Structural elucidation and evaluation of toxicity and antitumor activity of cardiac glycosides isolated from<i>Leptadenia pyrotechnica</i>

Moustafa, Amal M. Youssef; Khodair, Ahmed I.; Saleh, Mahmoud A.

doi:10.1080/13880200902902505

Cited by 13 publications

(9 citation statements)

References 38 publications

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“…Exciting recent findings have suggested additional signaling modes of action of Na + /K + -ATPase that implicate the cardiac glycosides in the regulation of several important cellular processes and highlight new therapeutic roles for these compounds in various diseases. During the past three decades, it has been suggested that cardiac glycosides inhibit cell proliferation and possess valuable cytotoxic activity against different tumour cell lines, usually by inducting apoptosis [63,[130][131][132][133][134][135][136]. Interferences between GCs and the corresponding transporters may be responsible for the toxicity of the GCs.…”

Section: Cytotoxicity Of Cardiac Glycosides and Mechanisms Of Its Actionmentioning

confidence: 99%

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Babula¹,

Masařík²,

Adam³

et al. 2013

ACAMC

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The cardiac glycosides are a group of compounds isolated from plants and some animals. They have been used in therapy for heart failure for many years. The cytotoxic effect of many cardiac glycosides has been demonstrated, but the mechanism of action is very complicated and complex, and Na+/K+-ATPase surely plays a crucial role in it. On the other hand, Na+/K+-ATPase is regulated by many endogenous factors, such as hormones or FXYD proteins, whose role in regulating the cell cycle has been studied intensively. This review focuses on the role of Na+/K+-ATPase in regulating the cell growth, the cell cycle and the cell proliferation and on the involvement of cardiac glycosides in regulating Na+/K+-ATPase. The cytotoxic effect of cardiac glycosides is discussed with respect to the apoptotic mechanisms possibly induced by these compounds. Novel strategies in cancer therapy based on cardiac glycosides are discussed as are possibilities for counteracting multidrug resistance by using cardiac glycosides. The aim of this review is to present cardiac glycosides not only as pharmaceuticals used in the management of heart failure, but also as potent cytotoxic agents with potential uses in cancer treatment.

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Section: Cytotoxicity Of Cardiac Glycosides and Mechanisms Of Its Actionmentioning

confidence: 99%

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Babula¹,

Masařík²,

Adam³

et al. 2013

ACAMC

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“…4 – 6 Previous phytochemical investigations reported the presence of flavonoids5,7,8 terpenoids1–10 polyoxypregnane esters,4,11 pregnane glycosides,12,13 cardiac glycosides14 and alkaloids15 in these species. The medicinal use of plants containing cardiac glycosides was recorded as early as 1500 years ago.…”

Section: Introductionmentioning

confidence: 98%

Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest

Pan

Harinantenaina

Brodie

et al. 2011

Bioorganic & Medicinal Chemistry

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Investigation of the endemic Madagascar plant Leptadenia madagascariensis Decne. (Apocynaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the four new cardenolides 1-4. The structure elucidations of these compounds were based on analyses of their 1D and 2D NMR spectra and mass spectrometric data. The cardenolides were strongly antiproliferative to the A2780 ovarian cancer cell line, with IC 50 values of 0.18, 0.21, 0.17 and 0.29 μM line, and to the H460 human lung cancer cell line, with IC 50 values of 0.16, 0.68, 0.37 and 0.48 μM respectively.

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“… A typical HPLC chromatograph showing the standard mixture of phenolic compounds, i.e., [ 1 ] caffeic acid, [ 2 ] resorcinol, [ 6 ] vanillic acid, [ 7 ] p -coumaric acid, [ 9 ] ferulic acid, [ 10 ] vanillin, [ 11 ] veratric acid, [ 4 ] myristicin, [ 5 ] coumarin, and cinnamic acid. …”

Section: Figurementioning

confidence: 99%

“…L. pyrotechnica is a characteristic desert plant [ 1 ] commonly known as Khimp, Kip, or Kheep [ 2 ]. It is an erect ascending, leafless, sappy, evergreen shrub which grows from 1.5 m to 3 m high.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Determination of Phenolic Compounds in Leptadenia pyrotechnica (Forssk.) Decne. by Using High-Performance Liquid Chromatography (HPLC-DAD-UV)

Preet

Gupta

2018

Advances in Pharmacological Sciences

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During the present study, an endeavor has been made to produce a simple, rapid, and simultaneous method for determination of phenolic compounds by using high-performance liquid chromatography in aerial parts of Leptadenia pyrotechnica (Forssk.) Decne. collected from the Indian Thar Desert. The optimized process was used for the quantification of ten phenolic compounds. The chromatographic separation was accomplished on an Atlantis T3 column at 25°C with isocratic elution. A mixture of acetonitrile and water was used as the mobile phase at a flow rate of 0.8 mL/min. The linear regression examination data for the calibration plots displayed a good linear relationship with r2 > 0.999 in the concentration range of 2–20 µL. In the methanolic extracts of the whole plant of L. pyrotechnica, the content of caffeic acid (3.3%) was reported to be the highest concentration.

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Structural elucidation and evaluation of toxicity and antitumor activity of cardiac glycosides isolated fromLeptadenia pyrotechnica

Cited by 13 publications

References 38 publications

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest

Simultaneous Determination of Phenolic Compounds in Leptadenia pyrotechnica (Forssk.) Decne. by Using High-Performance Liquid Chromatography (HPLC-DAD-UV)

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