Dual CEA/CD44 targeting to colorectal cancer cells using nanobody-conjugated hyaluronic acid-modified mesoporous silica nanoparticles with pH- and redox-sensitivity

Fan, Xiying; Wang, Tingting; Han, Min; Gu, Yi; Sun, Guochuan; Peng, Xinying; Shou, Qinghui; Song, Haipeng; Liu, Wenshuai; Nian, Rui

doi:10.1039/d2ma00082b

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…Several studies have demonstrated improved delivery when a nanoparticle is actively targeted to CEA in colorectal cancer cells using site specific reagents such as antibodies, antibodyfragments, aptamers, peptides and nanobodies. [35][36][37][38][39] To date, the anti-CEA antibody has shown the most promising targeting bioreceptor in colorectal murine models but translation to clinical application was complicated by the immunogenicity and the clearance from bloodstream, both owing to binding of Fc receptor-containing entities to the antibody Fc region. 40 In addition, antibody size (∼150 kDa) makes cell penetration difficult.…”

Section: Discussionmentioning

confidence: 99%

Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle

Khaled,

Khot,

Aiyappa-Maudsley

et al. 2024

Nanoscale

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Section: Discussionmentioning

confidence: 99%

Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle

Khaled,

Khot,

Aiyappa-Maudsley

et al. 2024

Nanoscale

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Recent advances and applications of peptide–agent conjugates for targeting tumor cells

Alamdari-Palangi

Jaberi

Shahverdi

et al. 2023

J Cancer Res Clin Oncol

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Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges

Narayana,

Gowda,

Hani

et al. 2024

J Nanobiotechnol

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Colorectal cancer, the third most prevalent cancer globally, contributes significantly to mortality rates, with over 1.9 million reported cases and nearly 935,000 fatalities annually. Surgical resection is a primary approach for localized colorectal tumors, with adjunct therapies like chemotherapy, radiotherapy, and targeted/immunotherapy considered depending on the tumor stage. However, despite preferences for targeted and immunotherapy post-surgery, chemotherapy remains commonly chosen due to its lower cost and high cancer-killing efficiency. Yet, chemotherapy faces issues such as tumor resistance and severe side effects. Nanotechnology has emerged in cancer therapy by alleviating the drawbacks of current treatment approaches. In the past few decades, inorganic nanoparticles have shown promise in combating colorectal cancer, offering advantages over conventional chemotherapy. Compared to organic nanoparticles, inorganic nanoparticles exhibit properties like photosensitivity, conductivity, magnetic allure, and thermal proficiency, allowing them to function as both drug carriers and therapeutic agents. Derived primarily from carbon, silica, metals, and metal oxides, they offer superior drug-loading capacity, heightened quantum yield, and participation in advanced photothermal and photodynamic therapies. This review provides a brief overview of the pathophysiology of colorectal cancer and the pivotal role of inorganic nanoparticles in photothermal therapy photodynamic therapy, and drug delivery. Additionally, it discusses numerous inorganic nanoparticles in colorectal cancer therapy based on recent literature. Graphical abstract

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Dual CEA/CD44 targeting to colorectal cancer cells using nanobody-conjugated hyaluronic acid-modified mesoporous silica nanoparticles with pH- and redox-sensitivity

Abstract: Colorectal cancer (CRC) is the second leading cause of cancer death among all malignancies. Drug delivery targeting tumor surface receptors improves therapeutic effects and lowers side-effects since it can increase...

Cited by 4 publications

References 41 publications

Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle

Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle

Recent advances and applications of peptide–agent conjugates for targeting tumor cells

Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges

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