other factors must be involved in the toxicity mechanism.

A toxicidade em ambientes aquáticos: discussão e métodos de avaliação

“…60,62 O crustáceo de água salgada Artemia salina também é uma espécie bastante utilizada em testes de toxicidade. [63][64][65] A utilização dessa espécie é interessante porque seus ovos resistem à secagem e estocagem por longos períodos de tempo. Quando os ovos secos são colocados em água do mar e incubados a aproximadamente 23 o C, eles eclodem dentro de 1 ou 2 dias e após isso os organismos já estão prontos para serem utilizados nos testes de ecotoxicidade.…”

Structural elucidation and evaluation of toxicity and antitumor activity of cardiac glycosides isolated fromLeptadenia pyrotechnica

“…The second method plotted dosage against percentage mortality and the dosage at 50% mortality was obtained by intersection. This method was used to estimate the standard error (Nguyen et al, 1998;Yang et al, 2001). …”