Toxicity-attenuated mesoporous silica Schiff-base bonded anticancer drug complexes for chemotherapy of drug resistant cancer

Cai, Ling; Zhu, Ping; Huan, Fei; Wang, Jun; Zhou, Liuzhu; Jiang, Huijun; Ji, Minghui; Chen, Jin

doi:10.1016/j.colsurfb.2021.111839

Cited by 16 publications

(7 citation statements)

References 46 publications

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“…The synthesis of polymers Schiff base improved the physicochemical features of the end products, such as thermo‐stability, and synthetic variety. Schiff bases revealed varied biological activities, including antifungal, antiproliferative, antibacterial, anti‐inflammatory, antimalarial, antiviral, antitumor, anti‐COVID‐19, and antipyretic properties 15‐20 . The biological activities of various polymers containing Schiff base moiety were recorded, for example Chitosan, 21‐23 cellulose, 24,25 and acrylic acid derivatives 26,27 .…”

Section: Introductionmentioning

confidence: 99%

“…Schiff bases revealed varied biological activities, including antifungal, antiproliferative, antibacterial, anti-inflammatory, antimalarial, antiviral, antitumor, anti-COVID-19, and antipyretic properties. [15][16][17][18][19][20] The biological activities of various polymers containing Schiff base moiety were recorded, for example Chitosan, [21][22][23] cellulose, 24,25 and acrylic acid derivatives. 26,27 Tetronics are amphiphilic, synthetic polyethers composed of polyethylene oxide and polypropylene oxide connected to ethylenediamine central.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, antimicrobial and anticancer activities of Tetronic 1107 Schiff bases

Alasmary

Kenawy

El‐Deeb

et al. 2022

Polymers for Advanced Techs

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As a result of the serious issues connected to the bacterial infections, there is an imperious need to improve strong and ecofriendly antimicrobial polymers to overcome the limitations of conventional antimicrobial agents. In this trend, poloxamines (Tetronics) which are X‐shaped poly(ethylene oxide)–poly(propylene oxide) diblocks linked to a focal ethylenediamine group; were successfully modified to produce Tetronic Schiff base for enhancing the biological activities of Tetronic 1107. Modification of tetronic 1107 (T1107) was proceeded throughout chloroacetylation of T1107 followed by amination using p‐phenylenediamine then the latter was treated with different aldehydes to yield Tetronic Schiff bases. Characterization of Tetronic Schiff bases was carried out by 1H‐NMR, Fourier‐transform infrared spectroscopy, X‐ray diffraction, elemental analysis and thermogravimetric analysis (TGA) analyses. The antimicrobial activities of four tested compounds coded (EK1, EK2, EK3, and EK4) were quantified using Microtiter‐assay methods. The obtained data revealed potential antimicrobial activities for tested compounds against all tested microbes with priority against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. Sample coded EK4 exhibited the most effective treatment against P. aeruginosa, Candida albicans, S. aureus and E. Coli with minimal inhibitory concentration values of 6, 16, 12.5, and 1.5 μM, respectively. Furthermore, the safety results confirmed that EK4 and EK1 were the safest treatment with IC50 values of 76.01 and 62.67 μM, respectively. In addition, all tested compounds showed significant anticancer effects against MDA‐MB‐231cell line, while EK3 was effective treatment against A549 cell line with IC50 values of 39.63 μM. Meanwhile, both EK2 and EK4 showed the highest selectivity index (SI) values against MDA‐MB‐231 cell line with values 2.5 and 3.07, respectively. Interestingly, EK4 showed the maximum SI values on A549 and Hep‐G2 cell lines with values 1.62 and 1.52, respectively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, antimicrobial and anticancer activities of Tetronic 1107 Schiff bases

Alasmary

Kenawy

El‐Deeb

et al. 2022

Polymers for Advanced Techs

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“…MSNs have been used as drug carriers for short-term multiple administration to treat cancer in mouse models. , However, the toxicity of MSNs has been ignored in these studies. We performed biodistribution research and subacute toxicity study of S-MSN and R-MSN in C57/BL6 mice.…”

Section: Resultsmentioning

confidence: 99%

Shape and Shear Stress Impact on the Toxicity of Mesoporous Silica Nanoparticles: In Vitro and In Vivo Evidence

et al. 2023

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Mesoporous silica nanoparticles (MSNs) are widely used in the biomedical field because of their unique and excellent properties. However, the potential toxicity of different shaped MSNs via injection has not been fully studied. This study aims to systematically explore the impact of shape and shear stress on the toxicity of MSNs after injection. An in vitro blood flow model was developed to investigate the cytotoxicity and the underlying mechanisms of spherical MSNs (S-MSN) and rodlike MSNs (R-MSN) in human umbilical vein endothelial cells (HUVECs). The results suggested that the interactions between MSNs and HUVECs under the physiological flow conditions were significantly different from that under static conditions. Whether under static or flow conditions, R-MSN showed better cellular uptake and less oxidative damage than S-MSN. The main mechanism of cytotoxicity induced by R-MSN was due to shear stress-dependent mechanical damage of the cell membrane, while the toxicity of S-MSN was attributed to mechanical damage and oxidative damage. The addition of fetal bovine serum (FBS) alleviated the toxicity of S-MSN by reducing cellular uptake and oxidative stress under static and flow conditions. Moreover, the in vivo results showed that both S-MSN and R-MSN caused cardiovascular toxicity in zebrafish and mouse models due to the high shear stress, especially in the heart. S-MSN led to severe oxidative damage at the accumulation site, such as liver, spleen, and lung in mice, while R-MSN did not cause significant oxidative stress. The results of in vitro blood flow and in vivo models indicated that particle shape and shear stress are crucial to the biosafety of MSNs, providing new evidence for the toxicity mechanisms of the injected MSNs.

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“…By comparison, it was found that the EE and DL of MSNs-HA-11C12 decreased slightly in that the loss of DOX occurred during HA and 11C12 modified MSNs-NH 2 . Although MSNs have made great progress as nanocarriers, their low DL, which is generally less than 20%, 6,34,37,38 has limited their applications. This dual targeting MSNs based on HA and nanobody 11C12 achieved a relatively high drug loading efficiency up to 26.77%, which reduces the accumulation of foreign materials in vivo and enhances the safety of cancer treatment.…”

Section: Dox Loading and In Vitro Dox Release Kineticsmentioning

confidence: 99%

Dual CEA/CD44 targeting to colorectal cancer cells using nanobody-conjugated hyaluronic acid-modified mesoporous silica nanoparticles with pH- and redox-sensitivity

et al. 2022

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Toxicity-attenuated mesoporous silica Schiff-base bonded anticancer drug complexes for chemotherapy of drug resistant cancer

Cited by 16 publications

References 46 publications

Synthesis, antimicrobial and anticancer activities of Tetronic 1107 Schiff bases

Synthesis, antimicrobial and anticancer activities of Tetronic 1107 Schiff bases

Shape and Shear Stress Impact on the Toxicity of Mesoporous Silica Nanoparticles: In Vitro and In Vivo Evidence

Dual CEA/CD44 targeting to colorectal cancer cells using nanobody-conjugated hyaluronic acid-modified mesoporous silica nanoparticles with pH- and redox-sensitivity

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