Recent advances and applications of peptide–agent conjugates for targeting tumor cells

Alamdari-Palangi, Vahab; Jaberi, Khojaste Rahimi; Shahverdi, Mahshid; Naeimzadeh, Yasaman; Tajbakhsh, Amir; Khajeh, Sahar; Razban, Vahid; Fallahi, Jafar

doi:10.1007/s00432-023-05144-9

J Cancer Res Clin Oncol

2023

DOI: 10.1007/s00432-023-05144-9

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Recent advances and applications of peptide–agent conjugates for targeting tumor cells

Vahab Alamdari-Palangi

Khojaste Rahimi Jaberi

Mahshid Shahverdi

et al.

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2024

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Cited by 3 publications

References 250 publications

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Screening and Exploring the Application of the Multifunctional Antioxidant Peptides MSWLC and TSWLC

Yu,

Wang,

Wang

et al. 2024

Adv Healthcare Materials

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In this study, an antioxidant pentapeptide library is created based on antioxidant characteristics. The peptides are then purified and separated using liquid chromatography/mass spectrometry (LC/MS) and time‐of‐flight mass spectrometry (TOF). Chemical evaluations identify four peptides with excellent antioxidant activity. The four peptides undergo biocompatibility testing with L‐929, NIH 3T3, and Hep‐G2 cells. A model of hydrogen peroxide‐induced cellular damage in G2 cells shows the peptides' protective and reparative effects against oxidative damage. Two peptides, MSWLC and TSWLC, which perform best overall, are chosen for further analysis. To explore the peptides' potential multifunctionality, acute liver inflammation, keratitis, and aging models are established in mice. MSWLC and TSWLC demonstrate anti‐inflammatory and anti‐aging properties. An antioxidant emulsion prepared by emulsification is found to be non‐irritant in a mouse skin irritation test. In a mouse model exposed to ultraviolet radiation, the sunscreen exhibits excellent UV protection and antioxidant effects. These peptides possess potent antioxidant properties and multifunctionality, indicating broad application potential.

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Screening and Exploring the Application of the Multifunctional Antioxidant Peptides MSWLC and TSWLC

Yu,

Wang,

Wang

et al. 2024

Adv Healthcare Materials

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Design and synthesis of TH19P01-Camptothecin based hybrid peptides inducing effective anticancer responses on sortilin positive cancer cells

Li,

Fang,

Wang

et al. 2024

Bioorganic & Medicinal Chemistry

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Biological Activity of Natural and Synthetic Peptides as Anticancer Agents

Bauso,

La Fauci,

Munaò

et al. 2024

IJMS

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Cancer is one of the leading causes of morbidity and death worldwide, making it a serious global health concern. Chemotherapy, radiotherapy, and surgical treatment are the most used conventional therapeutic approaches, although they show several side effects that limit their effectiveness. For these reasons, the discovery of new effective alternative therapies still represents an enormous challenge for the treatment of tumour diseases. Recently, anticancer peptides (ACPs) have gained attention for cancer diagnosis and treatment. ACPs are small bioactive molecules which selectively induce cancer cell death through a variety of mechanisms such as apoptosis, membrane disruption, DNA damage, immunomodulation, as well as inhibition of angiogenesis, cell survival, and proliferation pathways. ACPs can also be employed for the targeted delivery of drugs into cancer cells. With over 1000 clinical trials using ACPs, their potential for application in cancer therapy seems promising. Peptides can also be utilized in conjunction with imaging agents and molecular imaging methods, such as MRI, PET, CT, and NIR, improving the detection and the classification of cancer, and monitoring the treatment response. In this review we will provide an overview of the biological activity of some natural and synthetic peptides for the treatment of the most common and malignant tumours affecting people around the world.

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Recent advances and applications of peptide–agent conjugates for targeting tumor cells

Cited by 3 publications

References 250 publications

Screening and Exploring the Application of the Multifunctional Antioxidant Peptides MSWLC and TSWLC

Screening and Exploring the Application of the Multifunctional Antioxidant Peptides MSWLC and TSWLC

Design and synthesis of TH19P01-Camptothecin based hybrid peptides inducing effective anticancer responses on sortilin positive cancer cells

Biological Activity of Natural and Synthetic Peptides as Anticancer Agents

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